Why we kill: understanding violence across cultures and disciplines

Infanticide, serial killings, war, terrorism, abortion, honour killings, euthanasia, suicide bombings and genocide; all involve taking of life. Put most simply, all involve killing one or more other people. Yet cultural context influences heavily how one perceives all of these, and indeed, some readers of this paragraph may already have thought: 'But surely that doesn't belong with those others, that's not really killing.' For such an evolved species, human beings can be violent far beyond the point of inhumanity. Why We Kill: Understanding violence across cultures and disciplines examines this violence in many of its manifestations, exploring how culture plays a role in people's understanding of violent action. From the first chapter, which tries to understand multiple forms of domestic homicide including infanticide, filicide, spousal homicide and honour killings, to the final chapter's bone-chilling account of the massacre at Murambi in Rwanda, this fascinating book makes compelling reading

Disruption of normal body axis formation after teratogen exposure

International audienceUrban transport plans in France (UTPs) aim to develop mobility for everyone and to find a balance between cars, public transport and other transport modes, this in order to favour sustainable mobility. In this article, the question of the utility derived from such policies is raised for the inhabitants of Nantes, which was designated the ‘European Green Capital’ in 2013. We analyse the capitalization of various effects of urban transport policies in housing values. Using a hedonic price model, we show that housing values in Nantes are significantly determined by improved accessibility to the city centre. We highlight contrasting effects of UTPs on housing values depending on the location of apartments and on the mode of public transport. Households also internalize air and noise pollution generated by transportation, but they attach only a low value to pollution exposure

Managing Water under Uncertainty and Risk: The United Nations World Water Development Report 4

This report introduces new aspects of water issues: 1) it reintroduces the 12 challenge area reports that provided the foundation for the first two World Water Development Reports (WWDR); 2) 4 new reports on water quality, groundwater, gender, and desertification, land degradation and drought; 3) in recognition that the global challenges of water can vary considerably across countries and regions, a series of 5 regional reports have been included; 4) a deeper analysis of the main external forces of freshwater resources and possibilities for their future evolution; 5) managing water under uncertainty and risk

A Qualitative Analysis of the Experience of Staff Employed within the Forensic Disability Sector in Victoria, Australia

BACKGROUND: This paper explores the experience of staff employed within forensic disability across Victoria in an attempt to better understand service needs in this field. The complex needs of individuals with disabilities involved in the criminal justice system or presenting with offence-related behaviours suggest that there is a requirement to improve services directed towards forensic disability. METHODS: Four semi-structured group interviews, determined by geographical location, were completed with employees (n = 14) within the Australian Community Support Organisation, with an average of 5 years of forensic disability experience. Data were analysed based on thematic analysis. RESULTS: Five themes were revealed. Three pre-existing themes were emphasized that included client complexity; poor responses from external services; and funding, and two novel themes labelled as staff well-being and responses to risk. CONCLUSIONS: Recommendations include multiagency collaboration, funding forensic disability services, development of best practice initiatives and advocacy

Development of a Regional Fence Model with Implications for Wildlife Management

Barbed and woven wire fence are ubiquitous features across much of western North America, yet their effects on wildlife have received less attention than those of other anthropogenic features. At this time, no geospatial fencing data is available at broad level scales; potentially making wildlife modeling of vagile species less accurate and conservation planning less reliable at various scales. Here, we model fence density across 13 counties in Montana’s Hi-Line region, based on publicly available GIS data and assumptions created from local, expert knowledge. The resulting fence location and density GIS layers are based on assumptions about where fence locations occur in association to different types of land tenure, land cover and roads. Locations of fences were collected via GPS along random 3.2 km long road transects (n = 738) to assess overall model accuracy. Using a confusion matrix to determine variation between field and modeled fence locations, the total accuracy of the model was 73% and Kappa was .40. Although we found inaccuracies associated with large parcels (>3 contiguous sections) of cultivated agriculture, our model is a promising step towards delineating fencing across the west. These general rules may be used and refined in the other areas based on the regional historical context. This new data may advance both wildlife research and management/mitigation activities. Using the relative density of fences across a region can prioritize conservation efforts at this broad scale. In addition, modeled fence locations provide useful and accurate information at a local scale

Evidence-Based Professional Development of Science Teachers in Two Countries

The focus of this collaborative research project of King?s College London, and the Weizmann Institute, Israel. project is on investigating the ways in which teachers can demonstrate accomplished teaching in a specific domain of science and on the teacher learning that is generated through continuing professional development programs (CPD) that lead towards such practice. The interest lies in what processes and inputs are required to help secondary school science teachers develop expertise in a specific aspect of science teaching. `It focuses on the design of the CPD programmes and examines the importance of an evidence-based approach through portfolioconstruction in which professional dialogue pathes the way for teacher learning. The set of papers highlight the need to set professional challenge while tailoring CPD to teachers? needs to create the environment in which teachers can advance and transform their practice. The cross-culture perspective added to the richness of the development and enabled the researchers to examine which aspects were fundamental to the design by considering similarities and differences between the domains

Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States

BACKGROUND: Perchlorate is commonly found in the environment and known to inhibit thyroid function at high doses. Assessing the potential effect of low-level exposure to perchlorate on thyroid function is an area of ongoing research. OBJECTIVES: We evaluated the potential relationship between urinary levels of perchlorate and serum levels of thyroid stimulating hormone (TSH) and total thyroxine (T(4)) in 2,299 men and women, ≥ 12 years of age, participating in the National Health and Nutrition Examination Survey (NHANES) during 2001–2002. METHODS: We used multiple regression models of T(4) and TSH that included perchlorate and covariates known to be or likely to be associated with T(4) or TSH levels: age, race/ethnicity, body mass index, estrogen use, menopausal status, pregnancy status, premenarche status, serum C-reactive protein, serum albumin, serum cotinine, hours of fasting, urinary thiocyanate, urinary nitrate, and selected medication groups. RESULTS: Perchlorate was not a significant predictor of T(4) or TSH levels in men. For women overall, perchlorate was a significant predictor of both T(4) and TSH. For women with urinary iodine < 100 μg/L, perchlorate was a significant negative predictor of T(4) (p < 0.0001) and a positive predictor of TSH (p = 0.001). For women with urinary iodine ≥ 100 μg/L, perchlorate was a significant positive predictor of TSH (p = 0.025) but not T(4) (p = 0.550). CONCLUSIONS: These associations of perchlorate with T(4) and TSH are coherent in direction and independent of other variables known to affect thyroid function, but are present at perchlorate exposure levels that were unanticipated based on previous studies

Cortical dynamics of disfluency in adults who stutter

Citation: Sengupta, R., Shah, S., Loucks, T. M. J., Pelczarski, K., Scott Yaruss, J., Gore, K., & Nasir, S. M. (2017). Cortical dynamics of disfluency in adults who stutter. Physiological Reports, 5(9). doi:10.14814/phy2.13194Stuttering is a disorder of speech production whose origins have been traced to the central nervous system. One of the factors that may underlie stuttering is aberrant neural miscommunication within the speech motor network. It is thus argued that disfluency (any interruption in the forward flow of speech) in adults who stutter (AWS) could be associated with anomalous cortical dynamics. Aberrant brain activity has been demonstrated in AWS in the absence of overt disfluency, but recording neural activity during disfluency is more challenging. The paradigm adopted here took an important step that involved overt reading of long and complex speech tokens under continuous EEG recording. Anomalies in cortical dynamics preceding disfluency were assessed by subtracting out neural activity for fluent utterances from their disfluent counterparts. Differences in EEG spectral power involving alpha, beta, and gamma bands, as well as anomalies in phase-coherence involving the gamma band, were observed prior to the production of the disfluent utterances. These findings provide novel evidence for compromised cortical dynamics that directly precede disfluency in AWS. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.

Background Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease. Methods Cardiomyocytes were isolated from healthy donor hearts, as well as from patients with cardiomyopathies and with left ventricular assist devices. Scanning ion conductance and confocal microscopy was used to study membrane structures in the cells. Super-resolution scanning patch-clamp was used to examine LTCC function in different microdomains. Computational modeling predicted the impact of these changes to arrhythmogenesis at the whole-heart level. Findings We showed that loss of structural organization in failing myocytes leads to re-distribution of functional LTCCs from the T-tubules to the sarcolemma. In ischemic cardiomyopathy, the increased LTCC open probability in the T-tubules depends on the phosphorylation by protein kinase A, whereas in dilated cardiomyopathy, the increased LTCC opening probability in the sarcolemma results from enhanced phosphorylation by calcium-calmodulin kinase II. LVAD implantation corrected LTCCs pathophysiological activity, although it did not improve their distribution. Using computational modeling in a 3D anatomically-realistic human ventricular model, we showed how LTCC location and activity can trigger heart rhythm disorders of different severity. Interpretation Our findings demonstrate that LTCC redistribution and function differentiate between disease aetiologies. The subcellular changes observed in specific microdomains could be the consequence of the action of distinct protein kinases. Funding This work was supported by NIH grant (ROI-HL 126802 to NT-JG) and British Heart Foundation (grant RG/17/13/33173 to JG, project grant PG/16/17/32069 to RAC). Funders had no role in study design, data collection, data analysis, interpretation, writing of the repor

Healthier prisons: The role of a prison visitors' centre

Since the inception of the prison as a ‘setting’ for health promotion, there has been a focus on how the health of those men and women who spend ‘time inside’ can at least be maintained and if possible, enhanced, during their prison sentence. This paper presents findings from a mainly qualitative evaluation of a prison visitors' centre in the UK. It reports experiences of prisoners' families, prisoners, prison staff, the local community and the ways in which the visitors' centre has contributed positively to their health and well-being. In addition, key stakeholders were interviewed to ascertain the role this visitors' centre has in policy frameworks related to re-offending. The findings from this evaluation underscore how the visitors' centre improved the quality of visits, and contributed towards the maintenance of family ties through the help and support it provides for families and prisoners. The paper concludes by suggesting that visitors' centres are an essential part of a modern prison service helping to address the government's health inequalities agenda