50 research outputs found
Diagnosis and Pharmacotherapy of Stable Chronic Obstructive Pulmonary Disease : The Finnish Guidelines
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Molecular evidence for a recent demographic expansion in the puma (Puma concolor) (Mammalia, Felidae)
Full text linkCoordinatively Unsaturated T-Shaped Platinum(II) Complexes Stabilized by Small N-Heterocyclic Carbene Ligands. Synthesis and Cyclometalation
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Treatment Choice With Trial Data: Statistical Decision Theory Should Supplant Hypothesis Testing
No full textTransaldolase genes from the cyanobacteria Anabaena variabilis and Synechocystis sp. PCC 6803: comparison with other eubacterial and eukaryotic homologues
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Optimization Based Design of Synthetic Oscillators from Standard Biological Parts
No full text13 pages.-- 12th International Conference on Computational Methods in Systems Biology, CMSB 2014, Manchester, UK, November 17-19, 2014We consider the problem of optimal design of synthetic biological oscillators. Our aim is, given a set of standard biological parts and some pre-specified performance requirements, to automatically find the circuit configuration and its tuning so that self-sustained oscillations meeting the requirements are produced. To solve this design problem, we present a methodology based on mixed-integer nonlinear optimization. This method also takes into account the possibility of including more than one design objective and of handling both deterministic and stochastic descriptions of the dynamics. Further, it is capable of handling significant levels of circuit complexity. We illustrate the performance of this method with several challenging case studiesN
