An economic analysis of ransomware and its welfare consequences

We present in this work an economic analysis of ransomware, a relatively new form of cyber-enabled extortion. We look at how the illegal gains of the criminals will depend on the strategies they use, examining uniform pricing and price discrimination. We also explore the welfare costs to society of such strategies. In addition, we present the results of a pilot survey which demonstrate proof of concept in evaluating the costs of ransomware attacks. We discuss at each stage whether the different strategies we analyse have been encountered already in existing malware, and the likelihood of them being implemented in the future. We hope this work will provide some useful insights for predicting how ransomware may evolve in the future

Wood Frog (Rana sylvatica) Use of Wildlife Ponds in Northcentral Arkansas

Forty-one wildlife ponds were monitored between 1988 and 1992 for breeding use by wood frogs (Rana sylvatica). Data were collected on egg deposition and pond characteristics. Breeding activity and characteristics were similar to that reported in other portions of the range of the wood frog. We also monitored 15 newly-constructed ponds to determine chronological breeding patterns. Data collected for each site indicated a significant increase (P\u3c 0.05) in the number of egg masses deposited in ponds as they age from 1-3 years during our study period. Increased chronological use of newly-constructed ponds may be due to localized population increase resulting from greater availability of breeding habita

Can self-report questionnaires create illness cognitions in middle-aged men?

Objective: To examine the effect of questionnaire context on self-reported illness cognition. Design: A single-item measure of the perceived impact of lower urinary tract symptoms (LUTS) was embedded twice in a questionnaire battery completed by community-dwelling middle-aged males (N = 1,790). The impact measure was placed in two distinct questionnaire contexts; at the end of a general somatic symptoms questionnaire, and following an illness-specific symptoms questionnaire. The order of the two questionnaire contexts was counter-balanced in a random sub-sample. Main Outcome Measures: An established single-item measure of the perceived impact of LUTS. Results: Concordance between the two single-item measures was moderate. Scores on a single-item measure of impact were significantly lower when assessed immediately following the completion of a LUTS-specific questionnaire than when assessed following the completion of a general symptoms questionnaire. There was no evidence of order effects. The observed effect was moderated by the severity of LUTS such that the difference in perceived impact scores between contexts (where general symptoms context > illness-specific context) increased as urinary symptoms increased. Conclusion: Questionnaire context systematically influenced responses on self-report measures of illness impact. The magnitude of the context effect was largest in the highest quintile of LUTS severity, a difference of >0.5 on a scale with a range of 3. These findings may have implications for situations where patient reported outcome measures are used to evaluate healthcare interventions or inform treatment decisions

The Role of ctDNA in Gastric Cancer.

Circulating tumour DNA (ctDNA) has potential applications in gastric cancer (GC) with respect to screening, the detection of minimal residual disease (MRD) following curative surgery, and in the advanced disease setting for treatment decision making and therapeutic monitoring. It can provide a less invasive and convenient method to capture the tumoural genomic landscape compared to tissue-based next-generation DNA sequencing (NGS). In addition, ctDNA can potentially overcome the challenges of tumour heterogeneity seen with tissue-based NGS. Although the evidence for ctDNA in GC is evolving, its potential utility is far reaching and may shape the management of this disease in the future. This article will review the current and future applications of ctDNA in GC

Genic Variation in White-tailed Deer from Arkansas

Liver and kidney samples of 33 white-tailed deer (Odocoileus virginianus) representing three populations in Arkansas were examined with horizontal starch gel electrophoresis. Of 17 loci examined, only PGM-1 and ES-2 exhibited polymorphism. Average individual heterozygosity, ranging from 2.3% to 4.7% with a mean of 3.1 %, was much lower than that reported for white-tailed deer in other parts of its range. The three populations examined in this study were highly similar based on Rogers\u27 genetic similarity coefficient