100 research outputs found
The influence of event characteristics and actors' behaviour on the outcome of violent events: comparing lethal with non-lethal events
Criminal Justice: Legitimacy, accountability, and effectivit
Crime among irregular immigrants and the influence of internal border control
Both the number of crime suspects without legal status and the number of irregular or undocumented immigrants held in detention facilities increased substantially in theNetherlands between 1997 and 2003. In this period, theDutch state increasingly attempted to exclude irregular immigrants from the formal labour market and public provisions. At the same time the registered crime among irregular migrants rose. The 'marginalisation thesis' asserts that a larger number of migrants have become involved in crime in response to a decrease in conventional life chances. Using police and administrative data, the present study takes four alternative interpretations into consideration based on: 1) reclassification of immigrant statuses by the state and redefinition of the law, 2) criminal migration and crossborder crime, 3) changes in policing, and 4) demographic changes. A combination of factors is found to have caused the rise in crime, but the marginalisation thesis still accounts for at least 28%. These findings accentuate the need for a more thorough discussion on the intended and unintended consequences of border control for immigrant crime
Ethnic profiling in the Netherlands? A reflection on expanding preventive powers, ethnic profiling and a changing social and political context
Criminal Justice: Legitimacy, accountability, and effectivit
Neoadjuvant nivolumab and nivolumab plus ipilimumab induce (near-) complete responses in patients with head and neck squamous cell carcinoma:The IMCISION trial
BackgroundNivolumab (NIVO) alone or with ipilimumab (COMBO) immune checkpoint blockade (ICB) prior to curative surgery has shown promising results in multiple tumor types. We completed a phase Ib/II study with neoadjuvant NIVO or COMBO in resectable head and neck squamous cell carcinoma (HNSCC) and show safety, efficacy and correlative biomarker results.Methods32 stage II-IVB HNSCC patients indicated for curative (salvage) surgery were treated with NIVO (240mg, weeks 1&3, N=6) or NIVO (240mg, weeks 1&3) + IPI (1mg/kg, week 1, N=26) prior to surgery in week 5. Imaging was performed at baseline and week 4. AEs were reported in terms of CTCAE. Pathological response (pR) was defined as % change in viable tumor cells from baseline to on-treatment; ≥90% pR was considered (near-) complete response (pCR). WES and RNAseq were performed on paired tumor biopsies.Results32 (31 HPV-negative) patients started treatment (stage II n=3, III n=8, IVA-B n=11, recurrent disease n=10). 6 patients included with recurrent disease had had previous (C)RT. 1 patient discontinued ICB after one course due to patient’s preference. Surgery was not postponed in any patient. 3/32 patients did not undergo surgery: 1 due to unresectable PD and 2 due to reasons unrelated to ICB or disease. Grade 3-4 irAEs in 11/32 patients were well manageable. (Near-)pCR in the primary tumor was seen in 9/29 evaluable patients (31%). Another 31% of patients had 20-89% pR. At 14 months median FU, RFS for patients with (near-)pCR was 100%, significantly better than patients with <90% pR (p=<0.05). Metabolic response assessment with FDG-PET (week 4) was able to identify (near-)pCRs. A baseline AID/APOBEC-associated tumor mutational profile was correlated with (near)pCR (p=<0.05). Finally, (near)pCR tumors were characterized by a decrease in hypoxia gene expression after ICB.ConclusionsNeoadjuvant ICB was feasible in HNSCC and induced (near)pCR in 31% of evaluable patients at time of surgery, which was accompanied by 100% RFS. Baseline AID/APOBEC-related mutations, on-treatment FDG-PET and resolution of hypoxia need future validation to discover their potential role as biomarkers for (near)pCR after ICB in HNSCC
Pseudovector vs. pseudoscalar coupling in one-boson exchange NN potentials
We examine the effects of pseudoscalar and pseudovector coupling of the pi
and eta mesons in one-boson exchange models of the NN interaction using two
approaches: time-ordered perturbation theory unitarized with the relativistic
Lippmann-Schwinger equation, and a reduced Bethe-Salpeter equation approach
using the Thompson equation. Contact terms in the one-boson exchange amplitudes
in time-ordered perturbation theory lead naturally to the introduction of
s-channel nucleonic cutoffs for the interaction, which strongly suppresses the
far off-shell behavior of the amplitudes in both approaches. Differences
between the resulting NN predictions of the various models are found to be
small, and particularly so when coupling constants of the other mesons are
readjusted within reasonable limits.Comment: 24 pages, 4 figure
Shadow Places: Patterns of Spatial Concentration and Incorporation of Irregular Immigrants in the Netherlands
Summary: In Western countries, irregular immigrants constitute a sizeable segment of the population. By combining quantitative and qualitative research methods, this article describes and explains irregular immigrants’ patterns of spatial concentration and incorporation in the Netherlands. So far these spatial patterns have not been described and explained systematically,
neither in the Netherlands nor elsewhere. The article shows that illegal residence is selectively embedded in the (urban) social structure in various ways. The authors argue that irregular
immigrants are likely to be spatially concentrated and incorporated in similar ways in other Western countries; now and in the foreseeable future
The high-precision, charge-dependent Bonn nucleon-nucleon potential (CD-Bonn)
We present a charge-dependent nucleon-nucleon (NN) potential that fits the
world proton-proton data below 350 MeV available in the year of 2000 with a
chi^2 per datum of 1.01 for 2932 data and the corresponding neutron-proton data
with chi^2/datum = 1.02 for 3058 data. This reproduction of the NN data is more
accurate than by any phase-shift analysis and any other NN potential. The
charge-dependence of the present potential (that has been dubbed `CD-Bonn') is
based upon the predictions by the Bonn Full Model for charge-symmetry and
charge-independence breaking in all partial waves with J <= 4. The potential is
represented in terms of the covariant Feynman amplitudes for one-boson exchange
which are nonlocal. Therefore, the off-shell behavior of the CD-Bonn potential
differs in a characteristic and well-founded way from commonly used local
potentials and leads to larger binding energies in nuclear few- and many-body
systems, where underbinding is a persistent problem.Comment: 69 pages (RevTex) including 20 tables and 9 figures (ps files
‘But the Dutch would call it exploitation’. Crimmigration and the moral economy of the Chinese catering industry in the Netherlands
Beyond crime statistics: the construction and application of a criminogenity monitor in Amsterdam
Criminologists have devoted a great deal of attention to risk factors - also called criminogenic factors - leading to criminal offending. This paper presents a criminogenity monitor which includes 19 risk factors that underlie crime. These factors do not themselves cause criminal behaviour; rather, they must be seen as signals that crimes may be committed. After discussing how the criminogenity monitor was constructed, we apply the risk factors we examined to the situation in Amsterdam, capital city of the Netherlands. The monitor is intended to function particularly as an instrument to rationalise policy-makers' work in targeting and preventing symptoms of crime at three geographical levels: the entire city, its boroughs and its neighbourhoods. © 2012 The Author(s)
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