Sintered aluminium heat pipe (SAHP)

This work is the product of an ongoing PhD project in the School of the Built and Natural Environment of Northumbria University in collaboration with the University of Liverpool and Thermacore Europe Ltd. The achievements at the end of the first year are summarized. The main objective of the project is to develop an aluminum ammonia heat pipe with a sintered wick structure. Currently available ammonia heat pipes mainly use extruded axially grooved aluminum tubes as a capillary wick. There have been a few attempts of employing porous steel or nickel wicks in steel tubes with ammonia as the working fluid (Bai, Lin et al. 2009)although it is a common practice in loop heat pipes but there is no report of aluminum-ammonia heat pipes porous aluminium wick structures. The main barrier is the difficulty of sintering aluminum powders to manufacture porous wicks. So far during this project promising sintered aluminum heat pipe samples have been manufactured using the Selective Laser Melting (SLM) technique with various wick characteristics. This SLM method has proven to be capable of manufacturing very complicated wick structures with different thickness, porosity, permeability and pore sizes in different regions of a heat pipe. In addition the entire heat pipe including the end cap, outer tube wall, wick and the fill tube can be generated in a single process

Methods for the evaluation of alternative disaster warning systems

For each of the methods identified, a theoretical basis is provided and an illustrative example is described. The example includes sufficient realism and detail to enable an analyst to conduct an evaluation of other systems. The methods discussed in the study include equal capability cost analysis, consumers' surplus, and statistical decision theory

Methods for the evaluation of alternative disaster warning systems. Executive summary

Methods for estimating the economic costs and benefits of the transmission-reception and reception-action segments of a disaster warning system (DWS) are described. Methods were identified for the evaluation of the transmission and reception portions of alternative disaster warning systems. Example analyses using the methods identified were performed

Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions

We present novel homobifunctional amine-reactive clickable cross-linkers (CXLs) for investigation of three-dimensional protein structures and protein–protein interactions (PPIs). CXLs afford consolidated advantages not previously available in a simple cross-linker, including (1) their small size and cationic nature at physiological pH, resulting in good water solubility and cell-permeability, (2) an alkyne group for bio-orthogonal conjugation to affinity tags via the click reaction for enrichment of cross-linked peptides, (3) a nucleophilic displacement reaction involving the 1,2,3-triazole ring formed in the click reaction, yielding a lock-mass reporter ion for only clicked peptides, and (4) higher charge states of cross-linked peptides in the gas-phase for augmented electron transfer dissociation (ETD) yields. Ubiquitin, a lysine-abundant protein, is used as a model system to demonstrate structural studies using CXLs. To validate the sensitivity of our approach, biotin-azide labeling and subsequent enrichment of cross-linked peptides are performed for cross-linked ubiquitin digests mixed with yeast cell lysates. Cross-linked peptides are detected and identified by collision induced dissociation (CID) and ETD with linear quadrupole ion trap (LTQ)-Fourier transform ion cyclotron resonance (FTICR) and LTQ-Orbitrap mass spectrometers. The application of CXLs to more complex systems (e.g., in vivo cross-linking) is illustrated by Western blot detection of Cul1 complexes including known binders, Cand1 and Skp2, in HEK 293 cells, confirming good water solubility and cell-permeability

Estimating evaporation from a wet grassland

International audienceWet grasslands are being restored across the UK and Europe to reinstate their high biodiversity following over 50 years of drainage and conversion to arable agriculture. The water balance of many wet grasslands is dominated by precipitation and evaporation and it is essential to quantify evaporation rates to understand the hydrological functioning of wetlands and the implications for water resources in catchments where wetlands are being restored. This paper considers data from direct measurements of evaporation from the Pevensey Levels wet grassland using the eddy correlation method. Equations are derived to predict actual evaporation using meteorological data on the site or from standard meteorological station observations. It was found that evaporation could be estimated reliably from meteorological variables, such as wind speed, temperature and humidity and by water availability. It was also found that when water availability is high, evaporation is high and may exceed reference evaporation values, raising questions over the deployment of the two-step Penman-Monteith model unless reliable crop coefficients and relative evaporation figures can be determined

Perennial Ryegrass Variety Differences in Nutritive Value Characteristics

Animal grazing performance at grass is predominately determined by herbage intake rates, with high yielding dairy cows requiring up to 20 kg/d DM within a limited grazing time (Gibb, 1998). Grass nutritional factors such as seasonal patterns in digestibility and water-soluble carbohydrate levels have been linked to animal productivity (Davies et al., 1991), while sward surface height, herbage mass, bulk density and green leaf mass have been shown to promote high grazing intake (Barrett et al., 2001). Furthermore, fatty acid profiles have been shown to improve the unsaturated fatty acid composition of milk, with potential human health benefits (Parodi, 1997). Recent CAP funding changes are expected to intensify the drive to optimise margin over costs. Given that grazed grass is the cheapest ruminant feed, it is expected that nutritive value characteristics of grass varieties will become increasingly important relative to total productivity, both as a breeding objective and as an evaluation criteria by variety testers and by farmers. This study examined the genetic diversity in such parameters among a wide range of perennial ryegrass (Lolium perenne L.) varieties, as an indicator of the heterogeneity among current varieties and the prospects for improvement by selective breeding

Domestic violence and mental health: a cross-sectional survey of women seeking help from domestic violence support services

Background : Domestic violence and abuse (DVA) are associated with an increased risk of mental illness, but we know little about the mental health of female DVA survivors seeking support from domestic violence services. Objective : To characterize the demography and mental health of women who access specialist DVA services in the United Kingdom and to investigate associations between severity of abuse and measures of mental health and health state utility, accounting for important confounders and moderators. Design : Baseline data on 260 women enrolled in a randomized controlled trial of a psychological intervention for DVA survivors was analyzed. We report prevalence of and associations between mental health status and severity of abuse at the time of recruitment. We used logistic and normal regression models for binary and continuous outcomes, respectively. Mental health measures used were: Clinical Outcomes in Routine Evaluation–Outcome Measure (CORE-OM), Patient Health Questionnaire, Generalized Anxiety Disorder Assessment, and the Posttraumatic Diagnostic Scale (PDS) to measure posttraumatic stress disorder. The Composite Abuse Scale (CAS) measured abuse. Results : Exposure to DVA was high, with a mean CAS score of 56 (SD 34). The mean CORE-OM score was 18 (SD 8) with 76% above the clinical threshold (95% confidence interval: 70–81%). Depression and anxiety levels were high, with means close to clinical thresholds, and all respondents recorded PTSD scores above the clinical threshold. Symptoms of mental illness increased stepwise with increasing severity of DVA. Conclusions : Women DVA survivors who seek support from DVA services have recently experienced high levels of abuse, depression, anxiety, and especially PTSD. Clinicians need to be aware that patients presenting with mental health conditions or symptoms of depression or anxiety may be experiencing or may have experienced DVA. The high psychological morbidity in this population means that trauma-informed psychological support is needed for survivors who seek support from DVA services. Keywords : domestic violence and abuse; intimate partner violence; mental health; posttraumatic stress disorder; anxiety; CORE-OM; depression; women; advocacy (Published: 15 October 2014) Citation : Glob Health Action 2014,  7 : 25519 -  http://dx.doi.org/10.3402/gha.v7.25519 SPECIAL ISSUE : This paper is part of the Special Issue:  Intimate Partner Violence and Mental Health . More papers from this issue can be found at  http://www.globalhealthaction.net SUPPLEMENTARY MATERIAL : To access the supplementary material for this article, please see  Supplementary files  under Article Tool

Distributional Modes for Scalar Field Quantization

We propose a mode-sum formalism for the quantization of the scalar field based on distributional modes, which are naturally associated with a slight modification of the standard plane-wave modes. We show that this formalism leads to the standard Rindler temperature result, and that these modes can be canonically defined on any Cauchy surface.Comment: 15 pages, RevTe

Urinary Metabolites of Polycyclic aromatic Hydrocarbons in Firefighters: a Systematic Review and Meta-Analysis

Firefighters are intermittently exposed to complex, mixed pollutants in random settings. Of those pollutants, PAHs (polycyclic aromatic hydrocarbons) are the most commonly studied and best understood. PAH exposure can occur via multiple routes; therefore, the levels of hydroxylated metabolites of PAHs in urine have been used as a biomonitoring tool for risk assessment. We performed a systematic review and meta-analysis of the literature to estimate the levels of urinary hydroxylated PAH (OHPAH) among firefighters, determine risk attributions, and, finally, evaluate the scope of preventive efforts and their utility as diagnostic tools. The meta-regression confirmed increases in OHPAH concentrations after fire activities by up to 1.71-times (p-values

Psychological advocacy towards healing (PATH): A randomized controlled trial of a psychological intervention in a domestic violence service setting

Background Experience of domestic violence and abuse (DVA) is associated with mental illness. Advocacy has little effect on mental health outcomes of female DVA survivors and there is uncertainty about the effectiveness of psychological interventions for this population. Objective To test effectiveness of a psychological intervention delivered by advocates to DVA survivors. Design, masking, setting, participants Pragmatic parallel group individually randomized controlled trial of normal DVA advocacy vs. advocacy + psychological intervention. Statistician and researchers blinded to group assignment. Setting: specialist DVA agencies; two UK cities. Participants: Women aged 16 years and older accessing DVA services. Intervention Eight specialist psychological advocacy (SPA) sessions with two follow up sessions. Measurements Primary outcomes at 12 months: depression symptoms (PHQ-9) and psychological distress (CORE-OM). Primary analysis: intention to treat linear (logistic) regression model for continuous (binary) outcomes. Results 263 women recruited (78 in shelter/refuge, 185 in community), 2 withdrew (1 community, control group; 1 intervention, refuge group), 1 was excluded from the study for protocol violation (community, control group), 130 in intervention and 130 in control groups. Recruitment ended June 2013. 12-month follow up: 64%. At 12-month follow up greater improvement in mental health of women in the intervention group. Difference in average CORE-OM score between intervention and control groups: -3.3 points (95% CI -5.5 to -1.2). Difference in average PHQ-9 score between intervention and control group: -2.2 (95% CI -4.1 to -0.3). At 12 months, 35% of the intervention group and 55% of the control group were above the CORE-OM -2clinical threshold (OR 0.32, 95% CI 0.16 to 0.64); 29% of the intervention group and 46% of the control group were above the PHQ-9 clinical threshold (OR 0.41, 95% CI 0.21 to 0.81). Limitations 64% retention at 12 months Conclusions An eight-session psychological intervention delivered by DVA advocates produced clinically relevant improvement in mental health outcomes compared with normal advocacy care. Trial registration ISRCTN registry ISRCTN58561170 Original Research 3675/375