Development of a high-altitude airborne dial system: The Lidar Atmospheric Sensing Experiment (LASE)

The ability of a Differential Absorption Lidar (DIAL) system to measure vertical profiles of H2O in the lower atmosphere was demonstrated both in ground-based and airborne experiments. In these experiments, tunable lasers were used that required real-time experimenter control to locate and lock onto the atmospheric H2O absorption line for the DIAL measurements. The Lidar Atmospheric Sensing Experiment (LASE) is the first step in a long-range effort to develop and demonstrate an autonomous DIAL system for airborne and spaceborne flight experiments. The LASE instrument is being developed to measure H2O, aerosol, and cloud profiles from a high-altitude ER-2 (extended range U-2) aircraft. The science of the LASE program, the LASE system design, and the expected measurement capability of the system are discussed

Criminal narrative experience: relating emotions to offence narrative roles during crime commission

A neglected area of research within criminality has been that of the experience of the offence for the offender. The present study investigates the emotions and narrative roles that are experienced by an offender while committing a broad range of crimes and proposes a model of Criminal Narrative Experience (CNE). Hypotheses were derived from the Circumplex of Emotions (Russell, 1997), Frye (1957), Narrative Theory (McAdams, 1988) and its link with Investigative Psychology (Canter, 1994). The analysis was based on 120 cases. Convicted for a variety of crimes, incarcerated criminals were interviewed and the data were subjected to Smallest Space Analysis (SSA). Four themes of Criminal Narrative Experience (CNE) were identified: Elated Hero, Calm Professional, Distressed Revenger and Depressed Victim in line with the recent theoretical framework posited for Narrative Offence Roles (Youngs & Canter, 2012). The theoretical implications for understanding crime on the basis of the Criminal Narrative Experience (CNE) as well as practical implications are discussed

Performance-based building and innovation: Balancing client and industry needs

One reason for the interest in performance-based building is that it is commonly advocated as a powerful way of enhancing innovation performance by articulating building performance outcomes, and by offering relevant procurement actors the discretion to innovate to meet these performance requirements more effectively and/or efficiently. The paper argues that the current approach to performance-based building assumes that relevant actors have the capacity, ability and motivation to innovate from a business perspective. It is proposed that the prevailing conceptualization of PBB is too restrictive and should be broadened explicitly to accommodate the required business logic that must be in place before actors will innovate. The relevant performance-based building and innovation literature is synthesized to support the assertion. The paper concludes with an innovation-focused definition of performance-based building

A sentiment analysis approach to increase authorship identification

Writing style is considered the manner in which an author expresses his thoughts, influenced by language characteristics, period, school, or nation. Often, this writing style can identify the author. One of the most famous examples comes from 1914 in Portuguese literature. With Fernando Pessoa and his heteronyms Alberto Caeiro, alvaro de Campos, and Ricardo Reis, who had completely different writing styles, led people to believe that they were different individuals. Currently, the discussion of authorship identification is more relevant because of the considerable amount of widespread fake news in social media, in which it is hard to identify who authored a text and even a simple quote can impact the public image of an author, especially if these texts or quotes are from politicians. This paper presents a process to analyse the emotion contained in social media messages such as Facebook to identify the author's emotional profile and use it to improve the ability to predict the author of the message. Using preprocessing techniques, lexicon-based approaches, and machine learning, we achieved an authorship identification improvement of approximately 5% in the whole dataset and more than 50% in specific authors when considering the emotional profile on the writing style, thus increasing the ability to identify the author of a text by considering only the author's emotional profile, previously detected from prior texts.FCT has supported this work – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are necessary but not sufficient to produce invasive breast cancer because intraductal tumour growth is also constrained by hypoxia and acidosis that develop as cells proliferate into the lumen and away from the underlying vessels. This requires evolution of glycolytic and acid-resistant phenotypes that, we hypothesise, is critical for emergence of invasive cancer. Mathematical models demonstrate severe hypoxia and acidosis in regions of intraductal tumours more than 100 m from the basement membrane. Subsequent evolution of glycolytic and acid-resistant phenotypes leads to invasive proliferation. Multicellular spheroids recapitulating ductal carcinoma in situ (DCIS) microenvironmental conditions demonstrate upregulated glucose transporter 1 (GLUT1) as adaptation to hypoxia followed by growth into normoxic regions in qualitative agreement with model predictions. Clinical specimens of DCIS exhibit periluminal distribution of GLUT-1 and Na+/H+ exchanger (NHE) indicating transcriptional activation by hypoxia and clusters of the same phenotype in the peripheral, presumably normoxic regions similar to the pattern predicted by the models and observed in spheroids. Upregulated GLUT-1 and NHE-1 were observed in microinvasive foci and adjacent intraductal cells. Adaptation to hypoxia and acidosis may represent key events in transition from in situ to invasive cancer

Electron paramagnetic resonance and other properties of hydrogenases isolated from Desulfovibrio vulgaris (strain Hildenborough) and Megasphaera elsdenii

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65872/1/j.1432-1033.1983.tb07727.x.pd

Healthcare designers’ use of prescriptive and performance-based approaches

In the UK, healthcare built environment design is guided by a series of long-established design standards and guidance issued by the Department of Health. More recently, healthcare design focus has broadened to encompass new approaches, supported by large bodies of credible research evidence. It is therefore timely to rethink how healthcare design standards and guidance should be best expressed to suit ‘designerly ways’ of using evidence, to improve their use and effectiveness in practice. This research explored how designers use performance and prescriptive approaches during the healthcare design process. Three in-depth healthcare built environment case studies were used to explore how designers employed such approaches during the design of selected exemplar design elements. Results show that design elements in the pre and conceptual design phases significantly employed performance-based approaches, and due to project-unique circumstances, prescriptive solutions were often significantly modified based on performance criteria. For design elements in the detailed and technical design phases, there was a significant use of solutions based on prescriptive approaches, whilst performance-based criteria were used to evaluate design solutions. This research proposes a performance-based, specification-driven healthcare design with supplementary prescriptive specifications provided for optimum healthcare environment design