52 research outputs found
Getting Acquainted with Kant
My question here concerns whether Kant claims that experience has
nonconceptual content, or whether, on his view, experience is
essentially conceptual. However there is a sense in which this debate
concerning the content of intuition is ill-conceived. Part of this has
to do with the terms in which the debate is set, and part to do with
confusion over the connection between Kant’s own views and contemporary
concerns in epistemology and the philosophy of mind. However, I think
much of the substance of the debate concerning Kant’s views on the
content of experience can be salvaged by reframing it in terms of a
debate about the dependence relations, if any, that exist between
different cognitive capacities. Below, in Section 2, I clarify the
notion of ‘content’ I take to be at stake in the interpretive debate.
Section 3 presents reasons for thinking that intuition cannot have
content in the relevant sense. I then argue, in Section 4, that the
debate be reframed in terms of dependence. We should distinguish between
Intellectualism, according to which all objective representation
(understood in a particular way) depends on acts of synthesis by the
intellect, and Sensibilism, according to which at least some forms of
objective representation are independent of any such acts (or the
capacity for such acts). Finally, in Section 5, I further elucidate the
cognitive role of intuition. I articulate a challenge which Kant
understands alethic modal considerations to present for achieving
cognition, and argue that a version of Sensibilism that construes
intuition as a form of acquaintance is better positioned to answer this
challenge than Intellectualism
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.</p
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities
Infrared Luminescence in Er and Er+O Implanted 6H SiC
Photoluminescence in the neighbourhood of 1.54 μm due to the I -I intra-4f-shell transitions of Er ions in 6H SiC is studied. Effects of oxygen coimplantation is also investigated. No difference in the photoluminescence spectra of Er only and Er+O implanted SiC was found. It is concluded that the emission around 1.54 μm in SiC:Er originates from erbium-oxygen complexes, which are formed as a result of thermal annealing
Pre-operative evaluation of patients undergoing knee articular cartilage repair: MRI 3D thickness maps derived from a validated, automated segmentation platform - initial results
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