OPE Convergence in Conformal Field Theory

We clarify questions related to the convergence of the OPE and conformal block decomposition in unitary Conformal Field Theories (for any number of spacetime dimensions). In particular, we explain why these expansions are convergent in a finite region. We also show that the convergence is exponentially fast, in the sense that the operators of dimension above Delta contribute to correlation functions at most exp(-a Delta). Here the constant a>0 depends on the positions of operator insertions and we compute it explicitly.Comment: 26 pages, 6 figures; v2: a clarifying note and two refs added; v3: note added concerning an extra constant factor in the main error estimate, misprint correcte

Pandemic influenza control in Europe and the constraints resulting from incoherent public health laws

© 2010 Martin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: With the emergence of influenza H1N1v the world is facing its first 21st century global pandemic. Severe Acute Respiratory Syndrome (SARS) and avian influenza H5N1 prompted development of pandemic preparedness plans. National systems of public health law are essential for public health stewardship and for the implementation of public health policy[1]. International coherence will contribute to effective regional and global responses. However little research has been undertaken on how law works as a tool for disease control in Europe. With co-funding from the European Union, we investigated the extent to which laws across Europe support or constrain pandemic preparedness planning, and whether national differences are likely to constrain control efforts. Methods: We undertook a survey of national public health laws across 32 European states using a questionnaire designed around a disease scenario based on pandemic influenza. Questionnaire results were reviewed in workshops, analysing how differences between national laws might support or hinder regional responses to pandemic influenza. Respondents examined the impact of national laws on the movements of information, goods, services and people across borders in a time of pandemic, the capacity for surveillance, case detection, case management and community control, the deployment of strategies of prevention, containment, mitigation and recovery and the identification of commonalities and disconnects across states. Results: Results of this study show differences across Europe in the extent to which national pandemic policy and pandemic plans have been integrated with public health laws. We found significant differences in legislation and in the legitimacy of strategic plans. States differ in the range and the nature of intervention measures authorized by law, the extent to which borders could be closed to movement of persons and goods during a pandemic, and access to healthcare of non-resident persons. Some states propose use of emergency powers that might potentially override human rights protections while other states propose to limit interventions to those authorized by public health laws. Conclusion: These differences could create problems for European strategies if an evolving influenza pandemic results in more serious public health challenges or, indeed, if a novel disease other than influenza emerges with pandemic potential. There is insufficient understanding across Europe of the role and importance of law in pandemic planning. States need to build capacity in public health law to support disease prevention and control policies. Our research suggests that states would welcome further guidance from the EU on management of a pandemic, and guidance to assist in greater commonality of legal approaches across states.Peer reviewe

A Parallel Application of Matheuristics in Data Envelopment Analysis

Data Envelopment Analysis (DEA) is a non-parametric methodology for estimating technical efficiency and benchmarking. In general, it is desirable that DEA generates the efficient closest targets as benchmarks for each assessed unit. This may be achieved through the application of the Principle of Least Action. However, the mathematical models associated with this principle are based fundamentally on combinatorial NP-hard problems, difficult to be solved. For this reason, this paper uses a parallel matheuristic algorithm, where metaheuristics and exact methods work together to find optimal solutions. Several parallel schemes are used in the algorithm, being possible for them to be configured at different stages of the algorithm. The main intention is to divide the number of problems to be evaluated in equal groups, so that they are resolved in different threads. The DEA problems to be evaluated in this paper are independent of each other, an indispensable requirement for this algorithm. In addition, taking into account that the main algorithm uses exact methods to solve the mathematical problems, different optimization software has been evaluated to compare their performance when executed in parallel. The method is competitive with exact methods, obtaining fitness close to the optimum with low computational time.J. Aparicio and M. González thank the financial support from the Spanish ‘Ministerio de Economía, Industria y Competitividad’ (MINECO), the ‘Agencia Estatal de Investigacion’ and the ‘Fondo Europeo de Desarrollo Regional’ under grant MTM2016-79765-P (AEI/FEDER, UE)

A parameterized scheme of metaheuristics with exact methods for determining the Principle of Least Action in Data Envelopment Analysis

Data Envelopment Analysis (DEA) is a nonparametric methodology for estimating technical efficiency of a set of Decision Making Units (DMUs) from a dataset of inputs and outputs. This paper is devoted to computational aspects of DEA models under the application of the Principle of Least Action. This principle guarantees that the efficient closest targets are determined as benchmarks for each assessed unit. Usually, these models have been addressed in the literature by applying unsatisfactory techniques, based fundamentally on combinatorial NPhard problems. Recently, some heuristics have been developed to partially solve these DEA models. This paper improves the heuristic methods used in previous works by applying a combination of metaheuristics and an exact method. Also, a parameterized scheme of metaheuristics is developed in order to implement metaheuristics and hybridations/combinations, adapting them to the particular problem proposed here. In this scheme, some parameters are used to study several types of metaheuristics, like Greedy Random Adaptative Search Procedure, Genetic Algorithms or Scatter Search. The exact method is included inside the metaheuristic to solve the particular model presented in this paper. A hyperheuristic is used on top of the parameterized scheme in order to search, in the space of metaheuristics, for metaheuristics that provide solutions close to the optimum. The method is competitive with exact methods, obtaining fitness close to the optimum with low computational timeJ. Aparicio and M. González thank the financial support from the Spanish ‘Ministerio de Economa, Industria y Competitividad’ (MINECO), the ‘Agencia Estatal de Investigacion’ and the ‘Fondo Europeo de Desarrollo Regional’ under grant MTM2016-79765-P (AEI/FEDER, UE).Additionally, D. Giméenez thanks the financial support from the Spanish MINECO, as well as by European Commission FEDER funds, under grant TIN2015-66972-C5-3-R

Forecasting pharmaceutical expenditure in Europe : adjusting for the impact of rebates and discounts

European healthcare systems are under constant pressure to contain healthcare expenditure. Understanding future drug expenditure is an important consideration for payers when formulating policies. QuintileIMS publishes European forecasts that are underpinned by its audited volume data and publicly available list prices. With increasing price pressures, list to net price divergence is growing, although some of this information is commercially sensitive and thus not publicly available. The objective of this study was to further develop an established forecast to account for this divergence and explore its impact