A forensic geoscience framework and practice

Appropriate and correct collection, analysis, interpretation, and presentation of geoforensic evidence are contingent upon understanding the specific context of the particular forensic investigation undertaken. To achieve this, the role of experimental studies in forensic geoscience must not be underestimated. In this article, we present two experimental studies that assess the spatial distribution of pollen in a living room and the nature of subsequent transfer of pollen onto clothing. The presence of cut flowers in a living room are shown to lead to a distribution of pollen grains onto all types of surface in that room that exhibits a distance–decay pattern with the greatest numbers of grains found in close proximity to the flowers. Once the transfer of pollen grains from a source location onto clothing has taken place, our second study demonstrates the nature of the persistence of that evidence for dry and damp clothing under active and inactive conditions. The level of activity after transfer is shown to have far more influence upon the persistence of this form of geoforensic evidence in comparison to the damp or dry conditions of the garment. We argue that these findings have implications for all stages of the forensic investigation–from sampling protocols to the interpretation of the presence/absence of geoforensic evidence. Whilst every contact does indeed leave a trace, it is imperative that there is an appreciation of the context of each forensic investigation, meaningful science take place and accurate and helpful crime reconstructions to be achieved

Effect of the association of three drugs in the treatment of congestive heart failure in dogs with mitral myxomatosis

The authors studied the response in dogs with varying degrees of congestive heart failure due to\nmyxomatous valve disease the simultaneous administration of three drugs: spironolactone, benazepril\nand magnesium gluconate.\nThe studied patients (25) hadn?t received medication at the time of the first evaluation and that\nassociation was administered at dose of 2 mg / kg; 0.25 mg / kg and 7.5 mg / kg respectively every\n24 hours for a period of four months.\nThe data obtained were processed statistically by performing test for normality ( Shapiro-Wilks test\nand Wilcoxon) and inference based on two-sample (?t? for paired samples)\nThe results showed an overall clinical improvement, verified by history and clinical evaluation,\nimprovement in ECG parameters and significant differences in serum urea and creatinine, in\nthe regurgitate volume and systolic and diastolic blood pressure. No changes in two-dimensional\nechocardiographic parameters studied were observed.Fil: Buzzano, O. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela. Unidad de Cardiología; ArgentinaFil: Graziano, A. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela. Unidad de Cardiología; ArgentinaFil: Barrios, J. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela. Unidad de Cardiología; ArgentinaFil: Lightowler, C. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela. Unidad de Cardiología; ArgentinaLos autores estudiaron la respuesta de perros con distintos grados de insuficiencia cardiaca congestiva\nmotivada por mixomatosis de la válvula mitral a la administración simultánea de tres drogas:\nespironolactona, benazepril y gluconato de magnesio.\nLos pacientes estudiados (25) no habían recibido ninguna medicación a la fecha del inicio del\nestudio y la mencionada asociación se administró en dosis de 2 mg/kg; 0,25mg/kg y 7,5mg/kg\nrespectivamente, cada 24 horas, por un período de cuatro meses.\nLos datos obtenidos fueron procesados estadísticamente realizando prueba de normalidad ShapiroWilks,\ntest de Wilcoxon e inferencia basada en dos muestras (?t? para muestras apareadas).\nLos resultados obtenidos mostraron una mejoría clínica general, verificada por anamnesis y evaluación\nclínica, una mejoría en los parámetros electrocardiográficos y diferencias significativas en los valores\nde urea y creatinina, en el volumen regurgitante y en la tensión arterial sistólica y diastólica. No se\nobservaron modificaciones de los parámetros ecocardiográficos bidimensionales estudiados

Flujos atrioventriculares normales evaluados por la técnica Doppler espectral en caninos

Los autores realizaron un estudio de las posiciones más adecuadas para estudiar los flujos transmitral y transtricuspídeo por medio de Doppler espectral pulsado en caninos normales y determinar los valores medios de los siguientes parámetros: velocidad pico, velocidad media, gradiente pico de presión, gradiente medio de presión, integral tiempo–velocidad y relación entre ondas E y A. Las mejores posiciones para la obtención de valores del flujo mitral y tricuspídeo fueron la imagen apical de cinco cámaras captada desde la ventana paraesternal izquierda para la primera y la oblicua del tracto de entrada ventricular derecho en la misma ventana para la segunda

Early Clinical and Subclinical Visual Evoked Potential and Humphrey's Visual Field Defects in Cryptococcal Meningitis.

Cryptococcal induced visual loss is a devastating complication in survivors of cryptococcal meningitis (CM). Early detection is paramount in prevention and treatment. Subclinical optic nerve dysfunction in CM has not hitherto been investigated by electrophysiological means. We undertook a prospective study on 90 HIV sero-positive patients with culture confirmed CM. Seventy-four patients underwent visual evoked potential (VEP) testing and 47 patients underwent Humphrey's visual field (HVF) testing. Decreased best corrected visual acuity (BCVA) was detected in 46.5% of patients. VEP was abnormal in 51/74 (68.9%) right eyes and 50/74 (67.6%) left eyes. VEP P100 latency was the main abnormality with mean latency values of 118.9 (±16.5) ms and 119.8 (±15.7) ms for the right and left eyes respectively, mildly prolonged when compared to our laboratory references of 104 (±10) ms (p<0.001). Subclinical VEP abnormality was detected in 56.5% of normal eyes and constituted mostly latency abnormality. VEP amplitude was also significantly reduced in this cohort but minimally so in the visually unimpaired. HVF was abnormal in 36/47 (76.6%) right eyes and 32/45 (71.1%) left eyes. The predominant field defect was peripheral constriction with an enlarged blind spot suggesting the greater impact by raised intracranial pressure over that of optic neuritis. Whether this was due to papilloedema or a compartment syndrome is open to further investigation. Subclinical HVF abnormalities were minimal and therefore a poor screening test for early optic nerve dysfunction. However, early optic nerve dysfunction can be detected by testing of VEP P100 latency, which may precede the onset of visual loss in CM

Reexamining evidence-based practice in community corrections: beyond 'a confined view' of what works

This article aims to reexamine the development and scope of evidence-based practice (EBP) in community corrections by exploring three sets of issues. Firstly, we examine the relationships between the contested purposes of community supervision and their relationships to questions of evidence. Secondly, we explore the range of forms of evidence that might inform the pursuit of one purpose of supervision—the rehabilitation of offenders—making the case for a fuller engagement with “desistance” research in supporting this process. Thirdly, we examine who can and should be involved in conversations about EBP, arguing that both ex/offenders’ and practitioners’ voices need to be respected and heard in this debate

Glycaemic Index, Glycaemic Load and dietary fibre characteristics of two commercially available fruit smoothies

In light of the updated Eatwell Guide and the corresponding change in the consumption of fruit smoothies, the aim of this study was to measure the glycaemic index and load of two commercial fruit smoothies and to investigate the retention of dietary fibre following production. In vitro analysis was performed to identify fibre material (cellulose and pectins) using calcofluor staining and immunocytochemical labelling. A repeated measures crossover study was conducted (n 10) to determine the Glycaemic Index (GI) and Glycaemic Load (GL) of the smoothies. Results showed that dietary fibre was still present in the smoothies after processing (16.9-17.5% cellular material by dry weight). The GI was low for both smoothies (39 and 36), whereas the GL was medium and borderline-low, respectively (11.4 and 9.7). The retention of fibre in these smoothies may have a potential positive effect on glycaemic response and may contribute to daily fibre requirements

Treatment of Cryptococcal Meningitis in KwaZulu-Natal, South Africa

BACKGROUND: Cryptococcal meningitis (CM) remains a leading cause of death for HIV-infected individuals in sub-Saharan Africa. Improved treatment strategies are needed if individuals are to benefit from the increasing availability of antiretroviral therapy. We investigated the factors associated with mortality in routine care in KwaZulu-Natal, South Africa. METHODOLOGY/PRINCIPAL FINDINGS: A prospective year long, single-center, consecutive case series of individuals diagnosed with cryptococcal meningitis 190 patients were diagnosed with culture positive cryptococcal meningitis, of whom 186 were included in the study. 52/186 (28.0%) patients died within 14 days of diagnosis and 60/186 (32.3%) had died by day 28. In multivariable cox regression analysis, focal neurology (aHR 11 95%C.I. 3.08-39.3, P<0.001), diastolic blood pressure<60 mmHg (aHR 2.37 95%C.I. 1.11-5.04, P=0.025), concurrent treatment for tuberculosis (aHR 2.11 95%C.I. 1.02-4.35, P=0.044) and use of fluconazole monotherapy (aHR 3.69 95% C.I. 1.74-7.85, P<0.001) were associated with increased mortality at 14 and 28 days. CONCLUSIONS: Even in a setting where amphotericin B is available, mortality from cryptococcal meningitis in this setting is high, particularly in the immediate period after diagnosis. This highlights the still unmet need not only for earlier diagnosis of HIV and timely access to treatment of opportunistic infections, but for better treatment strategies of cryptococcal meningitis

Development and validation of MIX: comprehensive free software for meta-analysis of causal research data

BACKGROUND: Meta-analysis has become a well-known method for synthesis of quantitative data from previously conducted research in applied health sciences. So far, meta-analysis has been particularly useful in evaluating and comparing therapies and in assessing causes of disease. Consequently, the number of software packages that can perform meta-analysis has increased over the years. Unfortunately, it can take a substantial amount of time to get acquainted with some of these programs and most contain little or no interactive educational material. We set out to create and validate an easy-to-use and comprehensive meta-analysis package that would be simple enough programming-wise to remain available as a free download. We specifically aimed at students and researchers who are new to meta-analysis, with important parts of the development oriented towards creating internal interactive tutoring tools and designing features that would facilitate usage of the software as a companion to existing books on meta-analysis. RESULTS: We took an unconventional approach and created a program that uses Excel as a calculation and programming platform. The main programming language was Visual Basic, as implemented in Visual Basic 6 and Visual Basic for Applications in Excel 2000 and higher. The development took approximately two years and resulted in the 'MIX' program, which can be downloaded from the program's website free of charge. Next, we set out to validate the MIX output with two major software packages as reference standards, namely STATA (metan, metabias, and metatrim) and Comprehensive Meta-Analysis Version 2. Eight meta-analyses that had been published in major journals were used as data sources. All numerical and graphical results from analyses with MIX were identical to their counterparts in STATA and CMA. The MIX program distinguishes itself from most other programs by the extensive graphical output, the click-and-go (Excel) interface, and the educational features. CONCLUSION: The MIX program is a valid tool for performing meta-analysis and may be particularly useful in educational environments. It can be downloaded free of charge via or

Noninvasive positive pressure ventilation for acute respiratory failure in children: a concise review

Noninvasive positive pressure ventilation (NPPV) refers to the delivery of mechanical respiratory support without the use of endotracheal intubation (ETI). The present review focused on the effectiveness of NPPV in children > 1 month of age with acute respiratory failure (ARF) due to different conditions. ARF is the most common cause of cardiac arrest in children. Therefore, prompt recognition and treatment of pediatric patients with pending respiratory failure can be lifesaving. Mechanical respiratory support is a critical intervention in many cases of ARF. In recent years, NPPV has been proposed as a valuable alternative to invasive mechanical ventilation (IMV) in this acute setting. Recent physiological studies have demonstrated beneficial effects of NPPV in children with ARF. Several pediatric clinical studies, the majority of which were noncontrolled or case series and of small size, have suggested the effectiveness of NPPV in the treatment of ARF due to acute airway (upper or lower) obstruction or certain primary parenchymal lung disease, and in specific circumstances, such as postoperative or postextubation ARF, immunocompromised patients with ARF, or as a means to facilitate extubation. NPPV was well tolerated with rare major complications and was associated with improved gas exchange, decreased work of breathing, and ETI avoidance in 22-100% of patients. High FiO2 needs or high PaCO2 level on admission or within the first hours after starting NPPV appeared to be the best independent predictive factors for the NPPV failure in children with ARF. However, many important issues, such as the identification of the patient, the right time for NPPV application, and the appropriate setting, are still lacking. Further randomized, controlled trials that address these issues in children with ARF are recommended