An acoustically-driven biochip: particle-cell interactions under physiological flow conditions [Abstract]

Introduction: The interaction of particulate drug carriers with cells has generally been assessed in stationary microplate assays. These setups fail to reflect the flow conditions in vivo which generate substantial hydrodynamic drag forces [1]. In order to address this shortcoming, a microfluidic biochip with the capability of imitating a wide range of shear rates and pulsation modes has been developed. This device, which is based on an incorporated surface acoustic wave pump, was used to study the interaction of targeted microparticles with epithelial cells under flow conditions

CME-HSS Interaction and Characteristics Tracked from Sun to Earth

In a thorough study, we investigate the origin of a remarkable plasma and magnetic field configuration observed in situ on June 22, 2011, near L1, which appears to be a magnetic ejecta (ME) and a shock signature engulfed by a solar wind high-speed stream (HSS). We identify the signatures as an Earth-directed coronal mass ejection (CME), associated with a C7.7 flare on June 21, 2011, and its interaction with a HSS, which emanates from a coronal hole (CH) close to the launch site of the CME. The results indicate that the major interaction between the CME and the HSS starts at a height of 1.3 R⊙ up to 3 R⊙. Over that distance range, the CME undergoes a strong north-eastward deflection of at least 30∘ due to the open magnetic field configuration of the CH. We perform a comprehensive analysis for the CME–HSS event using multi-viewpoint data (from the Solar TErrestrial RElations Observatories, the Solar and Heliospheric Observatory and the Solar Dynamics Observatory), and combined modeling efforts (nonlinear force-free field modeling, Graduated Cylindrical Shell CME modeling, and the Forecasting a CME’s Altered Trajectory – ForeCAT model). We aim at better understanding its early evolution and interaction process as well as its interplanetary propagation and related in situ signatures, and finally the resulting impact on the Earth’s magnetosphere

CME-CME Interactions as Sources of CME Geoeffectiveness : The Formation of the Complex Ejecta and Intense Geomagnetic Storm in 2017 Early September

Coronal mass ejections (CMEs) are the primary sources of intense disturbances at Earth, where their geo-effectiveness is largely determined by their dynamic pressure and internal magnetic field, which can be significantly altered during interactions with other CMEs in interplanetary space. We analyse three successive CMEs that erupted from the Sun during September 4-6, 2017, investigating the role of CME-CME interactions as source of the associated intense geomagnetic storm (Dst(min)=-142 nT on September 7). To quantify the impact of interactions on the (geo-)effectiveness of individual CMEs, we perform global heliospheric simulations with the EUHFORIA model, using observation-based initial parameters with the additional purpose of validating the predictive capabilities of the model for complex CME events. The simulations show that around 0.45 AU, the shock driven by the September 6 CME started compressing a preceding magnetic ejecta formed by the merging of two CMEs launched on September 4, significantly amplifying its B-z until a maximum factor of 2.8 around 0.9 AU. The following gradual conversion of magnetic energy into kinetic and thermal components reduced the B-z amplification until its almost complete disappearance around 1.8 AU. We conclude that a key factor at the origin of the intense storm triggered by the September 4-6, 2017 CMEs was their arrival at Earth during the phase of maximum B-z amplification. Our analysis highlights how the amplification of the magnetic field of individual CMEs in space-time due to interaction processes can be characterised by a growth, a maximum, and a decay phase, suggesting that the time interval between the CME eruptions and their relative speeds are critical factors in determining the resulting impact of complex CMEs at various heliocentric distances (helio-effectiveness).Peer reviewe

Genesis and Impulsive Evolution of the 2017 September 10 Coronal Mass Ejection

The X8.2 event of 2017 September 10 provides unique observations to study the genesis, magnetic morphology, and impulsive dynamics of a very fast coronal mass ejection (CME). Combining GOES-16/SUVI and SDO/AIA EUV imagery, we identify a hot (T ≈ 10–15 MK) bright rim around a quickly expanding cavity, embedded inside a much larger CME shell (T ≈ 1–2 MK). The CME shell develops from a dense set of large AR loops (0.5Rs) and seamlessly evolves into the CME front observed in LASCO C2. The strong lateral overexpansion of the CME shell acts as a piston initiating the fast EUV wave. The hot cavity rim is demonstrated to be a manifestation of the dominantly poloidal flux and frozen-in plasma added to the rising flux rope by magnetic reconnection in the current sheet beneath. The same structure is later observed as the core of the white-light CME, challenging the traditional interpretation of the CME three-part morphology. The large amount of added magnetic flux suggested by these observations explains the extreme accelerations of the radial and lateral expansion of the CME shell and cavity, all reaching values of 5–10 km s −2 . The acceleration peaks occur simultaneously with the first RHESSI 100–300 keV hard X-ray burst of the associated flare, further underlining the importance of the reconnection process for the impulsive CME evolution. Finally, the much higher radial propagation speed of the flux rope in relation to the CME shell causes a distinct deformation of the white-light CME front and shock

Using radio triangulation to understand the origin of two subsequent type II radio bursts

Context. Eruptive events such as coronal mass ejections (CMEs) and flares accelerate particles and generate shock waves which can arrive at Earth and can disturb the magnetosphere. Understanding the association between CMEs and CME-driven shocks is therefore highly important for space weather studies. Aims. We present a study of the CME/flare event associated with two type II bursts observed on September 27, 2012. The aim of the study is to understand the relationship between the observed CME and the two distinct shock wave signatures. Methods. The multiwavelength study of the eruptive event (CME/flare) was complemented with radio triangulation of the associated radio emission and modelling of the CME and the shock wave employing MHD simulations. Results. We found that, although temporal association between the type II bursts and the CME is good, the low-frequency type II (LF-type II) burst occurs significantly higher in the corona than the CME and its relationship to the CME is not straightforward. The analysis of the EIT wave (coronal bright front) shows the fastest wave component to be in the southeast quadrant of the Sun. This is also the quadrant in which the source positions of the LF-type II were found to be located, probably resulting from the interaction between the shock wave and a streamer. Conclusions. The relationship between the CME/flare event and the shock wave signatures is discussed using the temporal association, as well as the spatial information of the radio emission. Further, we discuss the importance and possible effects of the frequently non-radial propagation of the shock wave.Peer reviewe