Nonlocality and entanglement in measured critical quantum Ising chains

We study the effect of measurements, performed with a finite density in space, on the ground state of the one-dimensional transverse-field Ising model (TFIM) at criticality. Local degrees of freedom in critical states exhibit long-range entanglement and, as a result, local measurements can have highly nonlocal effects. Our analytical investigation of correlations and entanglement in the ensemble of measured states is based on properties of the Ising conformal field theory (CFT), where measurements appear as (1+0)-dimensional defects in the (1+1)-dimensional Euclidean spacetime. So that we can verify our predictions using large-scale free-fermion numerics, we restrict ourselves to parity-symmetric measurements. To describe their averaged effect analytically we use a replica approach, and we show that the defect arising in the replica theory is an irrelevant perturbation to the Ising CFT. Strikingly, the asymptotic scaling of averaged correlations and entanglement entropy are therefore unchanged relative to the ground state. In contrast, the defect generated by postselecting on the most likely measurement outcomes is exactly marginal. We then find that the exponent governing post-measurement order parameter correlations, as well as the ''effective central charge'' governing the scaling of entanglement entropy, vary continuously with the density of measurements in space. Our work establishes new connections between the effects of measurements on many-body quantum states and of physical defects on low-energy equilibrium properties.Comment: 11+14 pages, 5+4 figure

A Rare Case of Situs Inversus with Mesocardia

A ten year old male child having congenital heart disease admitted with recurrent history of respiratory infection. ECHO cardioraphy showed Mesocardia, congenitally corrected TGA, bidirectional VSD and severe pulmonary valve stenosis.On sonographic evaluation showed intra-abdominal mirror imaging of all the solid organs and vessels which was suggestive of a rare presentation of Sinus inverses with Mesocardia. Corrective surgery as pulmonary valve balloon dilation or valvuloplasty and vestricular septal repair has to be done to the child for better morbidity and reducing the mortality risk. This anomaly complicates the diagnosis and management of acute abdominal conditions like appendicitis, diverticulitis and biliary coli

COST OF THERAPY INCURRED FOR TUBERCULOSIS PATIENTS RECEIVING DIRECTLY OBSERVED THERAPY (DOT)

Objective: To estimate the cost of therapy of tuberculosis patients registered under DOTS program in the treatment of tuberculosis.Methods: A prospective observational study was conducted over a period of nine months in the Pulmonary Department of Bharati hospital and Research centre, Pune. 97 patients registered under RNTCP between August 2014 and April 2015, were interviewed at two time points: one at the time of first hospital visit and second on the completion of treatment. During the interview, information relating to various costs such as direct (out of pocket) and indirect cost was collected.Results: The mean total cost for Pulmonary tuberculosis treatment was found to be/5474.7 ($85.4), Extra pulmonary was/10574.8 ($164.9) and Pulmonary and Extra pulmonary was/14638.5 ($228.3) respectively. Out of total cost the cost incurred by the patients for the hospital stay and diagnosis (i.e. tuberculosis detection) has the maximum expenditure cost which was 90.4 % for pulmonary tuberculosis, 77.2% extra pulmonary and 72.5% pulmonary and extra pulmonary. About 39.2 % of patients and their care takers lost work days. 52.0% pulmonary patients, 68.4% extra-pulmonary and 66.7 % pulmonary and extra-pulmonary patients had decreased earning ability due to illness. Conclusion: The maximum cost is incurred for diagnosis and hospital stay in tuberculosis patients. Though DOTS strategy can help to reduce cost, achieve effective cure and save life of TB patients, still patients need to spend for other investigations and other drugs.Â

Extrapontine myelinolysis presenting as acute parkinsonism

BACKGROUND: Extrapontine myelinolysis presenting with extra pyramidal features suggestive of parkinsonism may be a challenging clinical syndrome. Clinicians should maintain their vigilance while correcting electrolyte imbalances, especially with associated co-morbidity. CASE PRESENTATION: A 41-year-old woman presented with acute parkinsonism like features while on a holiday. This followed slow correction of hyponatraemia after repeated vomiting. MRI changes were suggestive of Extrapontine myelinolysis(EPM). This case is at variance with four previous cases reported in the medical literature in that the patient made a full clinical recovery and the MR changes resolved with symptomatic support alone. CONCLUSION: Extrapontine myelinolysis could make a complete recovery with symptomatic support alone. During hyponatraemia correction, rapid osmotic shifts of fluid that cause hypernatremia, causes myelinolysis rather than absolute serum sodium level. Even gradual correction of hyponatraemia can produce myelinolysis, especially with pre-existing malnourishment, alcoholism, drug misuse, Addison's disease and immuno-suppression. Pallidial sparing is typical of EPM in MRI scans

Transient parkinsonism in isolated extrapontine myelinolysis

Extrapontine myelinolysis (EPM) is a rare cause of parkinsonism. In this case report, we describe a 63-year-old woman with parkinsonism due to EPM after correction of hyponatremia. During a 4-year follow-up, both the clinical features of parkinsonism and the changes on magnetic resonance imaging resolved. Parkinsonism due to EPM should be recognized as it has a good prognosis

EFFECT OF DATA QUALITY ON WATER BODY SEGMENTATION WITH DEEPLABV3+ ALGORITHM

Training Deep Learning (DL) algorithms for segmenting features require hundreds to thousands of input data and corresponding labels. Generating thousands of input images and labels requires considerable resources and time. Hence, it is common practice to use opensource imagery data and labels available online. Most of these open-source data have little or no metadata describing their quality or suitability making it problematic for training or evaluating DL models. This study evaluated the effect of data quality on training DeepLabV3+, using Sentinel 2 A/B RGB images and labels obtained from Kaggle. We generated subsets of 256 × 256 pixels, and 10% of these images (802) were set aside for testing. First, we trained and validated the DeepLabV3+ model with the remaining images. Second, we removed images with incorrect labels and trained another DeepLabV3+ network. Finally, we trained the third DeepLabV3+ network after removing images with turbid water or with floating vegetation. All three trained models were evaluated with test images and then we calculated accuracy metrics. As the quality of the input images improved, accuracy of the predicted masks generated from the first model increased from 92.8% to 94.3% in the second model. The third model’s accuracy was 96.4%, demonstrating the network’s ability to better learn and predict water bodies when the input data had fewer class variations. Based on the results we recommend assessing the quality of open-source data for incorrect labels and variations in the target class prior to training DeepLabV3+ or any other DL network

Comparative Genome-Wide Screening Identifies a Conserved Doxorubicin Repair Network That Is Diploid Specific in Saccharomyces cerevisiae

The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB) damage. In order to identify conserved genes that mediate DOX resistance, we screened the Saccharomyces cerevisiae diploid deletion collection and identified 376 deletion strains in which exposure to DOX was lethal or severely reduced growth fitness. This diploid screen identified 5-fold more DOX resistance genes than a comparable screen using the isogenic haploid derivative. Since DSB damage is repaired primarily by homologous recombination in yeast, and haploid cells lack an available DNA homolog in G1 and early S phase, this suggests that our diploid screen may have detected the loss of repair functions in G1 or early S phase prior to complete DNA replication. To test this, we compared the relative DOX sensitivity of 30 diploid deletion mutants identified under our screening conditions to their isogenic haploid counterpart, most of which (n = 26) were not detected in the haploid screen. For six mutants (bem1Δ, ctf4Δ, ctk1Δ, hfi1Δ,nup133Δ, tho2Δ) DOX-induced lethality was absent or greatly reduced in the haploid as compared to the isogenic diploid derivative. Moreover, unlike WT, all six diploid mutants displayed severe G1/S phase cell cycle progression defects when exposed to DOX and some were significantly enhanced (ctk1Δ and hfi1Δ) or deficient (tho2Δ) for recombination. Using these and other “THO2-like” hypo-recombinogenic, diploid-specific DOX sensitive mutants (mft1Δ, thp1Δ, thp2Δ) we utilized known genetic/proteomic interactions to construct an interactive functional genomic network which predicted additional DOX resistance genes not detected in the primary screen. Most (76%) of the DOX resistance genes detected in this diploid yeast screen are evolutionarily conserved suggesting the human orthologs are candidates for mediating DOX resistance by impacting on checkpoint and recombination functions in G1 and/or early S phases

Discovering New Strong Gravitational Lenses in the DESI Legacy Imaging Surveys

We have conducted a search for new strong gravitational lensing systems in the Dark Energy Spectroscopic Instrument Legacy Imaging Surveys’ Data Release 8. We use deep residual neural networks, building on previous work presented in Huang et al. (2020). These surveys together cover approximately one third of the sky visible from the northern hemisphere, reaching a z-band AB magnitude of ∼ 22.5. We compile a training sample that consists of known lensing systems as well as non-lenses in the Legacy Surveys and the Dark Energy Survey. After applying our trained neural networks to the survey data, we visually inspect and rank images with probabilities above a threshold. Here we present 1210 new strong lens candidates

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-I mediated interferon-β production. Furthermore, the screen identified a metabolic pathway that synthesizes the inositol pyrophosphate 1-IP7 as a previously unrecognized positive regulator of interferon production. Detailed genetic and biochemical experiments demonstrated that the kinase activities of IPPK, PPIP5K1 and PPIP5K2 (which convert IP5 to1-IP7) were critical for both interferon induction, and the control of cellular infection by Sendai and influenza A viruses. Conversely, ectopically expressed inositol pyrophosphate-hydrolases DIPPs attenuated interferon transcription. Mechanistic experiments in intact cells revealed that the expression of IPPK, PPIP5K1 and PPIP5K2 was needed for the phosphorylation and activation of IRF3, a transcription factor for interferon. The addition of purified individual inositol pyrophosphates to a cell free reconstituted RIG-I signaling assay further identified 1-IP7 as an essential component required for IRF3 activation. The inositol pyrophosphate may act by β-phosphoryl transfer, since its action was not recapitulated by a synthetic phosphonoacetate analogue of 1-IP7. This study thus identified several novel regulators of RIG-I, and a new role for inositol pyrophosphates in augmenting innate immune responses to viral infection that may have therapeutic applications