Preparación de soportes biomateriales de naturaleza proteica mediante electrohilatura

La electrohilatura se ha postulado como un método sencillo, versátil y escalable a nivel industrial que permite obtener nanofibras por aplicación de un campo eléctrico de alto voltaje entre la punta de una aguja, donde se deposita una gota de solución de un polímero, y un colector metálico. Uno de los campos de aplicación más prometedores de esta tecnología es el enfocado al desarrollo de soportes biomateriales para el sector biomédico. Sin embargo, el control de los parámetros del proceso es clave para la obtención de productos eficaces. En este sentido, este trabajo presenta un estudio sistemático del efecto de los principales parámetros de la electrohilatura que pueden afectar al diámetro de las fibras obtenidas, enfocado específicamente al desarrollo de soportes biomateriales de naturaleza proteica (gelatina y colágeno), por tratarse de substratos de similar naturaleza a los componentes fibrosos encontrados en las matrices extracelulares de los tejidos biológicos. Los resultados obtenidos indican que factores como el tipo de polímero, la concentración, el disolvente y la conductividad del colector tienen una influencia significativa en el diámetro final de las nanofibras. Sin embargo, no se observó influencia en el diámetro cuando se varió el voltaje, caudal y distancia al colector del sistema

Intermatrix synthesis: easy technique permitting preparation of polymer-stabilized nanoparticles with desired composition and structure

The synthesis of polymer-stabilized nanoparticles (PSNPs) can be successfully carried out using intermatrix synthesis (IMS) technique, which consists in sequential loading of the functional groups of a polymer with the desired metal ions followed by nanoparticles (NPs) formation stage. After each metal-loading-NPs-formation cycle, the functional groups of the polymer appear to be regenerated. This allows for repeating the cycles to increase the NPs content or to obtain NPs with different structures and compositions (e.g. core-shell or core-sandwich). This article reports the results on the further development of the IMS technique. The formation of NPs has been shown to proceed by not only the metal reduction reaction (e.g. Cu0-NPs) but also by the precipitation reaction resulting in the IMS of PSNPs of metal salts (e.g. CuS-NPs)

Environmentally-Safe Catalytically Active and Biocide Polymer-Metal Nanocomposites with Enhanced Structural Parameters

Postprint (published version

Intermatrix Synthesis and Characterization of Polymer-Stabilized Functional Metal and Metal Oxide Nanoparticles

Metal oxide nanoparticles (MONPs) are excellent candidates for understanding and controlling the magnetic properties of NPs through the variation of chemistry at the atomic level. In this chapter the authors describe the preparation of Fe3O4 NPs and coat them with silver within various porous polymer matrices, of both anionic and cationic functionality. One of the synthetic advantages of the intermatrix synthesis (IMS) method allows the preparation of various NP architectures. The chapter discusses the synthesis of superparamagnetic core NPs, which are represented by iron oxide NPs. When preparing core-shell NPs, it is important to know the nature of the oxidative states of the metals containing polymer-metal nanocomposites (NCs) in order to determine whether the desired composite has been synthesized. Scanning electron microscopy coupled with an energy-dispersive spectrometer (EDS), is used to characterize the polymer-NP NC material.</p

Characterization of fibrous polymer silver/cobalt nanocomposite with enhanced bactericide activity

This manuscript describes the synthesis (based on the intermatrix synthesis (IMS) method), optimization, and application to bacterial disinfection of Ag@Co polymer metal nanocomposite materials with magnetic and bactericidal properties. This material showed ideal bactericide features for being applied to bacterial disinfection of water, particularly (1) an enhanced bactericidal activity (when compared with other nanocomposites only containing Ag or Co nanoparticles), with a cell viability close to 0% for bacterial suspensions with an initial concentration below 105 colony forming units per milliliter (CFU/mL) after a single pass through the material, (2) capacity of killing a wide range of bacterial types (from coliforms to Grampositive bacteria), and (3) a long performance-time, with an efficiency of 100% (0% viability) up to 1 h of operation and higher than 90% during the first 24 h of continuous operation. The nanocomposite also showed a good performance when applied to water samples from natural sources with more complex matrices with efficiencies always higher than 80%.Peer Reviewe