Economía, arbitristmo y política en la Monarquía hispánica a fines del siglo XVI

Mediante la referencia a numerosos tratadistas de fines del siglo XVI y comienzos del siglo XVII, el autor expone la imposibilidad de realizar una aproximación diferenciada al pensamiento teológico, político o económico coetáneo. A partir de la muerte de Felipe II, con la clara conciencia de vivir un período de crisis, estos autore3 plantearán desde esa perpectiva plural las causas de las alteraciones en la Monarquía Hispánica y los remedios orientados a lograr la restauración, no el cambio, del orden y los valores sociales en declive.A partir de la referencia a nombrosos tractadistes de finals del segle XVI i inicis del segle XVII, I'autor exposa la impossibilitat de portar a teme una aproximació diferenciada sobre el pensament teologic, polític o economic coetani. Arran de la mort de Felip II, amb la clara consciencia de viure un període de crisi, aquests autors plantejaran des d'aquesta perspectiva plural les causes de les mutacions a la Monarquia Hisphica i els remeis orientats a assolir la restauració, no el canvi, de I'ordre i els valors socials en declivi.Fortea Perez uses the testimonies of many late 16th century and early 17th century authors to state the impossibility of a discerning approach to contemporaneous theological, political or economical ideas. From this plural standpoint and with a neat conscience of being in the middle of a critical period, after the death of Philip II, those authors uttered the causes of the alterations in the Spanish Monarchy as well as the counteractions needed to restore, not to change, social order and values now in recession

An insight into the separation of 1, 2-propanediol, ethylene glycol, acetol and glycerol from an aqueous solution by adsorption on activated carbon

Glycerol conversion processes such as aqueous phase reforming and hydrogenolysis generate value-added compounds highly diluted in water. Because distillation is a high energy demand separation step, adsorption could be an attractive alternative to recover these chemicals. Adsorption isotherms of 1, 2-propanediol, acetol, ethylene glycol and glycerol onto activated carbon were determined by batch adsorption experiments. These isotherms were fitted slightly better to the Freundlich equation than to the Langmuir equation. Acetol is the compound with the highest adsorption at concentrations smaller than 1 M. Properties of the adsorbate such as the -OH group number, chain length, molecular size and dipole moment, besides characteristics of the adsorbent such as the surface area, oxygen and ash content, are considered to explain the observed results. Moreover, adsorption experiments were performed with mixtures of compounds and it was determined that the molar amount adsorbed is less than predicted from the adsorption isotherms of the individual compounds treated separately. In addition, the influence of the activated carbon thermal pretreatment temperature on the adsorption capacity has been studied, the optimum being 800¿C. An analysis of the influence of the activated carbon characteristics showed that the most important parameters are the total pore volume and the ash content. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Patología escapulo-clavicular en un sujeto de Morella

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Patología de ligamentos en la meseta tibial

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

The role of membrane-bound metal ions in toxicity of a human cancer cell-active pore-forming toxin Cry41Aa from Bacillus thuringiensis

Bacillus thuringiensis crystal (Cry) proteins, used for decades as insecticidal toxins, are well known to be toxic to certain insects, but not to mammals. A novel group of Cry toxins called parasporins possess a strong cytocidal activity against some human cancer cells. Cry41Aa, or parasporin3, closely resembles commercially used insecticidal toxins and yet is toxic to the human hepatic cancer cell line HepG2, disrupting membranes of susceptible cells, similar to its insecticidal counterparts. In this study, we explore the protective effect that the common divalent metal chelator EGTA exerts on Cry41Aa's activity on HepG2 cells. Our results indicate that rather than interfering with a signalling pathway as a result of chelating cations in the medium, the chelator prevented the toxin's interaction with the membrane, and thus the subsequent steps of membrane damage and p38 phosphorylation, by removing cations bound to plasma membrane components. BAPTA and DTPA also inhibited Cry41Aa toxicity but at higher concentrations. We also show for the first time that Cry41Aa induces pore formation in planar lipid bilayers. This activity is not altered by EGTA, consistent with a biological context of chelation. Salt supplementation assays identified Ca2+, Mn2+ and Zn2+ as being able to reinstate Cry41Aa activity. Our data suggest the existence of one or more metal cation-dependent receptors in the Cry41Aa mechanism of action

Miositis calcificante: estudio antropométrico y paleopatológico de tres casos

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Tendinopatía del radio: estudio anatómico y paleopatológico

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200