699 research outputs found
Inscribed Radius Bounds for Lower Ricci Bounded Metric Measure Spaces with Mean Convex Boundary
Consider an essentially nonbranching metric measure space with the measure
contraction property of Ohta and Sturm, or with a Ricci curvature lower bound
in the sense of Lott, Sturm and Villani. We prove a sharp upper bound on the
inscribed radius of any subset whose boundary has a suitably signed lower bound
on its generalized mean curvature. This provides a nonsmooth analog to a result
of Kasue (1983) and Li (2014). We prove a stability statement concerning such
bounds and - in the Riemannian curvature-dimension (RCD) setting - characterize
the cases of equality
Best practices for HPM-assisted performance engineering on modern multicore processors
Many tools and libraries employ hardware performance monitoring (HPM) on
modern processors, and using this data for performance assessment and as a
starting point for code optimizations is very popular. However, such data is
only useful if it is interpreted with care, and if the right metrics are chosen
for the right purpose. We demonstrate the sensible use of hardware performance
counters in the context of a structured performance engineering approach for
applications in computational science. Typical performance patterns and their
respective metric signatures are defined, and some of them are illustrated
using case studies. Although these generic concepts do not depend on specific
tools or environments, we restrict ourselves to modern x86-based multicore
processors and use the likwid-perfctr tool under the Linux OS.Comment: 10 pages, 2 figure
Unchanged Fatality Rate on Austrian Ski Slopes during the COVID-19 Lockdown.
Fatalities on ski slopes are very rare, with about one death per one million skier days. Whether the fatality rate is affected by substantial changes in the number of skier days and potentially associated alterations in the structure of the skier population is unknown. Thus, we compared the fatality rate on Austrian ski slopes in the winter season of 2020/21, when skiing activities were dramatically restricted during the COVID-19 lockdown, with those of the previous winter seasons. As a consequence of COVID-19 measures, the number of skier days dropped from over 50 million in previous years to 9.2 million skier days in the winter season of 2020/21. Still, the fatality rate (6.5 deaths/10 million skier days) was not different when compared to any of the seasons from 2011/12 to 2019/20. Despite the lack of international skiers and the reduction in skier days by more than 80%, the fatality rate remained surprisingly unchanged. The weather and snowfall conditions were on average comparable to those of previous winters, and, except for nationality, the composition of the skier population appears to have remained relatively unaltered. In conclusion, the fatality rate during downhill skiing is low and the absolute fatality numbers are primarily a function of the number of skier days
Radiative transfer modelling of parsec-scale dusty warped discs
Warped discs have been found on (sub-)parsec scale in some nearby Seyfert
nuclei, identified by their maser emission. Using dust radiative transfer
simulations we explore their observational signatures in the infrared in order
to find out whether they can partly replace the molecular torus. Strong
variations of the brightness distributions are found, depending on the
orientation of the warp with respect to the line of sight. Whereas images at
short wavelengths typically show a disc-like and a point source component, the
warp itself only becomes visible at far-infrared wavelengths. A similar variety
is visible in the shapes of the spectral energy distributions. Especially for
close to edge-on views, the models show silicate feature strengths ranging from
deep absorption to strong emission for variations of the lines of sight towards
the warp. To test the applicability of our model, we use the case of the
Circinus galaxy, where infrared interferometry has revealed a highly elongated
emission component matching a warped maser disc in orientation and size. Our
model is for the first time able to present a physical explanation for the
observed dust morphology as coming from the AGN heated dust. As opposed to
available torus models, a warped disc morphology produces a variety of silicate
feature shapes for grazing lines of sight, close to an edge-on view. This could
be an attractive alternative to a claimed change of the dust composition for
the case of the nearby Seyfert 2 galaxy NGC 1068, which harbours a warped maser
disc as well.Comment: accepted by MNRA
Immune consequences of exercise in hypoxia: A narrative review.
Immune outcomes are key mediators of many health benefits of exercise and are determined by exercise type, dose (frequency/duration, intensity), and individual characteristics. Similarly, reduced availability of ambient oxygen (hypoxia) modulates immune functions depending on the hypoxic dose and the individual capacity to respond to hypoxia. How combined exercise and hypoxia (e.g., high-altitude training) sculpts immune responses is not well understood, although such combinations are becoming increasingly popular. Therefore, in this paper, we summarize the impact on immune responses of exercise and of hypoxia, both independently and together, with a focus on specialized cells in the innate and adaptive immune system. We review the regulation of the immune system by tissue oxygen levels and the overlapping and distinct immune responses related to exercise and hypoxia, then we discuss how they may be modulated by nutritional strategies. Mitochondrial, antioxidant, and anti-inflammatory mechanisms underlie many of the adaptations that can lead to improved cellular metabolism, resilience, and overall immune functions by regulating the survival, differentiation, activation, and migration of immune cells. This review shows that exercise and hypoxia can impair or complement/synergize with each other while regulating immune system functions. Appropriate acclimatization, training, and nutritional strategies can be used to avoid risks and tap into the synergistic potentials of the poorly studied immune consequences of exercising in a hypoxic state
The life cycle of starbursting circumnuclear gas discs
High-resolution observations from the sub-mm to the optical wavelength regime
resolve the central few 100pc region of nearby galaxies in great detail. They
reveal a large diversity of features: thick gas and stellar discs, nuclear
starbursts, in- and outflows, central activity, jet interaction, etc.
Concentrating on the role circumnuclear discs play in the life cycles of
galactic nuclei, we employ 3D adaptive mesh refinement hydrodynamical
simulations with the RAMSES code to self-consistently trace the evolution from
a quasi-stable gas disc, undergoing gravitational (Toomre) instability, the
formation of clumps and stars and the disc's subsequent, partial dispersal via
stellar feedback. Our approach builds upon the observational finding that many
nearby Seyfert galaxies have undergone intense nuclear starbursts in their
recent past and in many nearby sources star formation is concentrated in a
handful of clumps on a few 100pc distant from the galactic centre. We show that
such observations can be understood as the result of gravitational
instabilities in dense circumnuclear discs. By comparing these simulations to
available integral field unit observations of a sample of nearby galactic
nuclei, we find consistent gas and stellar masses, kinematics, star formation
and outflow properties. Important ingredients in the simulations are the
self-consistent treatment of star formation and the dynamical evolution of the
stellar distribution as well as the modelling of a delay time distribution for
the supernova feedback. The knowledge of the resulting simulated density
structure and kinematics on pc scale is vital for understanding inflow and
feedback processes towards galactic scales.Comment: accepted by MNRA
Hypoxia Sensing and Responses in Parkinson's Disease.
Parkinson's disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD, including mitochondrial dysfunction, dopaminergic vulnerability, and alpha-synuclein-related pathology, and highlight the link with cellular and systemic oxygen sensing. We describe cases suggesting that hypoxia may trigger Parkinsonian symptoms but also emphasize that the endogenous systems that protect from hypoxia can be harnessed to protect from PD. Finally, we provide examples of preclinical and clinical research substantiating this potential
The complexity of parsec-scaled dusty tori in AGN
Warm gas and dust surround the innermost regions of active galactic nuclei
(AGN). They provide the material for accretion onto the super-massive black
hole and they are held responsible for the orientation-dependent obscuration of
the central engine. The AGN-heated dust distributions turn out to be very
compact with sizes on scales of about a parsec in the mid-infrared. Only
infrared interferometry currently provides the necessary angular resolution to
directly study the physical properties of this dust. Size estimates for the
dust distributions derived from interferometric observations can be used to
construct a size--luminosity relation for the dust distributions. The large
scatter about this relation suggests significant differences between the dust
tori in the individual galaxies, even for nuclei of the same class of objects
and with similar luminosities. This questions the simple picture of the same
dusty doughnut in all AGN. The Circinus galaxy is the closest Seyfert 2 galaxy.
Because its mid-infrared emission is well resolved interferometrically, it is a
prime target for detailed studies of its nuclear dust distribution. An
extensive new interferometric data set was obtained for this galaxy. It shows
that the dust emission comes from a very dense, disk-like structure which is
surrounded by a geometrically thick, similarly warm dust distribution as well
as significant amounts of warm dust within the ionisation cone.Comment: 8 pages, 3 figures, to appear in the proceedings of the conference
"The central kiloparsec in Galactic Nuclei: Astronomy at High Angular
Resolution 2011", open access Journal of Physics: Conference Series (JPCS),
published by IOP Publishin
Life-style characteristics and cardiovascular risk factors in regular downhill skiers: an observational study
- …