The Effect of Diffusion on the Particle Spectra in Pulsar Wind Nebulae

A possible way to calculate particle spectra as a function of position in pulsar wind nebulae is to solve a Fokker-Planck transport equation. This paper presents numerical solutions to the transport equation with the processes of convection, diffusion, adiabatic losses, and synchrotron radiation included. In the first part of the paper the steady-state version of the transport equation is solved as a function of position and energy. This is done to distinguish the various effects of the aforementioned processes on the solutions to the transport equation. The second part of the paper deals with a time-dependent solution to the transport equation, specifically taking into account the effect of a moving outer boundary. The paper highlights the fact that diffusion can play a significant role in reducing the amount of synchrotron losses, leading to a modification in the expected particle spectra. These modified spectra can explain the change in the photon index of the synchrotron emission as a function of position. The solutions presented in this paper are not limited to pulsar wind nebulae, but can be applied to any similar central source system, e.g. globular clusters

Hylis foveicollis (Coleoptera: Eucnemidae), een dood-houtkever nieuw voor de Nederlandse fauna

Hylis foveicollis is recorded for the first time from The Netherlands. This beetle is very rare throughout Europe, but it can lokally be found in large numbers under favourable conditions. The larvae develop in soft dead wood and probably feed on fung

Spatial and Temporal Variability of the Gamma Radiation from Earth's Atmosphere during a Solar Cycle

The Solar Maximum Mission satellite's Gamma Ray Spectrometer observed Earth's atmosphere for most of the period 1980-1989. Its 28deg orbit ensured that a range of geomagnetic latitudes (geomagnetic cutoff rigidities) was sampled. We measured the variation with time and rigidity of albedo gamma-ray lines at 1.6 MeV, 2.3 MeV and 4.4 MeV which are diagnostic of Galactic cosmic radiation penetrating the cutoff and of the secondary neutrons produced in the atmosphere. We found that the gamma-ray line intensities varied inversely with solar activity and cutoff rigidity, as expected. The line ratio (1.6 MeV + 2.3 MeV)/4.4 MeV was remarkably constant (close to 0.39) at all times and rigidities; the former two lines are produced by 5-10 MeV secondary neutrons causing excitation and de-excitation of 14N, while the latter is produced by more energetic (>20 MeV) neutrons inducing spallation. We infer that the shape of the secondary neutron energy spectrum is virtually constant everywhere and at all times. We also measured the intensity of the 0.511 MeV electron-positron annihilation line. This line too varies with solar cycle and cutoff rigidity, but its fall-off from low to high rigidity is less marked than that of the nuclear lines. This results from the energy dependences of the cross sections for positron production and for the hadronic processes which which produce secondary neutrons.Comment: 11 pages, 12 figs., J. Geophys. Res. in pres

Clinico-radiological dissociation of disease activity in MS patients: frequency and clinical relevance

Objective: To investigate the prevalence and clinical relevance regarding disability progression in multiple sclerosis patients with a dissociation in clinical and radiological disease expression. / Methods: We prospectively selected patients with early relapsing–remitting multiple sclerosis (MS) or a clinically isolated syndrome (CIS) from the Amsterdam MS cohort. Patients underwent clinical examination at baseline, after 2 years, 6 years and a subset also after 11 years, including the Expanded Disability Status Scale (EDSS), 25-foot walk test (25-FWT) and 9-hole peg test (9-HPT). Brain and spinal cord MRI scans were obtained at baseline and after 2 years. Two years after baseline, patients with dissociation in their clinical and radiological disease progression were identified as: (1) patients with high clinical disease activity (defined by relapses) and low radiological disease activity (defined by white-matter lesions on T2-weighted imaging); or (2) patients with low clinical disease activity and high radiological disease activity. Binary logistic regression analyses were performed to predict disability progression after 6 and 11 years of follow-up. Patients with low clinical and low radiological disease activity were used as the reference group. / Results: The prevalence of clinico-radiological dissociation was low (6.4% had high clinical and low radiological disease activity and 5.1% had a combination of low clinical and high radiological disease activity) compared to 88.5% of patients without a dissociation. Patients with a dissociation of clinical and radiological disease activity did not show a statistically significant difference in risk of disability progression after 6 and 11 years. / Conclusions: A clinico-radiological dissociation is rather a rare phenomenon in MS patients. The clinical relevance of such a dissociation regarding the prediction of disability progression is questionable

Heliospheric Effects on Cosmic-Ray Electrons

Motivated by the success of current modulation models in interpreting the solar modulation of Galactic cosmic-ray nuclei, we consider several effects on cosmic-ray electrons which are new or which have not yet been fully explored. Among these are the contribution of Galactic positrons to the total electron flux, the production of secondary electrons from solar system objects, and the possibility of electrons being accelerated at the solar wind termination shock ("anomalous" cosmic-ray electrons). We find that the first of these provides a natural interpretation of the time variations of Galactic cosmic-ray electrons. Jovian electrons and thermal solar wind electrons may be accelerated to cosmic-ray energies at the termination shock. Such acceleration effects may alter the time-intensity profiles of electrons at Earth, further modifying the interpretation of the electron modulation

Upper cervical cord atrophy is independent of cervical cord lesion volume in early multiple sclerosis: A two-year longitudinal study

Background: Upper cervical cord atrophy and lesions have been shown to be associated with disease and disability progression already in early relapsing-remitting multiple sclerosis (RRMS). However, their longitudinal relationship remains unclear. Objective: To investigate the cross-sectional and longitudinal relation between focal T2 cervical cord lesion volume (CCLV) and regional and global mean upper cervical cord area (UCCA), and their relations with disability. Methods: Over a two-year interval, subjects with RRMS (n = 36) and healthy controls (HC, n = 16) underwent annual clinical and MRI examinations. UCCA and CCLV were obtained from C1 through C4 level. Linear mixed model analysis was performed to investigate the relation between UCCA, CCLV, and disability over time. Results: UCCA at baseline was significantly lower in RRMS subjects compared to HCs (p = 0.003), but did not decrease faster over time (p ≥ 0.144). UCCA and CCLV were independent of each other at any of the time points or cervical levels, and over time. Lower baseline UCCA, but not CCLV, was related to worsening of both upper and lower extremities function over time. Conclusion: UCCA and CCLV are independent from each other, both cross-sectionally and longitudinally, in early MS. Lower UCCA, but not CCLV, was related to increasing disability over time

Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis

Background: Clinical measures in multiple sclerosis (MS) face limitations that may be overcome by utilising smartphone keyboard interactions acquired continuously and remotely during regular typing. Objective: The aim of this study was to determine the reliability and validity of keystroke dynamics to assess clinical aspects of MS. Methods: In total, 102 MS patients and 24 controls were included in this observational study. Keyboard interactions were obtained with the Neurokeys keyboard app. Eight timing-related keystroke features were assessed for reliability with intraclass correlation coefficients (ICCs); construct validity by analysing group differences (in fatigue, gadolinium-enhancing lesions on magnetic resonance imaging (MRI), and patients vs controls); and concurrent validity by correlating with disability measures. Results: Reliability was moderate in two (ICC = 0.601 and 0.742) and good to excellent in the remaining six features (ICC = 0.760–0.965). Patients had significantly higher keystroke latencies than controls. Latency between key presses correlated the highest with Expanded Disability Status Scale (r = 0.407) and latency between key releases with Nine-Hole Peg Test and Symbol Digit Modalities Test (ρ = 0.503 and r = −0.553, respectively), ps < 0.001. Conclusion: Keystroke dynamics were reliable, distinguished patients and controls, and were associated with clinical disability measures. Consequently, keystroke dynamics are a promising valid surrogate marker for clinical disability in MS