Land use, associated eel production, and abundance of fish and crayfish in streams in Waikato, New Zealand

The density and biomass of fish and crayfish, and the production of eels, was compared among streams in native forest, exotic forest, and pasture. Populations were estimated by multiple-pass electroshocking at 11 sites in hill-country streams in the Waikato region, North Island. Three sites were in native forest, four in exotic forest, and four in pasture. Length of stream sampled at each site was 46-94 m (41-246 m2 in area), and catchment areas up stream of the sites ranged from 0.44 to 2.01 km2. A total of 487 fish were caught. The species were longfinned and shortfinned eels, banded kokopu, Cran's and redfinned bullies, and common smelt. Eels were the most abundant fish in all three land-use types, and shortfinned eels were more abundant at pastoral sites (mean density 1.11 fish m-2) than longfinned eels (mean density 0.129 fish m-2). Banded kokopu were present only at forested sites. Mean fish densities were greater at pastoral sites (1.55 fish m-2) than under either native forest (0.130 fish m-2) or exotic forest (0.229 fish m-2). Mean fish biomass was also greater at pastoral sites (89.7 g m-2) than under native forest (12.8 g m-2) or exotic forest (19.3 g m-2). Longfinned eels made a greater contribution to the fish biomass at all sites than did shortfinned eels. Densities of crayfish were high (0.46-5.40 crayfish m-2), but were not significantly different between land-use types. Crayfish biomass ranged from 1.79 to 11.2 g m-2. Total eel production was greater at pastoral sites (mean 17.9 g m-2 year-1) than at forest sites (mean 2.39 g m-2 year-1)

MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis

UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples. As there is no clear consensus as to which eradication regimen is most effective, we determined the efficacy of eradication regimens used in our CF centre and long-term clinical outcome. All new MRSA positive sputum cultures (n=37) that occurred between 2000 and 2014 were reviewed. Eradication regimen characteristics and clinical, microbiological and long-term outcome data were collected. Rifampicin plus fusidic acid was the most frequently used regimen (24 (65%) out of 37 patients), with an overall success rate of 79% (19 out of 24 patients). Eradication failure was more likely in patients with an additional MRSA-positive peripheral screening swab (p=0.03) and was associated with worse survival (p=0.04). Our results demonstrate the feasibility and clinical benefits of MRSA eradication. As peripheral colonisation was associated with lower eradication success, strategies combining systemic and topical treatments should be considered to optimise outcomes in CF patients

Lenalidomide, bortezomib and dexamethasone induction therapy for the treatment of newly diagnosed multiple myeloma : a practical review

For patients with newly diagnosed multiple myeloma, survival outcomes continue to improve significantly: however, nearly all patients will relapse following induction treatment. Optimisation of induction therapy is essential to provide longer term disease control and the current standard of care for most patients incorporates an immunomodulatory agent and proteasome inhibitor, most commonly lenalidomide and bortezomib in combination with dexamethasone (RVD), with maintenance until progression. Historically there has been limited access to RVD as an induction strategy outside of the United States; fortunately, there is now increasing access worldwide. This review discusses the rationale for use of RVD as induction therapy and aims to provide guidance in prescribing this regimen in order to optimise efficacy while minimising the toxicities of treatment. We also highlight the increasing evidence for the utility of addition of a monoclonal antibody to the RVD backbone to deepen responses and potentially provide longer disease control.Peer reviewe

Longitudinal study of local authority child and family social workers (wave 1) Findings from a 5 year study of local authority child and family social workers in England.

The longitudinal study investigates recruitment, retention and career progression in local authority child and family social work over 5 years. This is the first of 5 reports. It provides workforce information for employers and policy makers. Topics covered in this report include: •entry routes into local authority child and family social work •current employment and career history •workplace wellbeing •management, supervision and working environment •job satisfaction •career progression and future career plan

The Benard problem: A comparison of finite difference and spectral collocation eigen value solutions

The application of spectral methods, using a Chebyshev collocation scheme, to solve hydrodynamic stability problems is demonstrated on the Benard problem. Implementation of the Chebyshev collocation formulation is described. The performance of the spectral scheme is compared with that of a 2nd order finite difference scheme. An exact solution to the Marangoni-Benard problem is used to evaluate the performance of both schemes. The error of the spectral scheme is at least seven orders of magnitude smaller than finite difference error for a grid resolution of N = 15 (number of points used). The performance of the spectral formulation far exceeded the performance of the finite difference formulation for this problem. The spectral scheme required only slightly more effort to set up than the 2nd order finite difference scheme. This suggests that the spectral scheme may actually be faster to implement than higher order finite difference schemes