Choosing To Thrive: Finding Self And Fulfillment Through My Organizational Dynamics Learning Journey

As I sought a better life for myself, making me first in my family in many ways, I struggled to navigate the uncharted territories of college and the workplace far away from home. I was racked with guilt, shame, and fear about the what-ifs, which held me back from living a more authentic life. Various frameworks from the Organizational Dynamics program and other influential experiences have given me the tools to reposition my thinking more purposefully, and to create a vision for living and to uncover my potential as an instrument of change. I describe the powerful moments that propelled me into wanting to thrive and not just survive. I also share my exploration in learning and identifying with the impostor phenomenon experience

Substantial Red Wolf Genetic Ancestry Persists in Wild Canids of Southwestern Louisiana

Concerns over red wolf (Canis rufus) extinction caused by hybridization with coyotes (C. latrans) led to the capture and removal of remnant wild wolves from southwestern Louisiana and southeastern Texas, United States, during the 1970s. Here we show that despite decades of unmitigated hybridization, and declaration of endangered red wolves as functionally extinct in the wild, red wolf mitochondrial or nuclear DNA ancestry persists in ∼55% of contemporary wild canids sampled in southwestern Louisiana. Surprisingly, one individual had 78–100% red wolf ancestry, which is within the range for 75% red wolf, red wolf backcross, or putative red wolf, depending on estimation method. Our findings bolster support for designation of red wolves as a distinct species, demonstrate a critical need for the United States Government to consider adopting an existing but unimplemented hybrid policy, and suggest that immediate reassessment of canid management and taxonomic designation in southwestern Louisiana may be warranted

A Survey of Speech-language Pathologists: Long-term Speech Therapy Needs for Patients within Three Neurological Conditions

Forty-seven speech-language pathologists (SLPs) completed a written survey designed to obtain their opinions regarding the speech-language pathology needs of patients presenting with communication deficits following traumatic brain injury, cerebrovascular accident and cerebral palsy. Results indicated that over one-half of the SLPs in the study cited the most common reason that speech therapy is stopped is due to lack of insurance coverage, not because the patient reached maximum improvement. After discharge from services, 78-92% of SLPs affirmed that their patients would have benefitted from ongoing speech-language treatment if insurance limitations were not a consideration. In many instances, therapy was recommended for several years up to lifetime follow-up. Study results demonstrate that a common reason for termination of therapy was due to insurance limits, The implications of this pilot study for life care planners pertain to consulting with SLPs regarding what the evaluation and long term speech-language pathology needs may be for patients with these three neurological disorders, without considering insurance limits

Dengue una enfermedad emergente y re-emergente en América

El Dengue es una enfermedad infecciosa, producida por un arbovirus cuyo único reservorio es el hombre. El virusutiliza como vector biológico al mosquito Aedes aegypti o al mosquito Aedes albopictus. La sintomatología se presentahabitualmente como un cuadro febril denominado dengue clásico, que se caracteriza por fiebre alta de presentaciónaguda, de duración limitada (2 a 7 días), con intenso malestar general, acompañado de erupción cutánea. Puedepresentar síntomas hemorrágicos de escasa intensidad, como petequias y sangramiento gingival. El tratamiento essintomático y el paciente mejora completamente en aproximadamente 7 días. Esta forma de dengue no producemortalidad. Sin embargo, existen otras presentaciones de la enfermedad que pueden llegar a manifestaciones graves deltipo hemorrágicas con muerte, lo que se presenta en el 5% de los enfermos. El dengue es un problema creciente desalud pública, que afecta a más de 100 países en el mundo, con más de 50 millones de casos informados cada año. Loscuatro tipos de dengue, están circulando en América, donde los casos aumentaron en los últimos años en formaexplosiva. Si bien, en Chile continental no se ha documentado la existencia del mosquito vector del dengue de formaendémica, si se ha hecho en Chile Insular, más específicamente en Isla de Pascua, donde desde el año 1999, seincorporó a la lista de enfermedades de declaración obligatoria (D.S. Nº 158) estableciendo su vigilancia. Los factoresque han llevado a la emergencia de esta enfermedad son principalmente el cambio climático, que ha modificado elnicho ecológico de los mosquitos de la familia Aedes. También la urbanización, la falta de control del vector, las fallasen infraestructura básica y el pobre saneamiento ambiental. La intervención primaria de salud pública ha ido por la líneadel uso de insecticidas para el control del vector y la detección temprana de casos. No existe aún una vacuna efectiva,sin embargo, actualmente se están realizando esfuerzos en esta materia

Evaluating Otter Reintroduction Outcomes Using Genetic Spatial Capture-Recapture Modified for Dendritic Networks

Monitoring the demographics and genetics of reintroduced populations is critical to evaluating reintroduction success, but species ecology and the landscapes that they inhabit often present challenges for accurate assessments. If suitable habitats are restricted to hierarchical dendritic networks, such as river systems, animal movements are typically constrained and may violate assumptions of methods commonly used to estimate demographic parameters. Using genetic detection data collected via fecal sampling at latrines, we demonstrate applicability of the spatial capture–recapture (SCR) network distance function for estimating the size and density of a recently reintroduced North American river otter (Lontra canadensis) population in the Upper Rio Grande River dendritic network in the southwestern United States, and we also evaluated the genetic outcomes of using a small founder group (n = 33 otters) for reintroduction. Estimated population density was 0.23–0.28 otter/km, or 1 otter/3.57–4.35 km, with weak evidence of density increasing with northerly latitude (β = 0.33). Estimated population size was 83–104 total otters in 359 km of riverine dendritic network, which corresponded to average annual exponential population growth of 1.12–1.15/year since reintroduction. Growth was ≥40% lower than most reintroduced river otter populations and strong evidence of a founder effect existed 8–10 years post-reintroduction, including 13–21% genetic diversity loss, 84%–87% genetic effective population size decline, and rapid divergence from the source population (FST accumulation = 0.06/generation). Consequently, genetic restoration via translocation of additional otters from other populations may be necessary to mitigate deleterious genetic effects in this small, isolated population. Combined with non-invasive genetic sampling, the SCR network distance approach is likely widely applicable to demogenetic assessments of both reintroduced and established populations of multiple mustelid species that inhabit aquatic dendritic networks, many of which are regionally or globally imperiled and may warrant reintroduction or augmentation efforts

Mechanistic stochastic model of histone modification pattern formation

BACKGROUND: The activity of a single gene is influenced by the composition of the chromatin in which it is embedded. Nucleosome turnover, conformational dynamics, and covalent histone modifications each induce changes in the structure of chromatin and its affinity for regulatory proteins. The dynamics of histone modifications and the persistence of modification patterns for long periods are still largely unknown. RESULTS: In this study, we present a stochastic mathematical model that describes the molecular mechanisms of histone modification pattern formation along a single gene, with non-phenomenological, physical parameters. We find that diffusion and recruitment properties of histone modifying enzymes together with chromatin connectivity allow for a rich repertoire of stochastic histone modification dynamics and pattern formation. We demonstrate that histone modification patterns at a single gene can be established or removed within a few minutes through diffusion and weak recruitment mechanisms of histone modification spreading. Moreover, we show that strong synergism between diffusion and weak recruitment mechanisms leads to nearly irreversible transitions in histone modification patterns providing stable patterns. In the absence of chromatin connectivity spontaneous and dynamic histone modification boundaries can be formed that are highly unstable, and spontaneous fluctuations cause them to diffuse randomly. Chromatin connectivity destabilizes this synergistic system and introduces bistability, illustrating state switching between opposing modification states of the model gene. The observed bistable long-range and localized pattern formation are critical effectors of gene expression regulation. CONCLUSION: This study illustrates how the cooperative interactions between regulatory proteins and the chromatin state generate complex stochastic dynamics of gene expression regulation

How to detect late-onset inborn errors of metabolism in patients with movement disorders - A modern diagnostic approach

We propose a modern approach to assist clinicians to recognize and diagnose inborn errors of metabolism (IEMs) in adolescents and adults that present with a movement disorder. IEMs presenting in adults are still largely unexplored. These disorders receive little attention in neurological training and daily practice, and are considered complicated by many neurologists. Adult-onset presentations of IEMs differ from childhood-onset phenotypes, which may lead to considerable diagnostic delay. The identification of adult-onset phenotypes at the earliest stage of the disease is important, since early treatment may prevent or lessen further brain damage. Our approach is based on a systematic review of all papers that concerned movement disorders due to an IEM in patients of 16 years or older. Detailed clinical phenotyping is the diagnostic cornerstone of the approach. An underlying IEM should be suspected in particular in patients with more than one movement disorder, or in patients with additional neurological, psychiatric, or systemic manifestations. As IEMs are all genetic disorders, we recommend next-generation sequencing (NGS) as the first diagnostic approach to confirm an IEM. Biochemical tests remain the first choice in acute-onset or treatable IEMs that require rapid diagnosis, or to confirm the metabolic diagnosis after NGS results. With the use of careful and systematic clinical phenotyping combined with novel diagnostic approaches such as NGS, the diagnostic yield of late-onset IEMs will increase, in particular in patients with mild or unusual phenotypes.</p

Cholestasis and meconium ileus in infants with cystic fibrosis and their clinical outcomes

Objective To identify the incidence and outcomes of cholestasis and meconium ileus (MI) in infants with cystic fibrosis (CF). Design Retrospective cohort study. Setting Single-centre study. Patients From January 1986 to December 2011, 401 infants with CF (69 with MI) presented to our centre. Main outcome measurements (1) incidence of cholestasis, (2) identification of risk factors for cholestasis, (3) association between the presence of cholestasis and MI and the development of clinically significant CF-associated liver disease (CFLD) defined as multilobular cirrhosis with portal hypertension. Results Cholestasis occurred in 23 of 401 infants (5.7%). There was a significantly higher incidence of cholestasis in infants with MI (27.1%) compared to those without MI (1.2%) (p Conclusions Cholestasis is an uncommon condition in CF affecting only 5.7% of the screened newborn CF population. The greatest risk factor for developing cholestasis is the presence of MI. However, the presence of MI appears not to be associated with the development of CFLD. An effect of neonatal cholestasis on the development of CFLD cannot be excluded by this study

Европеизмы как терминологические номинативные единицы в образовании терминосистем татарской юридической терминологии

Цель статьи: выявить особенности адаптации терминоэлементов-европеизмов (слова западно-европейских языков в составе татарского языка)