Quality of life in advanced cancer patients: the impact of sociodemographic and medical characteristics

Population-based surveys have shown that health-related quality of life (HRQL) is influenced by patients' characteristics such as age, gender, living situation and diagnoses. The present study explores the impact of such factors on the HRQL of severely ill cancer patients. The study sample included 395 cancer patients who participated in a cluster randomised trial of palliative care. Median survival was 13 weeks. HRQL assessments (using the EORTC QLQ-C30 questionnaire) were compared among subgroups of relevant patients' characteristics (ANOVA), and the significance of individual covariates was explored by multivariate linear regression. Most EORTC QLQ-C30 scores showed minor differences between genders. Higher age was associated with less sleeping disturbance, less pain and better emotional functioning. No positive impact of living with a partner was found. Performance status and/or time from assessment to death were significantly associated with most functioning and symptom scores. We concluded that although the overall impact of sociodemographic characteristics may seem less important to HRQL scores among advanced cancer patients than in general populations, age and gender should be allowed for. Performance status and closeness to death also need to be reported.   http://www.bjcancer.com © 2001 Cancer Research Campaig

Participatory modelling for the integrated sustainability assessment of water: The World Cellular Model and the MATISSE project

This paper describes the participatory process of developing and implementing a prototype model aimed at supporting the Integrated Sustainability Assessment of water resources and policy options at different scales. The model - called the World Cellular Model (WCM) focuses on the representation of agents’ behaviours and their systemic relationships with their environment. This is achieved by examining the interests, motives, cultural beliefs and structural resources that drive agents’ actions with regard to the use of stocks and flows of water, by looking at the impact of such water behaviours on the environment and on the natural ecosystems at different scales, and by examining in a coevolutionary way the impact of such environmental changes on the behaviours of agents. The WC model takes a ‘total system’, multi-scale, agent perspective. That is, agents operate in a single interrelated system in which each individual or collective agent responds to the availability and use of a set of stocks and flows of rules and/or institutions (S), energy and resources (E), information and knowledge (I) that in turn provokes environmental change (C) or impact on the social ecological system. . This model is being developed together with the use of participatory Integrated Assessment focus groups (IA-fgs) with real stakeholders to get insights about agents’ behaviours and the possible architecture of the model so as to increase its socio-ecological robustness and policy relevance. Our research is part of the EU funded project Matisse (Methods and Tools for Integrated Sustainability Assessment)

Benefits of restoring ecosystem services in urban areas

Cities are a key nexus of the relationship between people and nature and are huge centers of demand for ecosystem services and also generate extremely large environmental impacts. Current projections of rapid expansion of urban areas present fundamental challenges and also opportunities to design more livable, healthy and resilient cities (e.g. adaptation to climate change effects). We present the results of an analysis of benefits of ecosystem services in urban areas. Empirical analyses included estimates of monetary benefits from urban ecosystem services based on data from 25 urban areas in the USA, Canada, and China. Our results show that investing in ecological infrastructure in cities, and the ecological restoration and rehabilitation of ecosystems such as rivers, lakes, and woodlands occurring in urban areas, may not only be ecologically and socially desirable, but also quite often, economically advantageous, even based on the most traditional economic approaches.Peer reviewe

A prospective multicentre study in Sweden and Norway of mental distress and psychiatric morbidity in head and neck cancer patients

A Swedish/Norwegian head and neck cancer study was designed to assess prospectively the levels of mental distress and psychiatric morbidity in a heterogeneous sample of newly diagnosed head and neck cancer patients. A total of 357 patients were included. The mean age was 63 years, and 72% were males. The patients were asked to answer the HAD scale (the Hospital Anxiety and Depression scale) six times during 1 year. The number of possible or probable cases of anxiety or depression disorder was calculated according to standardized cut-offs. Approximately one-third of the patients scored as a possible or probable case of a major mood disorder at each measurement point during the study year. There were new cases of anxiety or depression at each time point. The anxiety level was highest at diagnosis, while depression was most common during treatment. Females were more anxious than males at diagnosis, and patients under 65 years of age scored higher than those over 65. Patients with lower performance status and more advanced disease reported higher levels of mental distress and more often scored as a probable or possible cases of psychiatric disorder. Our psychometric analyses supported the two-dimensional structure and stability of the HAD scale. The HAD scale seems to be the method of choice for getting valid information about the probability of mood disorder in head and neck cancer populations. The prevalence of psychiatric morbidity found in this study emphasizes the importance of improved diagnosis and treatment

Toward Visualization for Games: Theory, Design Space, and Patterns

Abstract-Electronic games are starting to incorporate in-game telemetry that collects data about player, team, and community performance on a massive scale, and as data begins to accumulate, so does the demand for effectively analyzing this data. In this paper, we use examples from both old and new games of different genres to explore the theory and design space of visualization for games. Drawing on these examples, we define a design space for this novel research topic and use it to formulate design patterns for how to best apply visualization technology to games. We then discuss the implications that this new framework will potentially have on the design and development of game and visualization technology in the future

Urbanization, Biodiversity and Ecosystem Services: Challenges and Opportunities: A Global Assessment

Urbanization is a global phenomenon and the book emphasizes that this is not just a social-technological process. It is also a social-ecological process where cities are places for nature, and where cities also are dependent on, and have impacts on, the biosphere at different scales from local to global. The book is a global assessment and delivers four main conclusions: Urban areas are expanding faster than urban populations. Half the increase in urban land across the world over the next 20 years will occur in Asia, with the most extensive change expected to take place in India and China Urban areas modify their local and regional climate through the urban heat island effect and by altering precipitation patterns, which together will have significant impacts on net primary production, ecosystem health, and biodiversity Urban expansion will heavily draw on natural resources, including water, on a global scale, and will often consume prime agricultural land, with knock-on effects on biodiversity and ecosystem services elsewhere Future urban expansion will often occur in areas where the capacity for formal governance is restricted, which will constrain the protection of biodiversity and management of ecosystem service

GiViP: A Visual Profiler for Distributed Graph Processing Systems

Analyzing large-scale graphs provides valuable insights in different application scenarios. While many graph processing systems working on top of distributed infrastructures have been proposed to deal with big graphs, the tasks of profiling and debugging their massive computations remain time consuming and error-prone. This paper presents GiViP, a visual profiler for distributed graph processing systems based on a Pregel-like computation model. GiViP captures the huge amount of messages exchanged throughout a computation and provides an interactive user interface for the visual analysis of the collected data. We show how to take advantage of GiViP to detect anomalies related to the computation and to the infrastructure, such as slow computing units and anomalous message patterns.Comment: Appears in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017

The Dynamics of Ecosystems, Biodiversity Management and Social Institutions at High Northern Latitudes

Ecosystems at high latitudes are highly dynamic, influenced by a multitude of large-scale disturbances. Due to global change processes these systems may be expected to be particularly vulnerable, affecting the sustained production of renewable wood resources and abundance of plants and animals on which local cultures depend. In this paper, we assess the implications of new understandings of high northern latitude ecosystems and what must be done to manage systems for resilience. We suggest that the focus of land management should shift from recovery from local disturbance to sustaining ecosystem functions in the face of change and disruption. The role of biodiversity as insurance for allowing a system to reorganize and develop during the disturbance and reorganization phases needs to be addressed in management and policy. We emphasize that the current concepts of ecological reserves and protected areas need to be reconsidered to developp dynamic tools for sustainable management of ecosystems in face of change. Characteristics of what may be considered as customary reserves at high latitudes are often consistent with a more dynamic view of reserves. We suggest new directions for addressing biodiversity management in dynamic landscapes at high latitudes, and provide empirical examples of insights from unconventional perspectives that may help improve the potential for sustainable management of biodiversity and the generation of ecosystem services