Feedback Regulation and its Efficiency in Biochemical Networks

Intracellular biochemical networks fluctuate dynamically due to various internal and external sources of fluctuation. Dissecting the fluctuation into biologically relevant components is important for understanding how a cell controls and harnesses noise and how information is transferred over apparently noisy intracellular networks. While substantial theoretical and experimental advancement on the decomposition of fluctuation was achieved for feedforward networks without any loop, we still lack a theoretical basis that can consistently extend such advancement to feedback networks. The main obstacle that hampers is the circulative propagation of fluctuation by feedback loops. In order to define the relevant quantity for the impact of feedback loops for fluctuation, disentanglement of the causally interlocked influence between the components is required. In addition, we also lack an approach that enables us to infer non-perturbatively the influence of the feedback to fluctuation as the dual reporter system does in the feedforward network. In this work, we resolve these problems by extending the work on the fluctuation decomposition and the dual reporter system. For a single-loop feedback network with two components, we define feedback loop gain as the feedback efficiency that is consistent with the fluctuation decomposition for feedforward networks. Then, we clarify the relation of the feedback efficiency with the fluctuation propagation in an open-looped FF network. Finally, by extending the dual reporter system, we propose a conjugate feedback and feedforward system for estimating the feedback efficiency only from the statistics of the system non-perturbatively

Transient Resetting: A Novel Mechanism for Synchrony and Its Biological Examples

The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a novel mechanism, named transient resetting, for the synchronization of uncoupled biological oscillators with stimuli. This mechanism not only can unify and extend many existing results on (deterministic and stochastic) stimulus-induced synchrony, but also may actually play an important role in biological rhythms. We argue that transient resetting is a possible mechanism for the synchronization in many biological organisms, which might also be further used in medical therapy of rhythmic disorders. Examples on the synchronization of neural and circadian oscillators are presented to verify our hypothesis.Comment: 17 pages, 7 figure

p p -> j j e+/- mu+/- nu nu and j j e+/- mu-/+ nu nu at O(\alpha_{em}^6) and O(\alpha_{em}^4 \alpha_s^2) for the Study of the Quartic Electroweak Gauge Boson Vertex at LHC

We analyze the potential of the CERN Large Hadron Collider (LHC) to study the structure of quartic vector-boson interactions through the pair production of electroweak gauge bosons via weak boson fusion q q -> q q W W. In order to study these couplings we have performed a partonic level calculation of all processes p p -> j j e+/- mu+/- nu nu and pp -> j j e+/- mu-/+ nu nu at the LHC using the exact matrix elements at O(\alpha_{em}^6) and O(\alpha_{em}^4 \alpha_s^2) as well as a full simulation of the t tbar plus 0 to 2 jets backgrounds. A complete calculation of the scattering amplitudes is necessary not only for a correct description of the process but also to preserve all correlations between the final state particles which can be used to enhance the signal. Our analyses indicate that the LHC can improve by more than one order of magnitude the bounds arising at present from indirect measurements.Comment: 26 pages, 8 figures, revised version with some typos corrected, and some comments and references adde

Probing Trilinear Gauge Boson Interactions via Single Electroweak Gauge Boson Production at the LHC

We analyze the potential of the CERN Large Hadron Collider (LHC) to study anomalous trilinear vector-boson interactions W^+ W^- \gamma and W^+ W^- Z through the single production of electroweak gauge bosons via the weak boson fusion processes q q -> q q W (-> \ell^\pm \nu) and q q -> q q Z(-> \ell^+ \ell^-) with \ell = e or \mu. After a careful study of the standard model backgrounds, we show that the single production of electroweak bosons at the LHC can provide stringent tests on deviations of these vertices from the standard model prediction. In particular, we show that single gauge boson production exhibits a sensitivity to the couplings \Delta \kappa_{Z,\gamma} similar to that attainable from the analysis of electroweak boson pair production.Comment: 20 pages, 6 figure

ANOMALOUS GAUGE BOSON INTERACTIONS

We discuss the direct measurement of the trilinear vector boson couplings in present and future collider experiments. The major goals of such experiments will be the confirmation of the Standard Model (SM) predictions and the search for signals of new physics. We review our current theoretical understanding of anomalous trilinear gauge boson self-interactions. If the energy scale of the new physics is $\sim 1$ TeV, these low energy anomalous couplings are expected to be no larger than ${\cal O}(10^{-2})$. Constraints from high precision measurements at LEP and low energy charged and neutral current processes are critically reviewed.Comment: 53 pages with 17 embedded figures, LaTeX, uses axodraw.sty, figures available on request. The complete paper, is available at ftp://phenom.physics.wisc.edu/pub/preprints/1995/madph-95-871.ps.Z or http://phenom.physics.wisc.edu/pub/preprints/1995/madph-95-871.ps.Z Summary of the DPF Working Subgroup on Anomalous Gauge Boson Interactions of the DPF Long Range Planning Stud

Clocking hadronization in relativistic heavy ion collisions with balance functions

A novel state of matter has been hypothesized to exist during the early stage of relativistic heavy ion collisions, with normal hadrons not appearing until several fm/c after the start of the reaction. To test this hypothesis, correlations between charges and their associated anticharges are evaluated with the use of balance functions. It is shown that late-stage hadronization is characterized by tightly correlated charge/anticharge pairs when measured as a function of relative rapidity.Comment: 5 pages, 3 figure

Photon Structure and Quantum Fluctuation

Photon structure derives from quantum fluctuation in quantum field theory to fermion and anti-fermion, and has been an experimentally established feature of electrodynamics since the discovery of the positron. In hadronic physics, the observation of factorisable photon structure is similarly a fundamental test of the quantum field theory Quantum Chromodynamics (QCD). An overview of measurements of hadronic photon structure in e+e- and ep interactions is presented, and comparison made with theoretical expectation, drawing on the essential features of photon fluctuation into quark and anti-quark in QCD.Comment: 29 pages, 15 figures, to appear in Philosophical Transactions of the Royal Society of London (Series A: Mathematical, Physical and Engineering Sciences

Optical photometric GTC/OSIRIS observations of the young massive association Cygnus OB2

In order to fully understand the gravitational collapse of molecular clouds, the star formation process and the evolution of circumstellar disks, these phenomena must be studied in different Galactic environments with a range of stellar contents and positions in the Galaxy. The young massive association Cygnus OB2, in the Cygnus-X region, is an unique target to study how star formation and the evolution of circumstellar disks proceed in the presence of a large number of massive stars. We present a catalog obtained with recent optical observations in r,i,z filters with OSIRIS, mounted on the $10.4\,m$ GTC telescope, which is the deepest optical catalog of Cyg OB2 to date. The catalog consist of 64157 sources down to M=0.15 solar masses at the adopted distance and age of Cyg OB2. A total of 38300 sources have good photometry in all three bands. We combined the optical catalog with existing X-ray data of this region, in order to define the cluster locus in the optical diagrams. The cluster locus in the r-i vs. i-z diagram is compatible with an extinction of the optically selected cluster members in the 2.64<AV<5.57 range. We derive an extinction map of the region, finding a median value of AV=4.33 in the center of the association, decreasing toward the north-west. In the color-magnitude diagrams, the shape of the distribution of main sequence stars is compatible with the presence of an obscuring cloud in the foreground at about 850+/-25 pc from the Sun.Comment: Accepted for publication ApJS 201

Chaotic Phase Synchronization in Bursting-neuron Models Driven by a Weak Periodic Force

We investigate the entrainment of a neuron model exhibiting a chaotic spiking-bursting behavior in response to a weak periodic force. This model exhibits two types of oscillations with different characteristic time scales, namely, long and short time scales. Several types of phase synchronization are observed, such as 1 : 1 phase locking between a single spike and one period of the force and 1 : l phase locking between the period of slow oscillation underlying bursts and l periods of the force. Moreover, spiking-bursting oscillations with chaotic firing patterns can be synchronized with the periodic force. Such a type of phase synchronization is detected from the position of a set of points on a unit circle, which is determined by the phase of the periodic force at each spiking time. We show that this detection method is effective for a system with multiple time scales. Owing to the existence of both the short and the long time scales, two characteristic phenomena are found around the transition point to chaotic phase synchronization. One phenomenon shows that the average time interval between successive phase slips exhibits a power-law scaling against the driving force strength and that the scaling exponent has an unsmooth dependence on the changes in the driving force strength. The other phenomenon shows that Kuramoto's order parameter before the transition exhibits stepwise behavior as a function of the driving force strength, contrary to the smooth transition in a model with a single time scale

The Time Required to Estimate the Case Fatality Ratio of Influenza Using Only the Tip of an Iceberg: Joint Estimation of the Virulence and the Transmission Potential

Estimating the case fatality ratio (CFR) of a novel strain of influenza virus during the early stage of the pandemic is one of key epidemiological tasks to be conducted as rapid research response. Past experience during the epidemics of severe acute respiratory syndrome (SARS) and influenza A (H1N1-2009) posed several technical challenges in estimating the CFR in real time. The present study aimed to develop a simple method to estimate the CFR based on readily available datasets, that is, confirmed cases and deaths, while addressing some of the known technical issues. To assess the reliability and validity of the proposed method, we examined the minimum length of time required for the assigned CFR to be included within the 95% confidence intervals and for the estimated CFR to be below a prespecified cut-off value by means of Monte Carlo simulations. Overall, the smaller the transmission potential was, the longer it took to compare the estimated CFR against the cut-off value. If policymaking and public health response have to be made based on the CFR estimate derived from the proposed method and readily available data, it should be noted that the successful estimation may take longer than a few months