Strong resonant tunneling, level repulsion and spectral type for one-dimensional adiabatic quasi-periodic Schr\"{o}dinger operators

In this paper, we consider one dimensional adiabatic quasi-periodic Schr\"{o}dinger operators in the regime of strong resonant tunneling. We show the emergence of a level repulsion phenomenon which is seen to be very naturally related to the local spectral type of the operator: the more singular the spectrum, the weaker the repulsion

Evaluation of sympathoadrenal system and adrenal cortex functional activity among children in the age and sexaspects

© 2016, International Journal of Pharmacy and Technology. All rights reserved.The study of relationship between sympathetic-adrenal and pituitary-adrenal systems at the level of the whole organism in ontogenesis is a little-studied problem which has a general biological significance. A comprehensive study of regulatory system functional state of modern schoolchildren will expand the understanding of the neuroendocrine mechanisms of their age development and puberty, which is very important for the scientific foundation of the health care system among younger generation. The aim of research was a comprehensive study of the age and sex characteristics of the sympathetic-adrenal system and the adrenal cortex, the ratio of their functional activity among 10-15 year old boys and girls. The observation among children lasted for 6 years continuously. The content of adrenaline and noradrenaline in daily urine based on fluorimetric method showed the state of the sympathetic-adrenal system. The functional status of the adrenal cortex was assessed by urinary excretion of 17- ketosteroids and 17-oxycorticosteroids using a colorimetric method based on Zimmermann reaction with mdinitrobenzene and and by the reaction with phenylhydrazine after enzymatic hydrolysis (Silber's and Porter's method). The statistical significance of differences was determined by Student's t-criterion. It was shown that the daily excretion of adrenaline varies slightly among the children of both sexes, while the dynamics of norepinephrine is more pronounced and oscillatory in nature, which is consistent with the concept of chromaffin tissue earlier maturation relative to sympathetic innervation in ontogenesis. At the same time they revealed multidirectional changes in the excretion of 17-ketosteroids and 17-oxycorticosteroids among 11-13 year old boys, reflecting the biological antagonism of androgens and glucocorticoids, which have protein-anabolic and catabolic effects on a body. A certain synchronicity was established in the manifestation of the mediator link functional activity of the sympathetic-adrenal system, androgen and glucocorticoid function of the adrenal cortex, which is manifested heterochronically in sex groups among 10- 12 year old girls, and 14-15 year old boys. This confirms the literature data on the presence of close functional relationship between catecholamines and corticosteroids at different levels of neurohumoral regulatory mechanism and shows the features of adaptive reactions of children during prepubertal and pubertal development

The use of mathematical modelling for improving the tissue engineering of organs and stem cell therapy

© 2016 Bentham Science Publishers.Regenerative medicine is a multidisciplinary field where continued progress relies on the incorporation of a diverse set of technologies from a wide range of disciplines within medicine, science and engineering. This review describes how one such technique, mathematical modelling, can be utilised to improve the tissue engineering of organs and stem cell therapy. Several case studies, taken from research carried out by our group, ACTREM, demonstrate the utility of mechanistic mathematical models to help aid the design and optimisation of protocols in regenerative medicine

The discovAIR project:a roadmap towards the Human Lung Cell Atlas

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The lung biological network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and the cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework program. DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions

The discovAIR project: a roadmap towards the Human Lung Cell Atlas

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The Lung Biological Network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and cell–cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework programme. discovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Human Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Human Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions

Evaluation of sympathoadrenal system and adrenal cortex functional activity among children in the age and sexaspects

© 2016, International Journal of Pharmacy and Technology. All rights reserved.The study of relationship between sympathetic-adrenal and pituitary-adrenal systems at the level of the whole organism in ontogenesis is a little-studied problem which has a general biological significance. A comprehensive study of regulatory system functional state of modern schoolchildren will expand the understanding of the neuroendocrine mechanisms of their age development and puberty, which is very important for the scientific foundation of the health care system among younger generation. The aim of research was a comprehensive study of the age and sex characteristics of the sympathetic-adrenal system and the adrenal cortex, the ratio of their functional activity among 10-15 year old boys and girls. The observation among children lasted for 6 years continuously. The content of adrenaline and noradrenaline in daily urine based on fluorimetric method showed the state of the sympathetic-adrenal system. The functional status of the adrenal cortex was assessed by urinary excretion of 17- ketosteroids and 17-oxycorticosteroids using a colorimetric method based on Zimmermann reaction with mdinitrobenzene and and by the reaction with phenylhydrazine after enzymatic hydrolysis (Silber's and Porter's method). The statistical significance of differences was determined by Student's t-criterion. It was shown that the daily excretion of adrenaline varies slightly among the children of both sexes, while the dynamics of norepinephrine is more pronounced and oscillatory in nature, which is consistent with the concept of chromaffin tissue earlier maturation relative to sympathetic innervation in ontogenesis. At the same time they revealed multidirectional changes in the excretion of 17-ketosteroids and 17-oxycorticosteroids among 11-13 year old boys, reflecting the biological antagonism of androgens and glucocorticoids, which have protein-anabolic and catabolic effects on a body. A certain synchronicity was established in the manifestation of the mediator link functional activity of the sympathetic-adrenal system, androgen and glucocorticoid function of the adrenal cortex, which is manifested heterochronically in sex groups among 10- 12 year old girls, and 14-15 year old boys. This confirms the literature data on the presence of close functional relationship between catecholamines and corticosteroids at different levels of neurohumoral regulatory mechanism and shows the features of adaptive reactions of children during prepubertal and pubertal development