4,917 research outputs found
Additive Function of Vibrio vulnificus MARTXVv and VvhA Cytolysins Promotes Rapid Growth and Epithelial Tissue Necrosis During Intestinal Infection
Vibrio vulnificus is a pathogen that causes both severe necrotizing wound infections and life-threatening food-borne infections. Food-borne infection is particularly lethal as the infection can progress rapidly to primary septicemia resulting in death from septic shock and multiorgan failure. In this study, we use both bioluminescence whole animal imaging and V. vulnificus bacterial colonization of orally infected mice to demonstrate that the secreted multifunctional-autoprocessing RTX toxin (MARTXVv) and the cytolysin/hemolysin VvhA of clinical isolate CMCP6 have an important function in the gut to promote early in vivo growth and dissemination of this pathogen from the small intestine to other organs. Using histopathology, we find that both cytotoxins can cause villi disruption, epithelial necrosis, and inflammation in the mouse small intestine. A double mutant deleted of genes for both cytotoxins was essentially avirulent, did not cause intestinal epithelial tissue damage, and was cleared from infected mice by 36 hours by an effective immune response. Therefore, MARTXVv and VvhA seem to play an additive role for pathogenesis of CMCP6 causing intestinal tissue damage and inflammation that then promotes dissemination of the infecting bacteria to the bloodstream and other organs. In the absence of these two secreted factors, we propose that this bacterium is unable to cause intestinal infection in humans
N_pN_n dependence of empirical formula for the lowest excitation energy of the 2^+ states in even-even nuclei
We examine the effects of the additional term of the type on the recently proposed empirical formula for the lowest excitation
energy of the states in even-even nuclei. This study is motivated by the
fact that this term carries the favorable dependence of the valence nucleon
numbers dictated by the scheme. We show explicitly that there is not
any improvement in reproducing by including the extra
term. However, our study also reveals that the excitation energies
, when calculated by the term alone (with the mass number
dependent term), are quite comparable to those calculated by the original
empirical formula.Comment: 14 pages, 5 figure
Polarization-sensitive quantum-optical coherence tomography
We set forth a polarization-sensitive quantum-optical coherence tomography
(PS-QOCT) technique that provides axial optical sectioning with
polarization-sensitive capabilities. The technique provides a means for
determining information about the optical path length between isotropic
reflecting surfaces, the relative magnitude of the reflectance from each
interface, the birefringence of the interstitial material, and the orientation
of the optical axis of the sample. PS-QOCT is immune to sample dispersion and
therefore permits measurements to be made at depths greater than those
accessible via ordinary optical coherence tomography. We also provide a general
Jones matrix theory for analyzing PS-QOCT systems and outline an experimental
procedure for carrying out such measurements.Comment: 15 pages, 5 figures, to appear in Physical Review
Electronic structure of YbB: Is it a Topological Insulator or not?
To resolve the controversial issue of the topological nature of the
electronic structure of YbB, we have made a combined study using density
functional theory (DFT) and angle resolved photoemission spectroscopy (ARPES).
Accurate determination of the low energy band topology in DFT requires the use
of modified Becke-Johnson exchange potential incorporating the spin-orbit
coupling and the on-site Coulomb interaction of Yb electrons as large
as 7 eV. We have double-checked the DFT result with the more precise GW band
calculation. ARPES is done with the non-polar (110) surface termination to
avoid band bending and quantum well confinement that have confused ARPES
spectra taken on the polar (001) surface termination. Thereby we show
definitively that YbB has a topologically trivial B 2-Yb 5
semiconductor band gap, and hence is a non-Kondo non-topological insulator
(TI). In agreement with theory, ARPES shows pure divalency for Yb and a -
band gap of 0.3 eV, which clearly rules out both of the previous scenarios of
- band inversion Kondo TI and - band inversion non-Kondo TI. We
have also examined the pressure-dependent electronic structure of YbB,
and found that the high pressure phase is not a Kondo TI but a
\emph{p}-\emph{d} overlap semimetal.Comment: The main text is 6 pages with 4 figures, and the supplementary
information contains 6 figures. 11 pages, 10 figures in total To be appeared
in Phys. Rev. Lett. (Online publication is around March 16 if no delays.
Lyman alpha line formation in starbursting galaxies II. Extremely Thick, Dustless, and Static HI Media
The Lya line transfer in an extremely thick medium of neutral hydrogen is
investigated by adopting an accelerating scheme in our Monte Carlo code to skip
a large number of core or resonant scatterings. This scheme reduces computing
time significantly with no sacrifice in the accuracy of the results. We applied
this numerical method to the Lya transfer in a static, uniform, dustless, and
plane-parallel medium. Two types of photon sources have been considered, the
midplane source and the uniformly distributed sources. The emergent profiles
show double peaks and absorption trough at the line-center. We compared our
results with the analytic solutions derived by previous researchers, and
confirmed that both solutions are in good agreement with each other. We
investigated the directionality of the emergent Lya photons and found that limb
brightening is observed in slightly thick media while limb darkening appears in
extremely thick media. The behavior of the directionality is noted to follow
that of the Thomson scattered radiation in electron clouds, because both Lya
wing scattering and Thomson scattering share the same Rayleigh scattering phase
function. The mean number of wing scatterings just before escape is in exact
agreement with the prediction of the diffusion approximation. The Lya photons
constituting the inner part of the emergent profiles follow the relationship
derived from the diffusion approximation. We present a brief discussion on the
application of our results to the formation of Lya broad absorption troughs and
P-Cygni type Lya profiles seen in the UV spectra of starburst galaxies.Comment: 24 papges, 12 figures, The revised version submitted to Ap
Probing Dark Energy with Baryonic Acoustic Oscillations from Future Large Galaxy Redshift Surveys
We show that the measurement of the baryonic acoustic oscillations in large
high redshift galaxy surveys offers a precision route to the measurement of
dark energy. The cosmic microwave background provides the scale of the
oscillations as a standard ruler that can be measured in the clustering of
galaxies, thereby yielding the Hubble parameter and angular diameter distance
as a function of redshift. This, in turn, enables one to probe dark energy. We
use a Fisher matrix formalism to study the statistical errors for redshift
surveys up to z=3 and report errors on cosmography while marginalizing over a
large number of cosmological parameters including a time-dependent equation of
state. With redshifts surveys combined with cosmic microwave background
satellite data, we achieve errors of 0.037 on Omega_x, 0.10 on w(z=0.8), and
0.28 on dw(z)/dz for cosmological constant model. Models with less negative
w(z) permit tighter constraints. We test and discuss the dependence of
performance on redshift, survey conditions, and fiducial model. We find results
that are competitive with the performance of future supernovae Ia surveys. We
conclude that redshift surveys offer a promising independent route to the
measurement of dark energy.Comment: submitted to ApJ, 24 pages, LaTe
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TiO2/Ferroelectric Heterostructures as Dynamic Polarization-Promoted Catalysts for Photochemical and Electrochemical Oxidation of Water
Using first-principles density functional theory calculations, we explore the chemical activity of epitaxial heterostructures of TiO2 anatase on strained polar SrTiO3 films focusing on the oxygen evolution reaction (OER), the bottleneck of water splitting. Our results show that the reactivity of the TiO2 surface is tuned by electric dipoles dynamically induced by the adsorbed species during the intermediate steps of the reaction while the initial and final steps remain unaffected. Compared to the OER on unsupported TiO2, the combined effects of the dynamically induced dipoles and epitaxial strain strongly reduce rate-limiting thermodynamic barriers and significantly improve the efficiency of the reaction.open5
Singularity Structures in Coulomb-Type Potentials in Two Body Dirac Equations of Constraint Dynamics
Two Body Dirac Equations (TBDE) of Dirac's relativistic constraint dynamics
have been successfully applied to obtain a covariant nonperturbative
description of QED and QCD bound states. Coulomb-type potentials in these
applications lead naively in other approaches to singular relativistic
corrections at short distances that require the introduction of either
perturbative treatments or smoothing parameters. We examine the corresponding
singular structures in the effective potentials of the relativistic
Schroedinger equation obtained from the Pauli reduction of the TBDE. We find
that the relativistic Schroedinger equation lead in fact to well-behaved wave
function solutions when the full potential and couplings of the system are
taken into account. The most unusual case is the coupled triplet system with
S=1 and L={(J-1),(J+1)}. Without the inclusion of the tensor coupling, the
effective S-state potential would become attractively singular. We show how
including the tensor coupling is essential in order that the wave functions be
well-behaved at short distances. For example, the S-state wave function becomes
simply proportional to the D-state wave function and dips sharply to zero at
the origin, unlike the usual S-state wave functions. Furthermore, this behavior
is similar in both QED and QCD, independent of the asymptotic freedom behavior
of the assumed QCD vector potential. Light- and heavy-quark meson states can be
described well by using a simplified linear-plus-Coulomb-type QCD potential
apportioned appropriately between world scalar and vector potentials. We use
this potential to exhibit explicitly the origin of the large pi-rho splitting
and effective chiral symmetry breaking. The TBDE formalism developed here may
be used to study quarkonia in quark-gluon plasma environments.Comment: 23 pages, 4 figure
Fluctuation-driven capacity distribution in complex networks
Maximizing robustness and minimizing cost are common objectives in the design
of infrastructure networks. However, most infrastructure networks evolve and
operate in a highly decentralized fashion, which may significantly impact the
allocation of resources across the system. Here, we investigate this question
by focusing on the relation between capacity and load in different types of
real-world communication and transportation networks. We find strong empirical
evidence that the actual capacity of the network elements tends to be similar
to the maximum available capacity, if the cost is not strongly constraining. As
more weight is given to the cost, however, the capacity approaches the load
nonlinearly. In particular, all systems analyzed show larger unoccupied
portions of the capacities on network elements subjected to smaller loads,
which is in sharp contrast with the assumptions involved in (linear) models
proposed in previous theoretical studies. We describe the observed behavior of
the capacity-load relation as a function of the relative importance of the cost
by using a model that optimizes capacities to cope with network traffic
fluctuations. These results suggest that infrastructure systems have evolved
under pressure to minimize local failures, but not necessarily global failures
that can be caused by the spread of local damage through cascading processes
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