183 research outputs found
Liver microwave ablation:a systematic review of various FDA-approved systems
ObjectivesThe aim of the present study is to analyze preclinical and clinical data on the performance of the currently US Food and Drug Administration (FDA)-approved microwave ablation (MWA) systems.MethodsA review of the literature, published between January 1, 2005, and December 31, 2016, on seven FDA-approved MWA systems, was conducted. Ratio of ablation zone volume to applied energy R(AZ:E) and sphericity indices were calculated for ex vivo and in vivo experiments.ResultsThirty-four studies with ex vivo, in vivo, and clinical data were summarized. In total, 14 studies reporting data on ablation zone volume and applied energy were included for comparison R(AZ:E). A significant correlation between volume and energy was found for the ex vivo experiments (r=0.85,
The influence of the da Vinci surgical robot on electromagnetic tracking in a clinical environment
Robot-assisted surgery is increasingly used in surgery for cancer. Reduced overview and loss of anatomical orientation are challenges that might be solved with image-guided surgical navigation using electromagnetic tracking (EMT). However, the robot’s presence may distort the electromagnetic field, affecting EMT accuracy. The aim of this study was to evaluate the robot’s influence on EMT accuracy. For this purpose, two different electromagnetic field generators were used inside a clinical surgical environment: a table top field generator (TTFG) and a planar field generator (PFG). The position and orientation of sensors within the electromagnetic field were measured using an accurate in-house developed 3D board. Baseline accuracy was measured without the robot, followed by stepwise introduction of potential distortion sources (robot and robotic instruments). The absolute accuracy was determined within the entire 3D board and in the clinical working volume. For the baseline setup, median errors in the entire tracking volume within the 3D board were 0.9 mm and 0.3° (TTFG), and 1.1 mm and 0.4° (PFG). Adding the robot and instruments did not affect the TTFG’s position accuracy (p = 0.60), while the PFG’s accuracies decreased to 1.5 mm and 0.7° (p < 0.001). For both field generators, when adding robot and instruments, accuracies inside the clinical working volume were higher compared to the entire tracking 3D board volume, 0.7 mm and 0.3° (TTFG), and 1.1 mm and 0.7° (PFG). Introduction of a surgical robot and robotic instruments shows limited distortion of the EMT field, allowing sufficient accuracy for surgical navigation in robotic procedures.</p
Conceptualizing the Circular Economy (Revisited):An Analysis of 221 Definitions
In the past decade, use of the circular economy (CE) concept by scholars and practitioners has grown steadily. In a 2017 article, Kirchherr et al. found that the CE concept is interpreted and implemented in a variety of ways. While multiple interpretations of CE can enrich scholarly perspectives, differentiation and fragmentation can also impede consolidation of the concept. Some scholarship has discussed these trends in context-specific cases, but no large-scale, systematic study has analysed whether such consolidation has taken place across the field. This article fills this gap by analysing 221 recent CE definitions, making several notable findings. First, the concept has seen both consolidation and differentiation in the past five years. Second, definitional trends are emerging that potentially have more meaning for scholarship than for practice. Third, scholars increasingly recommend a fundamental systemic shift to enable CE, particularly within supply chains. Fourth, sustainable development is frequently considered the principal aim of CE, but questions linger about whether CE can mutually support environmental sustainability and economic development. Finally, recent studies argue that CE transition relies on a broad alliance of stakeholders, including producers, consumers, policymakers, and scholars. This study contributes an updated systematic analysis of CE definitions and conceptualizations that serves as an empirical snapshot of current scholarly thinking. It thereby provides a basis for further research on whether conceptual consolidation is needed and how it can be facilitated for practical purposes.</p
Testing refinements by refining tests
One of the potential benefits of formal methods is that they offer the possibility of reducing the costs of testing. A specification acts as both the benchmark against which any implementation is tested, and also as the means by which tests are generated. There has therefore been interest in developing test generation techniques from formal specifications, and a number of different methods have been derived for state based languages such as Z, B and VDM. However, in addition to deriving tests from a formal specification, we might wish to refine the specification further before its implementation. The purpose of this paper is to explore the relationship between testing and refinement. As our model for test generation we use a DNF partition analysis for operations written in Z, which produces a number of disjoint test cases for each operation. In this paper we discuss how the partition analysis of an operation alters upon refinement, and we develop techniques that allow us to refine abstract tests in order to generate test cases for a refinement. To do so we use (and extend existing) methods for calculating the weakest data refinement of a specification
Assessing Acceptance of Assistive Social Agent Technology by Older Adults: the Almere Model
relating conversational expressiveness to social presence and accpetance of an assistive social robot
Exploring the relationship between social presence, conversational expressiveness, and robot acceptance, we set up an experiment with a robot in an eldercare institution, comparing a more and less social condition. Participants showed more expressiveness with a more social agent and a higher score on expressiveness correlated with higher scores on social presence. Furthermore, scores on social presence correlated with the scores on the intention to use the system in the near future. However, we found no correlation between conversational expressiveness and robot acceptance
Respiratory level tracking with visual biofeedback for consistent breath-hold level with potential application in image-guided interventions
Background: To present and evaluate a new respiratory level biofeedback system that aids the patient to return to a consistent breath-hold level with potential application in image-guided interventions. Methods: The study was approved by the local ethics committee and written informed consent was waived. Respiratory motion was recorded in eight healthy volunteers in the supine and prone positions, using a depth camera that measures the mean distance to thorax, abdomen and back. Volunteers were provided with real-time visual biofeedback on a screen, as a ball moving up and down with respiratory motion. For validation purposes, a conversion factor from mean distance (in mm) to relative lung volume (in mL) was determined using spirometry. Subsequently, without spirometry, volunteers were given breathing instructions and were asked to return to their initial breath-hold level at expiration ten times, in both positions, with and without visual biofeedback. For both positions, the median and interquartile range (IQR) of the absolute error in lung volume from initial breath-hold were determined with and without biofeedback and compared using Wilcoxon signed rank tests. Results: Without visual biofeedback, the median difference from initial breath-hold was 124.6 mL (IQR 55.7-259.7 mL) for the supine position and 156.3 mL (IQR 90.9-334.7 mL) for the prone position. With the biofeedback, the difference was significantly decreased to 32.7 mL (IQR 12.8-59.6 mL) (p < 0.001) and 22.3 mL (IQR 7.7-47.0 mL) (p < 0.001), respectively. Conclusions: The use of a depth camera to provide visual biofeedback increased the reproducibility of breath-hold expiration level in healthy volunteers, with a potential to eliminate targeting errors caused by respiratory movement during lung image-guided procedures
The relationship between applied energy and ablation zone volume in patients with hepatocellular carcinoma and colorectal liver metastasis
To study the ratio of ablation zone volume to applied energy in computed tomography (CT)-guided radiofrequency ablation (RFA) and microwave ablation (MWA) in patients with hepatocellular carcinoma (HCC) in a cirrhotic liver and in patients with colorectal liver metastasis (CRLM). In total, 90 liver tumors, 45 HCCs in a cirrhotic liver and 45 CRLMs were treated with RFA or with one of two MWA devices (MWA_A and MWA_B), resulting in 15 procedures for each tumor type, per device. Device settings were recorded and the applied energy was calculated. Ablation volumes were segmented on the contrast-enhanced CT scans obtained 1 week after the procedure. The ratio of ablation zone volume in milliliters to applied energy in kilojoules was determined for each procedure and compared between HCC (R (HCC)) and CRLM (R (CRLM)), stratified according to ablation device. With RFA, R (HCC) and R (CRLM) were 0.22 mL/kJ (0.14-0.45 mL/kJ) and 0.15 mL/kJ (0.14-0.22 mL/kJ; p = 0.110), respectively. With MWA_A, R (HCC) was 0.81 (0.61-1.07 mL/kJ) and R (CRLM) was 0.43 (0.35-0.61 mL/kJ; p = 0.001). With MWA_B, R (HCC) was 0.67 (0.41-0.85 mL/kJ) and R (CRLM) was 0.43 (0.35-0.61 mL/kJ; p = 0.040). With RFA, there was no significant difference in energy deposition ratio between tumor types. With both MWA devices, the ratios were higher for HCCs. Tailoring microwave ablation device protocols to tumor type might prevent incomplete ablations. aEuro cent HCCs and CRLMs respond differently to microwave ablation aEuro cent For MWA, CRLMs required more energy to achieve a similar ablation volume aEuro cent Tailoring ablation protocols to tumor type might prevent incomplete ablations
Test Model Coverage Analysis under Uncertainty
In model-based testing (MBT) we may have to deal with a non-deterministic
model, e.g. because abstraction was applied, or because the software under test
itself is non-deterministic. The same test case may then trigger multiple
possible execution paths, depending on some internal decisions made by the
software. Consequently, performing precise test analyses, e.g. to calculate the
test coverage, are not possible. This can be mitigated if developers can
annotate the model with estimated probabilities for taking each transition. A
probabilistic model checking algorithm can subsequently be used to do simple
probabilistic coverage analysis. However, in practice developers often want to
know what the achieved aggregate coverage, which unfortunately cannot be
re-expressed as a standard model checking problem. This paper presents an
extension to allow efficient calculation of probabilistic aggregate coverage,
and moreover also in combination with k-wise coverage
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