43 research outputs found
A transmembrane c-terminal fragment of syndecan-1 is generated by proteolytic shedding and promotes lung epithelial tumor cell migration and lung metastasis formation
No full textA-Disintegrin and metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells
No full textIt has been proposed that gliomas contain a subpopulation of 'Brain Tumor Stem Cells' (BTSCs), which demonstrate resistance to conventional therapies. A potential component of the environment governing the behavior of these BTSCs is a class of transmembrane proteins with structural and signaling functions, the A-Disintegrin And Metalloproteases (ADAMs). In this study we confirm overexpression of ADAM10 and 17 in human glioma tissue compared to human controls, and especially in tumor sphere cultures thought to enrich for BTSCs. Inhibition of ADAM10/17 function impairs the growth of tumor spheres with evidence of depletion of the sphere forming cell population. This results from a combination of reduced proliferation, cell death and a switch of sphere-forming cells away from symmetric self-renewal division towards neuronal differentiation. A developing appreciation of the role of ADAMs in BTSC promises insights into pathophysiology and potential therapeutic avenues in this intractable group of tumors
Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation
No full textDiscovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
No full textTACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association
No full textGene silencing of TACE enhances plaque stability and improves vascular remodeling in a rabbit model of atherosclerosis
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