The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women

Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls. Serum parathyroid hormone, 25-hydroxyvitamin D3, CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were assessed. DXA of lumbar spine and femoral neck was performed to determine bone mineral density (BMD). Plasma iFGF-23 concentration was significantly higher in obese patients (by 42%) and correlated with age and BMD of proximal femur (R = −0.346; R = 0.285, resp.) but not with markers of bone turnover. However, serum phosphorus level in obese subjects was significantly lower. iFGF-23 concentration correlated significantly with body mass index (R = 0.292) and fat content (R = 0.259) in all study subjects. Moreover, a significant correlation between iFGF-23 and iPTH (R = 0.254) was found. No correlation between serum phosphorus or eGFR and plasma iFGF-23 and between eGFR and serum phosphorus was found. Elevated serum iFGF-23 concentration may partially explain lower phosphorus levels in the obese and seems not to reflect bone turnover

Zawartość metalicznych i niemetalicznych pierwiastków w homogenatach próbek tkankowych pobranych z amputowanych na poziomie uda z powodu miażdżycy kończyn dolnych. Doniesienie wstępne

Background: Metallic and non-metallic elements have influence on the development the changes within structure and function of arteries in different regions of vascular tree. The content of elements into arterial walls varies according to geographical origin of people. Material and methods: Tissue specimens were taken from the six lower limbs amputated on the level of thigh due to atherosclerosis. The mean age was 69 (57 to 84). Tissue specimens were collected from the limbs from the level of amputation, the popliteal fossa and the dorsal artery of foot. After chemical processing of the tissues homogenates determination of the content of elements using atomic emission spectrometry method with inductively coupled plasma (inductively coupled plasma optical emission spectroscopy) was performed. The content of Al, Ba, Ca, Cu, Fe, K, Mg, Mn, P, S, Sr and Zn was determined. Results: As a point of reference mean absolute value occurred from six specimens on the level of thigh was assumed as 100%. Content of non-metallic elements such as Ca, P and S rise towards to periphery of amputated limb reaching few times higher values on the level of dorsal artery of foot. Content of some metallic elements such as: Fe, Zn, K and Sr also rise towards to periphery of extremity. The Cu accumulation was the highest on the level of popliteal fossa, while Mn, Al and Mg concentration was the lowest on this same level and the highest in dorsal artery of foot. Conclusions: The influence of individual elements on development the atherosclerosis especially on necrotic changes requires further investigations. Described problem pose a preliminary report only in order to indicate the issue and to check the method of analysis

Physical activity increases the resistin concentration in hemodialyzed patients without metabolic syndrome

Beata Hornik,1 Jan Duława,2 Jan Szewieczek,3 Jacek Durmała4 1Department of Internal Nursing, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 2Department of Internal Medicine and Metabolic Diseases, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 3Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 4Department of Rehabilitation, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland Background: Resistin (RES) concentration increases in end-stage renal disease patients. However, there have been no studies defining the role of physical activity in RES concentrations in hemodialyzed (HD) patients. This study was aimed to determine metabolic and inflammatory effects, including RES, of 4-week supervised rehabilitation program in HD patients, with or without metabolic syndrome (MS). Methods: The study was completed by 28 patients aged 56.9±13.3 years (x̅ ± SD) who were HD for 50.6±73.4 months, and 30 controls aged 61.5±8.3 years with normal renal function. Both the groups were divided into two subgroups with respect to MS. Individualized supervised rehabilitation program based on physiotherapy, including exercises, was provided to each subject for 4 weeks. Baseline and post-intervention complete blood count, glycated hemoglobin (HbA1c) and levels of serum RES, leptin, adiponectin, cystatin C, erythropoietin, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), interleukin-6, transforming growth ­factor- β1, plasminogen activator inhibitor-1 homocysteine, insulin, albumin, parathyroid hormone (PTH), and phosphorus were measured. Results: Compared to controls, HD patients showed higher baseline leucocytes count and higher serum concentrations of RES, leptin, cystatin C, hs-CRP, TNF-α, homocysteine, phosphorus, PTH while hemoglobin, glucose, and albumin concentrations. A positive correlation between serum albumin and RES concentrations was observed in HD patients. Post-intervention RES increase was observed in HD patients without MS (post-intervention 34.22±8.89 vs baseline 30.16±11.04 ng/mL; P=0.046) while no change was observed in patients with MS and in the control group. Conclusion: MS modifies a RES response to the rehabilitation program in HD patients. Keywords: metabolic syndrome, hemodialysis, resistin, physical activity, cytokine