Recovery of Alumina From Coal Fly Ash By High Temperature Chlorination

The recovery of metals from low value sources will help reduce our national demand for foreign resources. The ash from bituminous type coals contains about 20 percent aluminum oxide and 20 percent iron oxides by weight. Recovery of these metals would provide an alternate source to the ores now used. The iron and aluminum materials in fly ash are recoverable by high temperature chlorination. Passing dry chlorine gas through a bed of nonmagnetic fly ash maintained at 850 to 900 degrees C. chlorinates the iron and aluminum constituents forming volatile compounds which are carried from the bed by the exit gas stream. In exploratory runs, 55 percent of the aluminum has been recovered as aluminum chloride in a nearly silica-free state

The Magnetic Fraction of Coal Fly Ash: Its Separation, Properties, and Utilization

A laboratory-size electromagnetic device has been built to separate the high-iron magnetic fraction from coal fly ash. Fly ash, the fine particulate matter produced when pulverized coal is burned, contains an average of 18 wt. percent iron expressed as Fe2O3 found in a distinctive fraction of finely divided, dense, largely spheroidal particles of high magnetic susceptibility. Seventy to eighty percent of the iron in bituminous coal fly ash is found in this fraction which represents about 20 weight percent or 10 volume percent of the fly ash. In this work the iron-rich fraction has been characterized as to particle size, composition, and density. It appears to have a market potential as a material for preparation of high-density media used in coal washing and other mineral dressing processes. Dense-media material, which costs about $100 per metric ton, is being utilized in increasingly large quantities as the demand for washed coal expands. The magnetic fraction also appears to have potential as a source of iron. If further processing can reduce the silica level found in the fraction as it is separated from the ash, pellets with a composition similar to taconite can be prepared for use as blast furnace feed. Separation and use of this fraction of the coal ash could be profitable for utility companies and could be the beginning of the utilization of the large amount of ash which now constitutes a waste disposal problem

Investigating performance of a scintillation radiation detector design

1 online resource (93 p.) : ill. (chiefly col.)Includes abstract and appendix.Includes bibliographical references (p. 48-51)The Super BigBite Spectrometer project in Hall A of the Thomas Jefferson National Accelerator Facility (JLab) is finalizing the design of a required radiation detector called the Coordinate Detector (CDet) for use in electro-nuclear scattering experiments. The CDet will be composed of two planes of scintillating bars (extruded at Fermilab) containing wavelength shifting (WLS) fibers that absorb scintillation light and transport it to photomultiplier tubes (PMTs) for detection. This thesis reports on measurements made on sample scintillating bars to assist in final decisions related to the detector design. Bars with two surface finishes were tested: (1) a TiO2 coating applied during extrusion; and (2) a machined-at surface subsequently wrapped with 1/4 mm thick aluminized Mylar. Each bar contained two 1 mm WLS fibers. Measurements were made to compare scintillation light output of these two finishes. Longitudinal and transverse measurements were made to determine PMT photoelectron yield dependence. It was found that the TiO2 coating and 1/4 thick aluminized Mylar wrapping performed the same within experimental uncertainty. Longitudinal dependence was consistent with expectations from attenuation in the WLS fibers, while transverse dependence shows a maximum yield near the center of the bar and drop-off closer to the edges

Moments of von Mises and Fisher distributions and applications

The von Mises and Fisher distributions are spherical analogues to the Normal distribution on the unit circle and unit sphere, respectively. The computation of their moments, and in particular the second moment, usually involves solving tedious trigonometric integrals. Here we present a new method to compute the moments of spherical distributions, based on the divergence theorem. This method allows a clear derivation of the second moments and can be easily generalized to higher dimensions. In particular we note that, to our knowledge, the variance-covariance matrix of the three dimensional Fisher distribution has not previously been explicitly computed. While the emphasis of this paper lies in calculating the moments of spherical distributions, their usefulness is motivated by their relationship to population statistics in animal/cell movement models and demonstrated in applications to the modelling of sea turtle navigation, wolf movement and brain tumour growth

Functional outcomes of patients undergoing anterolateral versus anteromedial approaches of the ankle for pilon fractures

Pilon fractures of the distal tibia remain a treatment challenge to orthopedists. Careful preoperative planning is crucial to achieving desirable clinical outcomes, but currently the literature does not reach a consensus on which surgical approach is optimal. This study examines functional outcomes of two of the most common surgical approaches for pilon fractures, the traditional anteromedial approach and the more recently described anterolateral approach. The anterolateral approach is thought to produce better outcomes because of the greater amount of visualization into the articular surface and greater soft tissue coverage for the implant

Paracrine factors released by stem cells of mesenchymal origin and their effects in cardiovascular disease: a systematic review of pre-clinical studies

Mesenchymal stem cell (MSC) therapy has gained significant traction in the context of cardiovascular repair, and have been proposed to exert their regenerative effects via the secretion of paracrine factors. In this systematic review, we examined the literature and consolidated available evidence for the “paracrine hypothesis”. Two Ovid SP databases were searched using a strategy encompassing paracrine mediated MSC therapy in the context of ischemic heart disease. This yielded 86 articles which met the selection criteria for inclusion in this study. We found that the MSCs utilized in these articles were primarily derived from bone marrow, cardiac tissue, and adipose tissue. We identified 234 individual protective factors across these studies, including VEGF, HGF, and FGF2; which are proposed to exert their effects in a paracrine manner. The data collated in this systematic review identifies secreted paracrine factors that could decrease apoptosis, and increase angiogenesis, cell proliferation, and cell viability. These included studies have also demonstrated that the administration of MSCs and indirectly, their secreted factors can reduce infarct size, and improve left ventricular ejection fraction, contractility, compliance, and vessel density. Furthering our understanding of the way these factors mediate repair could lead to the identification of therapeutic targets for cardiac regeneration

The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship between exposure of the growing fetus to maternal depression or antidepressants and DNA methylation at two differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene. Aberrant DNA methylation at the IGF2 and neighboring H19 DMRs has been associated with deregulated IGF2 expression, childhood cancers and several chronic diseases during adulthood. Our study population is comprised of pregnant mothers and their newborns (n = 436), as part of the Newborn Epigenetics Study (NEST). A standardized questionnaire was completed and medical record data were abstracted to ascertain maternal depression and antidepressive drug use. DMR methylation levels in umbilical cord blood leukocytes were quantified using pyrosequencing. From the 436 newborns, laboratory data were obtained for 356 individuals at the IGF2 DMRs, and for 411 individuals at the H19 DMRs; about half of each group was African American or Caucasian. While overall no association between depression and methylation profiles was found, we observed a significant hypermethylation of the H19 DMRs in newborns of African American (n = 177) but not Caucasian (n = 168) mothers who reported the use of antidepressive drugs during pregnancy (β = +6.89, p = 0.01). Of note, our data reveal a race-independent association between smoking during pregnancy and methylation at the IGF2 DMR (+3.05%, p = 0.01). In conclusion, our findings suggest a race-dependent response related to maternal use of antidepressants at one of the IGF2 DMRs in the offspring

The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis

Aging promotes a range of degenerative pathologies characterized by progressive losses of tissue and/or cellular function. Fibrosis is the hardening, overgrowth and scarring of various tissues characterized by the accumulation of extracellular matrix components. Aging is an important predisposing factor common for fibrotic heart and respiratory disease. Age-related processes such as senescence, inflammaging, autophagy and mitochondrial dysfunction are interconnected biological processes that diminish the regenerative capacity of the aged heart and lung and have been shown to play a crucial role in cardiac fibrosis and idiopathic pulmonary fibrosis. This review focuses on these four processes of aging in relation to their role in fibrosis. It has long been established that the heart and lung are linked both functionally and anatomically when it comes to health and disease, with an ever-expanding aging population, the incidence of fibrotic disease and therefore the number of fibrosis-related deaths will continue to rise. There are currently no feasible therapies to treat the effects of chronic fibrosis therefore highlighting the importance of exploring the processes of aging and its role in inducing and exacerbating fibrosis of each organ. The focus of this review may help to highlight potential avenues of therapeutic exploration</p