Regulation by anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGFβ)of interleukin-8 production by LPS- and/ or TNFα-activated human polymorphonuclear cells

The capacity to down-regulate the production of IL-8 by LPS-activated human polymorphonuclear cells (PMN) has been demonstrated for IL-4, IL-10, and TGFβ. We compared their relative capacities and further extended this property to IL-13. We report a great heterogeneity among individuals related to the responsiveness of PMN to the IL-4 and IL-13 inhibitory effects while their response to the IL-10 effect was homogenous. The inhibitory activities were observed at the transcriptional level. IL-8 induction by TNFα was, unlike its induction by LPS, resistant to the inhibitory effects of IL-10, IL-4, IL-13 and TGFβ. Furthermore, IL-10 and IL-4 inhibitory activity were less effective when TNFα was acting synergistically with LPS to induce IL-8 production by PMN. LPS-induced cell-associated IL-8, detected in the PMN cultures, could be marginally inhibited by IL-4 and IL-10. Altogether, our data demonstrate that IL-13 is able to inhibit LPS-induced IL-8 production by human PMN, although IL-10 remains the most active anti-inflammatory cytokine. Despite the capacity of IL-4, IL-10, and IL-13 to limit the production of TNFα-induced IL-8 in a whole blood assay, none was able to inhibit this production when studying isolated human polymorphonuclear cells

Electron beam charging of insulators: A self-consistent flight-drift model

International audienceElectron beam irradiation and the self-consistent charge transport in bulk insulating samples are described by means of a new flight-drift model and an iterative computer simulation. Ballistic secondary electron and hole transport is followed by electron and hole drifts, their possible recombination and/or trapping in shallow and deep traps. The trap capture cross sections are the Poole-Frenkel-type temperature and field dependent. As a main result the spatial distributions of currents j(x,t), charges, the field F(x,t) and the potential slope V(x,t) are obtained in a self-consistent procedure as well as the time-dependent secondary electron emission rate sigma(t) and the surface potential V0(t) For bulk insulating samples the time-dependent distributions approach the final stationary state with j(x,t)=const=0 and sigma=1. Especially for low electron beam energies E0=4 keV the incorporation of mainly positive charges can be controlled by the potential VG of a vacuum grid in front of the target surface. For high beam energies E0=10, 20, and 30 keV high negative surface potentials V0=−4, −14, and −24 kV are obtained, respectively. Besides open nonconductive samples also positive ion-covered samples and targets with a conducting and grounded layer (metal or carbon) on the surface have been considered as used in environmental scanning electron microscopy and common SEM in order to prevent charging. Indeed, the potential distributions V(x) are considerably small in magnitude and do not affect the incident electron beam neither by retarding field effects in front of the surface nor within the bulk insulating sample. Thus the spatial scattering and excitation distributions are almost not affected

Electron Beam Charging of Insulators with Surface Layer and Leakage Currents

International audienceThe electron beam induced selfconsistent charge transport in layered insulators is described by means of an electron-hole fight-drift model FDM and an iterative computer simulation. Ballistic secondary electrons and holes, their attenuation and drift, as well as their recombination, trapping, and detrapping are included. Thermal and field-enhanced detrapping are described by the Poole-Frenkel effect. Furthermore, an additional surface layer with a modified electric surface conductivity is included which describes the surface leakage currents and will lead to particular charge incorporation at the interface between the surface layer and the bulk substrate

Gd disilicide nanowires attached to Si(111) steps

Self-assembled electronic devices, such as quantum dots or switchable molecules, need self-assembled nanowires as connections. We explore the growth of conducting Gd disilicide nanowires at step arrays on Si(111). Atomically smooth wires with large aspect ratios are formed at low coverage and high growth rate (length >1 micron, width 10nm, height 0.6nm). They grow parallel to the steps in the [-1 1 0 ] direction, which is consistent with a lattice match of 0.8% with the a-axis of the hexagonal silicide, together with a large mismatch in all other directions. This mechanism is similar to that observed previously on Si(100). In contrast to Si(100), the wires are always attached to step edges on Si(111) and can thus be grown selectively on regular step arrays.Comment: 3 pages including 4 figure

Towards a Proof Theory of G\"odel Modal Logics

Analytic proof calculi are introduced for box and diamond fragments of basic modal fuzzy logics that combine the Kripke semantics of modal logic K with the many-valued semantics of G\"odel logic. The calculi are used to establish completeness and complexity results for these fragments

Syndrome respiratoire aigu après inhalation de sprays imperméabilisants

Au cours de l'hiver 2002-2003, le Centre suisse d'information toxicologique a enregistré une augmentation inhabituelle de troubles respiratoires après exposition à des sprays imperméabilisants utilisés pour l'imprégnation du cuir et des textiles. Plus de 150 cas ont ainsi été rapportés. De telles épidémies sont déjà survenues au cours des vingt dernières années dans divers pays. Sur le plan clinique, des symptômes de toux, dyspnée et fièvre apparaissent dans le minutes ou les heures qui suivent l'exposition. Certains patients présentent une détresse respiratoire aiguë nécessitant une hospitalisation en soins intensifs. L'évolution clinique est favorable en quelques jours dans la majorité des cas, mais une dyspnée ou une toux chroniques pourraient persister chez certains patients. Un récent changement de formulation chimique semble être la cause de l'épidémie survenue en Suisse. Les produits incriminés ont été retirés de la vente. De nouveaux cas pourraient toutefois survenir à l'avenir en lien avec l'utilisation accrue de sprays imperméabilisants durant l'hiver et la possible commercialisation de nouveaux produits. [¨Résumé des Auteurs] A la suite de l'épidémie survenue en Suisse, l'Office fédéral de la santé publique a fait classer tous les sprays imperméabilisants pour cuirs et textiles dans la classe de toxicité 5S. Leurs emballages comporteront donc davantage d'avertissements aux utilisateurs. Il est actuellement recommandé d'employer ces sprays à l'air libre, d'éviter de s'exposer au brouillard de vaporisation (ne pas employer le spray contre le vent), et de bien laisser sécher les articles imperméabilisés à l'extérieur. L'emploi à l'intérieur est à éviter. Il ne suffit pas d'ouvir une fenêtre. Les personnes atteintes de maladies respiratoires (par exemple, asthme) devraient éviter d'utiliser elles-mêmes ces produits et ne pas se tenir à proximité d'un endroit où ils sont employés. [Auteurs, p. 2177]]]> Aerosols ; Respiratory Tract Diseases ; Environmental Exposure fre oai:serval.unil.ch:BIB_28738 2022-05-07T01:13:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_28738 Substances végétales toxiques et allergisantes. Giroud, C info:eu-repo/semantics/bookPart incollection 2003 Plantes, Pollen &amp; Allergies, vol. 3, pp. 50-63 oai:serval.unil.ch:BIB_28738FE2CF5F 2022-05-07T01:13:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_28738FE2CF5F Comparative Studies of Fluoroquinolones in the Treatment of Urinary Tract Infections info:doi:10.1093/clinids/10.supplement_1.s153 info:eu-repo/semantics/altIdentifier/doi/10.1093/clinids/10.supplement_1.s153 Malinverni, R. Glauser, M. P. info:eu-repo/semantics/article article 1988 Clinical Infectious Diseases, vol. 10, no. Supplement_1, pp. S153-S163 info:eu-repo/semantics/altIdentifier/pissn/1537-6591 info:eu-repo/semantics/altIdentifier/pissn/1058-4838 eng oai:serval.unil.ch:BIB_28739 2022-05-07T01:13:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_28739 Grössenselektive personenbezogene Staubprobenahme : Verwendung offenporiger Schäume Möhlmann, C. Aitken, R. J. Kenny, L. C. Görner, P. Vu Duc, T. Zambelli, G. info:eu-repo/semantics/article article 2003 Gefahrstoffe - Reinhaltung der Luft, vol. 63, no. 10, pp. 413-416 info:eu-repo/semantics/altIdentifier/pissn/0949-8036 ger oai:serval.unil.ch:BIB_28740 2022-05-07T01:13:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_28740 Intellectuelle ou militante? le serpent de mer fait son numéro. Kraus, C Malbois, F Messant, F Pannatier, G Perrin, C info:eu-repo/semantics/article article 2003 Nouvelles Questions Féministes, vol. volume 22, n° 1, pp. 4-12 oai:serval.unil.ch:BIB_28742 2022-05-07T01:13:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_28742 Poétique et dramaturgie: les didascalies de personnage. Exemple du théâtre de Georges Ferydeau. Myszkorowska, M info:eu-repo/semantics/article article 2003 Pratiques, vol. 119-120, pp. 35-66 oai:serval.unil.ch:BIB_286DBB5FB136 2022-05-07T01:13:32Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_286DBB5FB136 Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy. info:doi:10.1093/annonc/mdn434 info:eu-repo/semantics/altIdentifier/doi/10.1093/annonc/mdn434 info:eu-repo/semantics/altIdentifier/pmid/18790954 Baumert, B.G. Stupp, R. info:eu-repo/semantics/review article 2008 Annals of Oncology, vol. 19, no. Suppl 7, pp. vii217-vii222 info:eu-repo/semantics/altIdentifier/pissn/1569-8041 Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Lomustine; Neoplasm Recurrence, Local; Procarbazine; Prognosis; Radiotherapy; Radiotherapy Dosage; Vincristine eng https://serval.unil.ch/resource/serval:BIB_286DBB5FB136.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_286DBB5FB1362 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_286DBB5FB1362 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_286DD50ABE29 2022-05-07T01:13:32Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_286DD50ABE29 Cycling to Work : An Analysis of the Practice of Utility Cycling info:doi:10.1007/978-3-030-62256-5 info:eu-repo/semantics/altIdentifier/doi/10.1007/978-3-030-62256-5 urn:isbn:9783030622558 info:eu-repo/semantics/altIdentifier/isbn/9783030622558 urn:isbn:9783030622565 info:eu-repo/semantics/altIdentifier/isbn/9783030622565 info:eu-repo/semantics/altIdentifier/pissn/2191-530X info:eu-repo/semantics/altIdentifier/pissn/2191-5318 Rérat, Patrick info:eu-repo/semantics/book book 2021 <![CDATA[This book presents a thorough discussion of utility cycling, cycling in the urban environment, and everyday mobility. It is based on large survey answered by 14,000 participants in the bike to work action in Switzerland, and quantifies the various dimensions of utility cycling. It proposes an innovative theoretical framework to analyse and understand the various dimensions of the uses of bikes and their diversity. It addresses the factors that motivate commuters to get on their bike, and highlights the barriers to this practice between deficient infrastructures and lack of legitimacy. This research makes a diagnosis and discusses the way to develop this sustainable mode of transportation. By combining quantitative results in the form of tables, figures, and maps, and including qualitative results in the form of quotations from survey participants, this book provides a thorough and enjoyable read. It will be of interest to researchers, policy makers, advanced students in the field of urban planning, social sciences, and transportation

Focused labeled proof systems for modal logic

International audienceFocused proofs are sequent calculus proofs that group inference rules into alternating positive and negative phases. These phases can then be used to define macro-level inference rules from Gentzen's original and tiny introduction and structural rules. We show here that the inference rules of labeled proof systems for modal logics can similarly be described as pairs of such phases within the LKF focused proof system for first-order classical logic. We consider the system G3K of Negri for the modal logic K and define a translation from labeled modal formulas into first-order polarized formulas and show a strict correspondence between derivations in the two systems, i.e., each rule application in G3K corresponds to a bipole—a pair of a positive and a negative phases—in LKF. Since geometric axioms (when properly polarized) induce bipoles, this strong correspondence holds for all modal logics whose Kripke frames are characterized by geometric properties. We extend these results to present a focused labeled proof system for this same class of modal logics and show its soundness and completeness. The resulting proof system allows one to define a rich set of normal forms of modal logic proofs