Simulation System for the Wendelstein 7-X Safety Control System

The Wendelstein 7-X (W7-X) Safety Instrumented System (SIS) ensures personal safety and investment protection. The development and implementation of the SIS are based on the international safety standard for the process industry sector, IEC 61511. The SIS exhibits a distributed and hierarchical organized architecture consisting of a central Safety System (cSS) on the top and many local Safety Systems (lSS) at the bottom. Each technical component or diagnostic system potentially hazardous for the staff or for the device is equipped with an lSS. The cSS is part of the central control system of W7-X. Whereas the lSSs are responsible for the safety of each individual component, the cSS ensures safety of the whole W7-X device. For every operation phase of the W7-X experiment hard- and software updates for the SIS are mandatory. New components with additional lSS functionality and additional safety signals have to be integrated. Already established safety functions must be adapted and new safety functions have to be integrated into the cSS. Finally, the safety programs of the central and local safety systems have to be verified for every development stage and validated against the safety requirement specification. This contribution focuses on the application of a model based simulation system for the whole SIS of W7-X. A brief introduction into the development process of the SIS and its technical realization will be give followed by a description of the design and implementation of the SIS simulation system using the framework SIMIT (Siemens). Finally, first application experiences of this simulation system for the preparation of the SIS for the upcoming operation phase OP 1.2b of W7-X will be discussed

A GBT Survey of the HALOGAS Galaxies and Their Environments I: Revealing the full extent of HI around NGC891, NGC925, NGC4414 & NGC4565

We present initial results from a deep neutral hydrogen (HI) survey of the HALOGAS galaxy sample, which includes the spiral galaxies NGC891, NGC925, NGC4414, and NGC4565, performed with the Robert C. Byrd Green Bank Telescope (GBT). The resulting observations cover at least four deg$^2$ around these galaxies with an average 5$\sigma$ detection limit of 1.2$\times$10$^{18}$ cm$^{-2}$ over a velocity range of 20 km s$^{-1}$ and angular scale of 9.1$'$. In addition to detecting the same total flux as the GBT data, the spatial distribution of the GBT and original Westerbork Synthesis Radio Telescope (WSRT) data match well at equal spatial resolutions. The HI mass fraction below HI column densities of 10$^{19}$ cm$^{-2}$ is, on average, 2\%. We discuss the possible origins of low column density HI of nearby spiral galaxies. The absence of a considerable amount of newly detected HI by the GBT indicates these galaxies do not have significant extended diffuse HI structures, and suggests future surveys planned with the SKA and its precursors must go \textit{at least} as deep as 10$^{17}$ cm$^{-2}$ in column density to significantly increase the probability of detecting HI associated with the cosmic web and/or cold mode accretion.Comment: Accepted for publication in The Astrophysical Journal; 28 pages, 15 figure

Conventional and regulatory CD4+ T cells that share identical TCRs are derived from common clones

Results from studies comparing the diversity and specificity of the TCR repertoires expressed by conventional (Tconv) and regulatory (Treg) CD4+ T cell have varied depending on the experimental system employed. We developed a new model in which T cells express a single fixed TCRα chain, randomly rearranged endogenous TCRβ chains, and a Foxp3-GFP reporter. We purified CD4+Foxp3- and CD4+Foxp3+ cells, then performed biased controlled multiplex PCR and high throughput sequencing of endogenous TCRβ chains. We identified >7,000 different TCRβ sequences in the periphery of 5 individual mice. On average, ~12% of TCR sequences were expressed by both conventional and regulatory populations within individual mice. The CD4+ T cells that expressed shared TCR sequences were present at higher frequencies compared to T cells expressing non-shared TCRs. Furthermore, nearly all (>90%) of the TCR sequences that were shared within mice were identical at the DNA sequence level, indicating that conventional and regulatory T cells that express shared TCRs are derived from common clones. Analysis of TCR repertoire overlap in the thymus reveals that a large proportion of Tconv and Treg sharing observed in the periphery is due to clonal expansion in the thymus. Together these data show that there are a limited number of TCR sequences shared between Tconv and Tregs. Also, Tconv and Tregs sharing identical TCRs are found at relatively high frequencies and are derived from common progenitors, of which a large portion are generated in the thymus

A Census of the Extended Neutral Hydrogen around 18 MHONGOOSE Galaxies

We present the analysis of the diffuse, low column density H I environment of 18 MHONGOOSE galaxies. We obtained deep observations with the Robert C. Byrd Green Bank Telescope and reached down to a 3σ column density detection limit of NHI = 6.3 × 1017 cm-2 over a 20 km s-1 line width. We analyze the environment around these galaxies, with a focus on H I gas that reaches column densities below NHI = 1019 cm-2. We calculate the total amount of H I gas in and around the galaxies, revealing that nearly all of these galaxies contained excess H I outside of their disks. We quantify the amount of diffuse gas in the maps of each galaxy, defined by H I gas with column densities below 1019 cm-2, and find a large spread in percentages of diffuse gas. However, by binning the percentage of diffuse H I into quarters, we find that the bin with the largest number of galaxies is the lowest quartile (0%-25% diffuse H I). We identified several galaxies that may be undergoing gas accretion onto the galaxy disk using multiple methods of analysis, including azimuthally averaging column densities beyond the disk, and identifying structure within our integrated intensity (moment 0) maps. We measured H I mass outside the disks of most of our galaxies, with rising cumulative flux even at large radii. We also find a strong correlation between the fraction of diffuse gas in a galaxy and its baryonic mass, and we test this correlation using both Spearman and Pearson correlation coefficients. We see evidence of a dark matter halo mass threshold of Mhalo ∼ 1011.1 M⊙ in which galaxies with high fractions of diffuse H I all reside below. It is in this regime that cold-mode accretion should dominate. Finally, we suggest a rotation velocity of vrot ∼ 80 km s-1 as an upper threshold to find diffuse-gas-dominated galaxies

Collinear helium under periodic driving: stabilization of the asymmetric stretch orbit

The collinear eZe configuration of helium, with the electrons on opposite sides of the nucleus, is studied in the presence of an external electromagnetic (laser or microwave) field. We show that the classically unstable "asymmetric stretch" orbit, on which doubly excited intrashell states of helium with maximum interelectronic angle are anchored, can be stabilized by means of a resonant driving where the frequency of the electromagnetic field equals the frequency of Kepler-like oscillations along the orbit. A static magnetic field, oriented parallel to the oscillating electric field of the driving, can be used to enforce the stability of the configuration with respect to deviations from collinearity. Quantum Floquet calculations within a collinear model of the driven two-electron atom reveal the existence of nondispersive wave packets localized on the stabilized asymmetric stretch orbit, for double excitations corresponding to principal quantum numbers of the order of N > 10.Comment: 13 pages, 12 figure

Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

<p>Abstract</p> <p>Background</p> <p>The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts.</p> <p>Methods</p> <p>Thirty Achilles tendinopathy patients were randomized to an expression-study (<it>n </it>= 16) or a structural-study (<it>n </it>= 14). Biopsies from two areas in the Achilles tendon were taken and structural parameters: fibril density, fibril size, volume fraction of cells and the nucleus/cytoplasm ratio of cells were determined. Further gene expressions of various genes were analyzed.</p> <p>Results</p> <p>Significantly smaller collagen fibrils and a higher volume fraction of cells were observed in the tendinopathic region of the tendon. Markers for collagen and its synthesis collagen 1, collagen 3, fibronectin, tenascin-c, transforming growth factor-β fibromodulin, and markers of collagen breakdown matrix metalloproteinase-2, matrix metalloproteinase-9 and metallopeptidase inhibitor-2 were significantly increased in the tendinopathic region. No altered expressions of markers for fibrillogenesis, inflammation or wound healing were observed.</p> <p>Conclusion</p> <p>The present study indicates that an increased expression of factors stimulating the turnover of connective tissue is present in the diseased part of tendinopathic tendons, associated with an increased number of cells in the injured area as well as an increased number of smaller and thinner fibrils in the diseased tendon region. As no fibrillogenesis, inflammation or wound healing could be detected, the present data supports the notion that tendinopathy is an ongoing degenerative process.</p> <p>Trial registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN20896880">ISRCTN20896880</a></p

Critical features in electromagnetic anomalies detected prior to the L'Aquila earthquake

Electromagnetic (EM) emissions in a wide frequency spectrum ranging from kHz to MHz are produced by opening cracks, which can be considered as the so-called precursors of general fracture. We emphasize that the MHz radiation appears earlier than the kHz in both laboratory and geophysical scale. An important challenge in this field of research is to distinguish characteristic epochs in the evolution of precursory EM activity and identify them with the equivalent last stages in the earthquake (EQ) preparation process. Recently, we proposed the following two epochs/stages model: (i) The second epoch, which includes the finally emerged strong impulsive kHz EM emission is due to the fracture of the high strength large asperities that are distributed along the activated fault sustaining the system. (ii) The first epoch, which includes the initially emerged MHz EM radiation is thought to be due to the fracture of a highly heterogeneous system that surrounds the family of asperities. A catastrophic EQ of magnitude Mw = 6.3 occurred on 06/04/2009 in central Italy. The majority of the damage occurred in the city of L'Aquila. Clear kHz - MHz EM anomalies have been detected prior to the L'Aquila EQ. Herein, we investigate the seismogenic origin of the detected MHz anomaly. The analysis in terms of intermittent dynamics of critical fluctuations reveals that the candidate EM precursor: (i) can be described in analogy with a thermal continuous phase transition; (ii) has anti-persistent behaviour. These features suggest that the emerged candidate precursor could be triggered by microfractures in the highly disordered system that surrounded the backbone of asperities of the activated fault. We introduce a criterion for an underlying strong critical behavior.Comment: 8 pages, 6 figure