Buchanan, John, 1869-1965 (SC 1981)

Finding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 1981. Letter from John Buchanan, Louisville, Kentucky, to Allan M. Trout of the Louisville Courier-Journal relating to Colonel J. Stoddard Johnston\u27s claim to have killed Tecumseh

Iowa\u27s Notable Dead …

Obituaries for notable Iowans including lawyer and district judge Milton J. Glenn, legislator and farmer Gustave Alesch, and musician and author Fannie R. Buchanan

Discussion of Recent Decisions

Notes by R. P. Studebaker, David G. MacDonald, J. R. Scott, H. M. Knoth, M. J. Schram, A. Hirsc

Discussion of Recent Decisions

Notes by R. P. Studebaker, David G. MacDonald, J. R. Scott, H. M. Knoth, M. J. Schram, A. Hirsc

Maternal methadone use in pregnancy : factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources

The objectives of this study were to investigate factors associated with the development of neonatal abstinence syndrome (NAS) and to assess the implications for healthcare resources of infants born to drug-misusing women. Design. Retrospective cohort study from 1 January 2004 to 31 December 2006. Setting. Inner-city maternity hospital providing dedicated multidisciplinary care to drug-misusing women. Four hundred and fifty singleton pregnancies of drugmisusing women prescribed substitute methadone in pregnancy. Development of NAS and duration of infant hospital stay. 45.5% of infants developed NAS requiring pharmacological treatment. The odds ratio of the infant developing NAS was independently related to prescribed maternal methadone dose rather than associated polydrug misuse. Breastfeeding was associated with reduced odds of requiring treatment for NAS (OR 0.55, 95% CI 0.34-0.88). Preterm birth did not influence the odds of the infant receiving treatment for NAS. 48.4% infants were admitted to the neonatal unit (NNU) 40% of these primarily for treatment of NAS. The median total hospital stay for all infants was 10 days (interquartile range 7-17 days). Infants born to methadone-prescribed drug-misusing mothers represented 2.9% of hospital births, but used 18.2% of NNU cot days. Higher maternal methadone dose is associated with a higher incidence of NAS. Pregnant drug-misusing women should be encouraged and supported to breastfeed. Their infants are extremely vulnerable and draw heavily on healthcare resources

THE PRAIRIE NATURALIST Volume 22, No. 1 March 1990

Paul B. Kannowski, Editor Nikki R. Seabloom, Assistant Editor Douglas H. Johnson, Book Review Editor CONTENTS DUCK NESTING ON ISLANDS AT J. CLARK SALYER REFUGE IN NORTH DAKOTA, 1983–1984 ▪ A. D. Aufforth, H. Goetz, and K. F. Higgins PRODUCTION OF TALL-GRASS PRAIRIE HERBS BELOW EASTERN REDCEDAR ▪ S. D. Smith and J. Stubbendieck HABITAT BREADTH OF NONGAME RODENTS IN THE MIXED-GRASS PRAIRIE REGION OF NORTH CENTRAL KANSAS ▪ D. W. Kaufman, B. K. Clark, and G. A. Kaufman UNIONID MOLLUSCS IN THE BIG BEND REACH OF THE PLATTE RIVER, NEBRASKA ▪ M. D. Roedel POPULATION CHARACTERISTICS OF ROCK BASS IN THREE NORTHEASTERN SOUTH DAKOTA LAKES ▪ G. C. Hoffman, C. L. Milewski, and D. W. Willis A PROPOSED STANDARD WEIGHT (Ws) EQUATION FOR SAUGER ▪ C. S. Guy, E. A. Bettross, and D. W. Willis USE OF HELICOPTERS FOR SURVEYS OF NESTING RED-SHOULDERED HAWKS ▪ J. G. Cook and S. H. Anderson NOTES Distributional Records of the Great Plains Rat Snake in Dinosaur National Monument ▪ R. M. Engeman and A. Engeman First Record of Nominotypical Incisalia polia (Lepidoptera, Lycaenidae) for North Dakota ▪ R. A. Royer Displacement of White-tailed Deer by Flooding ▪ G. L. Dusek BOOK REVIEWS Common Range Forbs of Nebraska ▪ G. E. Larson North Dakota\u27s Wildflowers ▪ J. Sinner and M. J. Sinner A Potpourri of Predators ▪ D. L. Garshelis EDITORIAL POLICY ▪ Editor SUGGESTIONS FOR CONTRIBUTORS ▪ Editor Mailing Date: March 14, 199

Synthesis of a group of novel Xanomeline/77-LH-28-1 hybrid ligands and their FRET investigation at muscarinic acetylcholine receptor subtypes

In connection with our interest in investigating novel rationally designed bitopic (i.e., orthosteric/allosteric) derivatives targeting muscarinic acetylcholine receptor (mAChR) subtypes (1,2,3), in this study we designed and synthesized a new set of ligands that integrate in the same molecular skeleton the pharmacophoric moieties of Xanomeline and of 77-LH-28-1 (1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone). Xanomeline is a well-known M1/M4-preferring orthosteric agonist, which ameliorated cognitive impairments in Alzheimer\u2019s disease patients and showed activity in various models of schizophrenia, thus being potentially beneficial for treatment of positive, negative and cognitive symptoms (4). On the other hand, 77-LH-28-1 was characterized as an M1-selective, positive allosteric modulator, thus representing an interesting pharmacological tool with cognition enhancing properties (5). As illustrated below, we planned the novel bipharmacophoric derivatives as merged structures, with the tetrahydropyridine nucleus of Xanomeline as the central core. In the last years, different receptor sensors, based on the fluorescence resonance energy transfer (FRET), were generated for various G protein-coupled receptors, and represented a valuable tool to investigate real time receptor activation as well as ligand-receptor interactions. Recently, this analysis was performed also on a set of bitopic ligands designed for a selective interaction with M1 mAChRs (6). Our preliminary results on the group of Xanomeline/77-LH-28-1 hybrid compounds indicate, for the M1 sensor, a reproducible activation response, which depends on the linker length. Conversely, no FRET-related effect could be detected at the M2 sensor. Thus, a critical spacer length of the hybrid compounds induces conformational changes with a degree of selectively for the M1 muscarinic receptor. The synthesis and the results of pharmacological investigation will be presented and discussed. References: 1. J. Antony, K. Kellershohn, M. Mohr-Andr\ue4, A. Kebig, S. Prilla, M. Muth, E. Heller, T. Disingrini, C. Dallanoce et al., FASEB J 2009, 23, 442-450. 2. A. Bock, B. Chirinda, F. Krebs, R. Messerer, J. B\ue4tz, M. Muth, C. Dallanoce et al., Nat. Chem. Biol. 2014, 10, 18-20. 3. A. Bock, M. Bermudez, F. Krebs, C. Matera, B. Chirinda, D. Sydow, C. Dallanoce et al., J. Biol. Chem. 2016, 291, 16375-16389. 4. S. Barak, I. Weiner, Int. J. Neuropsychoph. 2011, 14, 1233-1246. 5. C. J. Langmead, N. E. Austin, C. L. Branch, J. T. Brown, K. A. Buchanan, C. H. Davies, I. T. Forbes et al., Br. J. Pharmacol. 2008, 154, 1104-1115. 6. R. Messerer, M. Kauk, D. Volpato, M. C. Alonso Canizal, J. Kl\uf6ckner, U. Zabel, S. Nuber, C. Hoffmann, U. Holzgrabe, ACS Chem. Biol. 2017, 12, 833-843

Plain Diversity: Amish Cultures and Identities

Review of: "Plain Diversity: Amish Cultures and Identities," by Steven M. Nolt and Thomas J. Meyers

Developing professional learning for staff working with children with speech, language and communication needs combined with moderate-to-severe learning difficulties

Children with speech, language and communication needs (SLCN) often present challenges in interaction where teachers may need specialist knowledge. In this article, Carolyn Anderson of the University of Strathclyde examines how teachers and classroom assistants (N=49) developed their professional learning for working with these pupils. A questionnaire revealed limited evidence of pre or post-qualification training in topics or number of hours teaching relating to SLCN. In the absence of formal learning opportunities, most teachers reported learning from others with experience or from reflecting on their own practice. They valued feedback from peers on their teaching practice. The results suggest that school teams should agree on definitions for reflective practice and feedback and how these contribute to professional learning. Lack of access to or availability of formal learning opportunities may be an important factor in shaping teachers' perceptions of their competence and confidence in working with children who have speech, language and communication needs