Developing Interactive Curricular Elements with Teams of Faculty, Staff and Students

Students are continually searching for new resources to augment their learning. Online resources have become highly favored, especially by the millennial age group, for convenience, self-paced content, and versatility across learning styles. It has been reported that e-learning platforms are as effective as traditional face-to-face instruction, but may be best utilized when used as an adjunctive resource for teaching psychomotor skills.1,2 In a study about student confidence, results showed an increase in self-efficacy following the use of online learning materials.3 Blended learning, the next generation of web-based education, mixes advances in technology with creative faculty to fuse effective delivery methods that promote student engagement and learning. Re-designing all or portions of a course with a fresh prospective can re-energize faculty and render content more engaging for the learner but development can be hampered by limited time and resources. Our academic health science center launched a strategic initiative in 2013 for interprofessional student and faculty teams to build interactive e-learning modules. This presentation will focus on the significant role of medical and allied health science students in the development of interactive curricular elements, which can save faculty time and resources while enhancing student learning. Through this program, a large interprofessional network of collaborators with varying skill sets was created. The network includes nearly 100 students and faculty members from medical and allied health professions that have created over 50 e-learning projects. The greatest benefits of engaging student-faculty teams as e-learning developers have been the trust and cohesion, resource sharing and brokering of information consistent with the social capital theory. In addition, the high quality of e-modules resulting from the creative use of media-rich content in student designs increased peer engagement. With students as e-learning collaborators, faculty as content experts, and instructional design expertise we increased the production of curricular-based e-learning modules within a budget-friendly model while reducing faculty time required for development. More importantly, many additional modules have been created by teams outside of the formal institutional mechanism, suggesting the widespread adoption of this teaching modality in an expanding network. Regardless of educational trends, faculty who implement a novel learning tool should be aware of the learner’s cognitive load, or working memory, which has a limited capacity. Each module is evaluated using a checklist to examine accessibility and educational design. There are content development strategies using visual and auditory channels to maximize learner efficiency and minimize distractions for long-term memory development.4 The presenters will share an overview of this initiative and practical experience. We will a) describe the resultant network structure and composition of faculty, students and staff involved; b) provide a step-by-step timeline of how the e-learning modules went from a sketch and brainstormed idea to a tangible and useful product and the important role of instructional designers and an interprofessional peer-faculty team, c) share resources used for creation, and d) demonstrate exemplars on topics such as joint examination, the cardiopulmonary system, International Classification of Functioning, scanning a hospital room, and reviewing a medical chart

Prevention of Glaucoma-Induced Retinal Ganglion Cell Loss Using Alpha7 nAChR Agonists

In this study, the neuroprotective effect of various nicotinic alpha7 acetylcholine receptor agonists in an in-vivo model of glaucoma using adult Long Evans rats was analyzed. Glaucoma-like conditions were induced in the eyes of Long Evans rats after injection of hypertonic saline into episcleral veins to create scar tissue and increase the animal’s intraocular pressure. This procedure produced significant loss of retinal ganglion cells within one month and was associated with an increase of intraocular pressure. Using this model system, various alpha7 nicotinic acetylcholine receptor (a7 nAChR) agonists were applied at different doses as eye drops to the right eye of adult Long Evans rats while the left eye was left as an internal control. The a7 nAChR agonists used in this study prevented loss of RGCs in a dose dependent manner after the procedure to induce glaucoma-like conditions. PHA-543613 and PNU- 282987 provided the largest degree of RGC survival after inducing glaucomalike conditions, followed by nicotine, SEN 12333, tropisetron, 3-Bromocytisine and DMAB. To provide evidence that neuroprotection of RGCs was mediated through activation of a7 nAChR, in some studies different concentrations of the a7 nAChR antagonist, MLA, was intravitreally injected into experimentally treated eyes before initiation of eye drops and the procedure to induce glaucoma-like conditions. In the presence of MLA, RGC neuroprotection was blocked. Results from these studies suggest that selective a7 nAChR agonists may be used in future therapeutic treatments for glaucoma or other CNS diseases associated with a7 nAChRs

Self-DUal SU(3) Chern-Simons Higgs Systems

We explore self-dual Chern-Simons Higgs systems with the local $SU(3)$ and global $U(1)$ symmetries where the matter field lies in the adjoint representation. We show that there are three degenerate vacua of different symmetries and study the unbroken symmetry and particle spectrum in each vacuum. We classify the self-dual configurations into three types and study their properties.Comment: Columbia Preprint CU-TP-635, 19 page

Unilateral elongated styloid process: a case report

An unusual case of a unilaterally elongated styloid process with a length of 5.8 cm was found on a dry skull of a male cadaver. During his life the subject was complaining for reported ipsilateral otalgia presumably due to nerve compression from the elongated styloid process. The symptomatology appeared by such an anatomical variant as well as relative literature is discussed in this paper

Understanding renal posttransplantation anemia in the pediatric population

Advances in renal transplantation management have proven to be beneficial in improving graft and patient survival. One of the properties of a well-functioning renal allograft is the secretion of adequate amounts of the hormone erythropoietin to stimulate erythropoiesis. Posttransplantation anemia (PTA) may occur at any point in time following transplantation, and the cause is multifactoral. Much of our understanding of PTA is based on studies of adult transplant recipients. The limited number of studies that have been reported on pediatric renal transplant patients appear to indicate that PTA is prevalent in this patient population. Erythropoietin deficiency or resistance is commonly associated with iron deficiency. An understanding of the risk factors, pathophysiology and management of PTA in the pediatric renal transplant population may provide guidelines for clinicians and researchers in the pursuit of larger prospective randomized control studies aimed at improving our limited knowledge of PTA. Recognition of PTA through regular screening and evaluation of the multiple factors that may contribute to its development are recommended after transplantation

Regulatory Effect of Connexin 43 on Basal Ca2+ Signaling in Rat Ventricular Myocytes

Background: It has been found that gap junction-associated intracellular Ca 2+ [Ca 2+]i disturbance contributes to the arrhythmogenesis and hyperconstriction in diseased heart. However, whether functional gaps are also involved in the regulation of normal Ca 2+ signaling, in particular the basal [Ca 2+] i activities, is unclear. Methods and Results: Global and local Ca 2+ signaling and gap permeability were monitored in cultured neonatal rat ventricular myocytes (NRVMs) and freshly isolated mouse ventricular myocytes by Fluo4/AM and Lucifer yellow (LY), respectively. The results showed that inhibition of gap communication by heptanol, Gap 27 and flufenamic acid or interference of connexin 43 (Cx43) with siRNA led to a significant suppression of LY uptake and, importantly, attenuations of global Ca 2+ transients and local Ca 2+ sparks in monolayer NRVMs and Ca 2+ sparks in adult ventricular myocytes. In contrast, overexpression of rat-Cx43 in NRVMs induced enhancements in the above measurements, and so did in HEK293 cells expressing rat Cx43. Additionally, membrane-permeable inositol 1,4,5-trisphosphate (IP3 butyryloxymethyl ester) and phenylephrine, an agonist of adrenergic receptor, could relieve the inhibited Ca 2+ signal and LY uptake by gap uncouplers, whereas blockade of IP 3 receptor with xestospongin C or 2-aminoethoxydiphenylborate mimicked the effects of gap inhibitors. More importantly, all these gap-associated effects on Ca 2+ signaling were also found in single NRVMs that only have hemichannels instead of gap junctions. Further immunostaining/immunoblotting single myocytes with antibod

ICAR: endoscopic skull‐base surgery

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