Polarisation Independent Liquid Crystal Lenses and Contact Lenses using Embossed Reactive Mesogens

Liquid crystal lenses have promise in optical systems owing to their tunability combined with low electrical power, cost, and weight. A good example of such a system is switchable contact lenses for the correction of age‐related presbyopia. Sufficiently large phase modulation can be done using nematic liquid crystals in a meniscus lens configuration. However, the birefringent materials are inherently polarisation dependent, usually requiring orthogonal polarisations to be focussed separately. A novel method is presented for producing polarisation independent lenses based on reactive mesogens. Results are presented for a 2‐level and 3‐level diffractive Fresnel lenses, and the promise of the technique for use in refractive lenses such as contact lenses is discussed

Polarisation Independent Liquid Crystal Lenses using Embossed Reactive Mesogens

Liquid crystal lenses have promise in optical systems owing to their tunability combined with low electrical power, cost and weight. A good example of such a system is switchable contact lenses for the correction of age‐related presbyopia. Large phase modulation can be done using nematic liquid crystals. However, the birefringent materials are inherently polarisation dependent, usually requiring orthogonal polarisations to be focused separately. A novel method is presented for producing polarisation independent lenses based on reactive mesogens

COMMON CURRENCY FOR SYSTEM INTEGRATION OF HIGH INTENSITY ENERGY SUBSYSTEMS

ABSTRACT Aerospace vehicle design has progressed in an evolutionary manner, with certain discrete changes such as turbine engines replacing propellers for higher speeds. The evolution has worked very well for commercial aircraft because the major components can be optimized independently. This is not true for many military configurations which require a more integrated approach. In addition, the introduction of aspects for which there is no pre-existing database requires special attention. Examples of subsystem that have no pre-existing data base include directed energy weapons (DEW) such as high power microwaves (HPM) and high energy lasers (HEL). These devices are inefficient, therefore a large portion of the energy required to operate the device is converted to waste heat and must be transferred to a suitable heat sink. For HPM, the average heat load during one 'shot' is on the same order as traditional subsystems and thus designing a thermal management system is possible. The challenge is transferring the heat from the HPM device to a heat sink. The power density of each shot could be hundreds of megawatts. This heat must be transferred from the HPM beam dump to a sink. The heat transfer must occur at a rate that will support shots in the 10-100Hz range. For HEL systems, in addition to the high intensity, there are substantial system level thermal loads required to provide an "infinite magazine." Present models are inadequate to analyze these problems, current systems are unable to sustain the energy dissipation required and the high intensity heat fluxes applied over a very short duration phenomenon is not well understood. These are examples of potential future vehicle integration challenges. This paper addresses these and other subsystems integration challenges using a common currency for vehicle optimization. Exergy, entropy generation minimization, and energy optimization are examples of methodologies that can enable the creation of energy optimized systems. These approaches allow the manipulation of fundamental equations governing thermodynamics, heat transfer, and fluid mechanics to produce minimized irreversibilities at the vehicle, subsystem and device levels using a common currency. Applying these techniques to design for aircraft system-level energy efficiency would identify not only which subsystems are inefficient but also those that are close to their maximum theoretical efficiency while addressing diverse system interaction and optimal subsystem integration. Such analyses would obviously guide researchers and designers to the areas having the highest payoff and enable departures from the evolutionary process and create a breakthrough design. BACKGROUN

In situ chemically specific mapping of agrochemical seed coatings using stimulated Raman scattering microscopy.

This is the author accepted manuscript. The final version is available from Wiley-VCH-Verlag via the DOI in this record.Providing sufficient, healthy food for the increasing global population is putting a great deal of pressure on the agrochemical industry to maximise crop yields without sustaining environmental damage. The growth and yield of every plant with sexual reproduction, depends on germination and emergence of sown seeds, which is affected greatly by seed disease. This can be most effectively controlled by treating seeds with pesticides before they are sown. An effective seed coating treatment requires a high surface coverage and adhesion of active ingredients onto the seed surface and the addition of adhesive agents in coating formulations plays a key role in achieving this. Although adhesive agents are known to enhance seed germination, little is understood about how they affect surface distribution of actives and how formulations can be manipulated to rationally engineer seed coating preparations with optimized coverage and efficacy. We show, for the first time, that stimulated Raman scattering (SRS) microscopy can be used to map the seed surface with microscopic spatial resolution and with chemical specificity to identify formulation components distributed on the seed surface. This represents a major advance in our capability to rationally engineer seed coating formulations with enhanced efficacy.We thank the funding from the Biotechnology and Biological Sciences Research Council (BBSRC, BB/M017915/1 and BB/K013602/1)

A Single P-loop Glutamate Point Mutation to either Lysine or Arginine Switches the Cation–Anion Selectivity of the CNGA2 Channel

Cyclic nucleotide-gated (CNG) channels play a critical role in olfactory and visual transduction. Site-directed mutagenesis and inside-out patch-clamp recordings were used to investigate ion permeation and selectivity in two mutant homomeric rat olfactory CNGA2 channels expressed in HEK293 cells. A single point mutation of the negatively charged pore loop (P-loop) glutamate (E342) to either a positively charged lysine or arginine resulted in functional channels, which consistently responded to cGMP, although the currents were generally extremely small. The concentration–response curve of the lysine mutant channel was very similar to that of wild-type (WT) channels, suggesting no major structural alteration to the mutant channels. Reversal potential measurements, during cytoplasmic NaCl dilutions, showed that the lysine and the arginine mutations switched the selectivity of the channel from cations (PCl/PNa = 0.07 [WT]) to anions (PCl/PNa = 14 [Lys] or 10 [Arg]). Relative anion permeability sequences for the two mutant channels, measured with bi-ionic substitutions, were NO3− > I− > Br− > Cl− > F− > acetate−, the same as those obtained for anion-selective GABA and glycine channels. The mutant channels also seem to have an extremely small single-channel conductance, measured using noise analysis of about 1–2 pS, compared to a WT value of about 29 pS. The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation–anion selectivity of this channel. However, the outward rectification displayed by both mutant channels in symmetrical NaCl solutions suggests that the negative ends of the pore helix dipoles may play a role in reducing the outward movement of Cl− ions through these anion-selective channels. These results have potential implications for the determinants of anion–cation selectivity in the large family of P-loop–containing channels

ESA Venus Entry Probe Study

The Venus Entry Probe is one of ESA s Technology Reference Studies (TRS). The purpose of the Technology Reference Studies is to provide a focus for the development of strategically important technologies that are of likely relevance for future scientific missions. The aim of the Venus Entry Probe TRS is to study approaches for low cost in-situ exploration of Venus and other planetary bodies with a significant atmosphere. In this paper, the mission objectives and an outline of the mission concept of the Venus Entry Probe TRS are presented

DNA metabarcoding reveals introduced species predominate in the diet of a threatened endemic omnivore, Telfair's skink (Leiolopisma telfairii)

Introduced species can exert disproportionately negative effects on island ecosystems, but their potential role as food for native consumers is poorly studied. Telfair's skinks are endemic omnivores living on Round Island, Mauritius, a globally significant site of biodiversity conservation. We aimed to determine the dietary diversity and key trophic interactions of Telfair's skinks, whether introduced species are frequently consumed, and if diet composition changes seasonally between male and female skinks. We used DNA metabarcoding of skink fecal samples to identify animals (COI) and plants (ITS2) consumed by skinks. There were 389 dietary presence counts belonging to 77 dietary taxa found across the 73 Telfair's skink fecal samples. Introduced taxa were cumulatively consumed more frequently than other categories, accounting for 49.4% of all detections, compared to cryptogenic (20.6%), native (20.6%), and endemic taxa (9.5%). The most frequently consumed introduced species was the ant, Pheidole megacephala, present in 40% of samples. Blue latan palm, Latania loddigesii, was the most frequently consumed endemic species, present in 33% of samples but was only detected in the dry season, when fruits are produced. We found a strong seasonal difference in diet composition explained by the presence of certain plant species solely or primarily in one season and a marked increase in the consumption of animal prey in the dry season. Male and female skinks consumed several taxa at different frequencies. These results present a valuable perspective on the role of introduced species in the trophic network of their invaded ecosystem. Both native and introduced species provide nutritional resources for skinks, and this may have management implications in the context of species conservation and island restoration

Analytic Perturbation Theory: A New Approach to the Analytic Continuation of the Strong Coupling Constant αS\alpha_S into the Timelike Region

The renormalization group applied to perturbation theory is ordinarily used to define the running coupling constant in the spacelike region. However, to describe processes with timelike momenta transfers, it is important to have a self-consistent determination of the running coupling constant in the timelike region. The technique called analytic perturbation theory (APT) allows a consistent determination of this running coupling constant. The results are found to disagree significantly with those obtained in the standard perturbative approach. Comparison between the standard approach and APT is carried out to two loops, and threshold matching in APT is applied in the timelike region.Comment: 16 pages, REVTeX, 7 postscript figure