The Philosophy of the Face and 20th Century Literature and Art

This dissertation explores the importance of the human face in modern literature, philosophy, and art. Meaning is a physiognomy, wrote Wittgenstein--quite literally, if somewhat cryptically--in the Philosophical Investigations. My project takes this remark seriously and begins, in chapters one and two, by reading Wittgenstein\u27s discussion of aspect-seeing alongside recent work in cognitive science and the philosophy of mind in order to explain how we perceive mentality in the appearance of a human face. I then trace the surprising ways in which our ability to understand facial expressions informs not only the way we understand language, but also other minds and the concept of personhood itself. Chapters three and four extend these findings into an analysis of visual portraiture, focusing on the paintings of Francis Bacon. Regarding the sense of injury often associated with Bacon\u27s violently distorted likenesses, I ask why such magical feelings arise at all with respect to images of human faces. Reading Wittgenstein along with Gombrich and Wollheim, I find that the mind naturally responds to images of faces as expressive of mentality: we not only see faces in images but also to an extent see the images as persons. My final chapter looks into the ethics of physiognomy, asking what difference it makes whether we see the mind as a private substance or, as John Ashbery has suggested, a visible core. This chapter reads two narratives about faces that dramatize the solipsistic consequences of a Cartesian commitment to mental privacy: that of the faceless woman in Rilke\u27s Notebooks of Malte Laurids Brigge and the Magistrate\u27s dreams about the tortured woman in Coetzee\u27s Waiting for the Barbarians . I next consider Levinas\u27 ethics of the face, an ambivalent critique of Husserlian phenomenology that tries, but ultimately fails, to escape this Cartesian predicament. In the end, the convergence of ethics and physiognomy may explain the face\u27s importance to the modern imagination: perhaps, as Wittgenstein\u27s writings suggest, faces grip us so because they call upon the same powers of pattern recognition that enable us to grasp the reality of other minds and moral values as well

Superluminal Caustics of Close, Rapidly-Rotating Binary Microlenses

The two outer triangular caustics (regions of infinite magnification) of a close binary microlens move much faster than the components of the binary themselves, and can even exceed the speed of light. When $\epsilon > 1$, where $\epsilon c$ is the caustic speed, the usual formalism for calculating the lens magnification breaks down. We develop a new formalism that makes use of the gravitational analog of the Li\'enard-Wiechert potential. We find that as the binary speeds up, the caustics undergo several related changes: First, their position in space drifts. Second, they rotate about their own axes so that they no longer have a cusp facing the binary center of mass. Third, they grow larger and dramatically so for $\epsilon >> 1$. Fourth, they grow weaker roughly in proportion to their increasing size. Superluminal caustic-crossing events are probably not uncommon, but they are difficult to observe.Comment: 12 pages, 7 ps figures, submitted to Ap

A key to room-temperature ferromagnetism in Fe-doped ZnO: Cu

Successful synthesis of room-temperature ferromagnetic semiconductors, Zn$_{1-x}$Fe$_{x}$O, is reported. The essential ingredient in achieving room-temperature ferromagnetism in bulk Zn$_{1-x}$Fe$_{x}$O was found to be additional Cu doping. A transition temperature as high as 550 K was obtained in Zn$_{0.94}$Fe$_{0.05}$Cu$_{0.01}$O; the saturation magnetization at room temperature reached a value of $0.75 \mu_{\rm B}$ per Fe. Large magnetoresistance was also observed below $100$K.Comment: 11 pages, 4 figures; to appear in Appl. Phys. Let

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.

BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult to achieve in a predictable manner using targeted systems.ResultsHere, we report that persistent epigenetic memory required both a DNA methyltransferase (DNMT3A-dCas9) and a histone methyltransferase (Ezh2-dCas9 or KRAB-dCas9). We demonstrate that the histone methyltransferase requirement can be locus specific. Co-targeting Ezh2-dCas9, but not KRAB-dCas9, with DNMT3A-dCas9 and DNMT3L induced long-term HER2 repression over at least 50 days (approximately 57 cell divisions) and triggered an epigenetic switch to a heterochromatic environment. An increase in H3K27 trimethylation and DNA methylation was stably maintained and accompanied by a sustained loss of H3K27 acetylation. Interestingly, substitution of Ezh2-dCas9 with KRAB-dCas9 enabled long-term repression at some target genes (e.g., SNURF) but not at HER2, at which H3K9me3 and DNA methylation were transiently acquired and subsequently lost. Off-target DNA hypermethylation occurred at many individual CpG sites but rarely at multiple CpGs in a single promoter, consistent with no detectable effect on transcription at the off-target loci tested. Conversely, robust hypermethylation was observed at HER2. We further demonstrated that Ezh2-dCas9 required full-length DNMT3L for maximal activity and that co-targeting DNMT3L was sufficient for persistent repression by Ezh2-dCas9 or KRAB-dCas9.ConclusionsThese data demonstrate that targeting different combinations of histone and DNA methyltransferases is required to achieve maximal repression at different loci. Fine-tuning of targeting tools is a necessity to engineer epigenetic memory at any given locus in any given cell type

Magnification relations in gravitational lensing via multidimensional residue integrals

We investigate the so-called magnification relations of gravitational lensing models. We show that multidimensional residue integrals provide a simple explanation for the existence of these relations, and an effective method of computation. We illustrate the method with several examples, thereby deriving new magnification relations for galaxy lens models and microlensing (point mass lensing).Comment: 16 pages, uses revtex4, submitted to Journal of Mathematical Physic

Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1

Epstein-Barr virus (EBV; human herpesvirus 4) poses major clinical problems worldwide. Following primary infection, EBV enters a form of long-lived latency in B lymphocytes, expressing few viral genes, and it persists for the lifetime of the host with sporadic bursts of viral replication. The switch between latency and replication is governed by the action of a multifunctional viral protein Zta (also called BZLF1, ZEBRA, and Z). Using a global proteomic approach, we identified a host DNA damage repair protein that specifically interacts with Zta: 53BP1. 53BP1 is intimately connected with the ATM signal transduction pathway, which is activated during EBV replication. The interaction of 53BP1 with Zta requires the C-terminal ends of both proteins. A series of Zta mutants that show a wild-type ability to perform basic functions of Zta, such as dimer formation, interaction with DNA, and the transactivation of viral genes, were shown to have lost the ability to induce the viral lytic cycle. Each of these mutants also is compromised in the C-terminal region for interaction with 53BP1. In addition, the knockdown of 53BP1 expression reduced viral replication, suggesting that the association between Zta and 53BP1 is involved in the viral replication cycle

The Galactic Exoplanet Survey Telescope (GEST)

The Galactic Exoplanet Survey Telescope (GEST) will observe a 2 square degree field in the Galactic bulge to search for extra-solar planets using a gravitational lensing technique. This gravitational lensing technique is the only method employing currently available technology that can detect Earth-mass planets at high signal-to-noise, and can measure the frequency of terrestrial planets as a function of Galactic position. GEST's sensitivity extends down to the mass of Mars, and it can detect hundreds of terrestrial planets with semi-major axes ranging from 0.7 AU to infinity. GEST will be the first truly comprehensive survey of the Galaxy for planets like those in our own Solar System.Comment: 17 pages with 13 figures, to be published in Proc. SPIE vol 4854, "Future EUV-UV and Visible Space Astrophysics Missions and Instrumentation

On Planetary Companions to the MACHO-98-BLG-35 Microlens Star

We present observations of microlensing event MACHO-98-BLG-35 which reached a peak magnification factor of almost 80. These observations by the Microlensing Planet Search (MPS) and the MOA Collaborations place strong constraints on the possible planetary system of the lens star and show intriguing evidence for a low mass planet with a mass fraction $4\times 10^{-5} \leq \epsilon \leq 2\times 10^{-4}$. A giant planet with $\epsilon = 10^{-3}$ is excluded from 95% of the region between 0.4 and 2.5 $R_E$ from the lens star, where $R_E$ is the Einstein ring radius of the lens. This exclusion region is more extensive than the generic "lensing zone" which is $0.6 - 1.6 R_E$. For smaller mass planets, we can exclude 57% of the "lensing zone" for $\epsilon = 10^{-4}$ and 14% of the lensing zone for $\epsilon = 10^{-5}$. The mass fraction $\epsilon = 10^{-5}$ corresponds to an Earth mass planet for a lensing star of mass \sim 0.3 \msun. A number of similar events will provide statistically significant constraints on the prevalence of Earth mass planets. In order to put our limits in more familiar terms, we have compared our results to those expected for a Solar System clone averaging over possible lens system distances and orientations. We find that such a system is ruled out at the 90% confidence level. A copy of the Solar System with Jupiter replaced by a second Saturn mass planet can be ruled out at 70% confidence. Our low mass planetary signal (few Earth masses to Neptune mass) is significant at the $4.5\sigma$ confidence level. If this planetary interpretation is correct, the MACHO-98-BLG-35 lens system constitutes the first detection of a low mass planet orbiting an ordinary star without gas giant planets.Comment: ApJ, April 1, 2000; 27 pages including 8 color postscript figure

Observations of the Binary Microlens Event MACHO-98-SMC-1 by the Microlensing Planet Search Collaboration

We present the observations of the binary lensing event MACHO-98-SMC-1 conducted at the Mt.~Stromlo 74" telescope by the Microlensing Planet Search (MPS) collaboration. The MPS data constrain the first caustic crossing to have occurred after 1998 June 5.55 UT and thus directly rule out one of the two fits presented by the PLANET collaboration (model II). This substantially reduces the uncertainty in the the relative proper motion estimations of the lens object. We perform joint binary microlensing fits of the MPS data together with the publicly available data from the EROS, MACHO/GMAN and OGLE collaborations. We also study the binary lens fit parameters previously published by the PLANET and MACHO/GMAN collaborations by using them as initial values for $\chi^2$ minimization. Fits based on the PLANET model I appear to be in conflict with the GMAN-CTIO data. From our best fit, we find that the lens system has a proper motion of \mu = 1.3\pm 0.2 \kmsk with respect to the source, which implies that the lens system is most likely to be located in the Small Magellanic Cloud strengthening the conclusion of previous reports.Comment: 20 pages, 4 color figure