Epigenetics and immunometabolism in diabetes and aging

Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets. Recent Advances: The link between immunity and metabolism is bi-directional and includes the role of inflammation in the pathogenesis of metabolic disorders such as T2D, obesity, metabolic syndrome and hypertension as well as the role of metabolic factors in regulation of immune cell functions. Low-grade inflammation, oxidative stress, balance between superoxide and nitric oxide, and the infiltration of macrophages, T cells, B cells in insulin-sensitive tissues, leads to metabolic impairment and accelerated ageing. Critical Issues: Inflammatory infiltrate and altered immune cell phenotype precede development of metabolic disorders. Inflammatory changes are tightly linked to alterations in metabolic status and energy expenditure and are controlled by epigenetic mechanisms. Future directions: A better comprehension of these mechanistic insights is of utmost importance to identify novel molecular targets. Here, we describe a complex scenario of epigenetic changes and immunometabolism linking to diabetes and aging-associated vascular disease

First principles theory of the EPR g-tensor in solids: defects in quartz

A theory for the reliable prediction of the EPR g-tensor for paramagnetic defects in solids is presented. It is based on density functional theory and on the gauge including projector augmented wave (GIPAW) approach to the calculation of all-electron magnetic response. The method is validated by comparison with existing quantum chemical and experimental data for a selection of diatomic radicals. We thenperform the first prediction of EPR ${\rm g}$-tensors in the solid state and find the results to be in excellent agreement with experiment for the $E'_1$ and substitutional P defect centers in quartz.Comment: 5 pages, 4 table

Epigenetics and immunometabolism in diabetes and aging

Significance: A strong relationship between hyperglycemia, impaired insulin pathway, and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets. Recent Advances: The link between immunity and metabolism is bidirectional and includes the role of inflammation in the pathogenesis of metabolic disorders such as T2D, obesity, metabolic syndrome, and hypertension and the role of metabolic factors in regulation of immune cell functions. Low-grade inflammation, oxidative stress, balance between superoxide and nitric oxide, and the infiltration of macrophages, T cells, and B cells in insulin-sensitive tissues lead to metabolic impairment and accelerated aging. Critical Issues: Inflammatory infiltrate and altered immune cell phenotype precede development of metabolic disorders. Inflammatory changes are tightly linked to alterations in metabolic status and energy expenditure and are controlled by epigenetic mechanisms. Future Directions: A better comprehension of these mechanistic insights is of utmost importance to identify novel molecular targets. In this study, we describe a complex scenario of epigenetic changes and immunometabolism linking to diabetes and aging-associated vascular disease. © Tomasz J

On chemical equilibrium in nuclear collisions

The data on average hadron multiplicities in central A+A collisions measured at CERN SPS are analysed with the ideal hadron gas model. It is shown that the full chemical equilibrium version of the model fails to describe the experimental results. The agreement of the data with the off-equilibrium version allowing for partial strangeness saturation is significantly better. The freeze-out temperature of about 180 MeV seems to be independent of the system size (from S+S to Pb+Pb) and in agreement with that extracted in e+e-, pp and p{\bar p} collisions. The strangeness suppression is discussed at both hadron and valence quark level. It is found that the hadronic strangeness saturation factor gamma_S increases from about 0.45 for pp interactions to about 0.7 for central A+A collisions with no significant change from S+S to Pb+Pb collisions. The quark strangeness suppression factor lambda_S is found to be about 0.2 for elementary collisions and about 0.4 for heavy ion collisions independently of collision energy and type of colliding syste

Critical and Multicritical Semi-Random (1+d)-Dimensional Lattices and Hard Objects in d Dimensions

We investigate models of (1+d)-D Lorentzian semi-random lattices with one random (space-like) direction and d regular (time-like) ones. We prove a general inversion formula expressing the partition function of these models as the inverse of that of hard objects in d dimensions. This allows for an exact solution of a variety of new models including critical and multicritical generalized (1+1)-D Lorentzian surfaces, with fractal dimensions $d_F=k+1$, k=1,2,3,..., as well as a new model of (1+2)-D critical tetrahedral complexes, with fractal dimension $d_F=12/5$. Critical exponents and universal scaling functions follow from this solution. We finally establish a general connection between (1+d)-D Lorentzian lattices and directed-site lattice animals in (1+d) dimensions.Comment: 44 pages, 15 figures, tex, harvmac, epsf, references adde