Biosorbents in the Metallic Ions Determination

This chapter provides an overview and discusses analytical strategies for metallic ions determination using solid phase extraction. Solid phase extraction (SPE) is a much-used technique for extraction and/or concentration of complex samples, so that the analytes present in low concentration were detected mainly using chromatographic methods. However, in recent years, this technique has been widely used in the development of methodologies for metallic ions determination in the deferential samples. This technique shows simplicity and rapidity comparing with other conventional techniques, liquid–liquid extraction, cloud point extraction and others. Solid phase extraction procedures become even more interesting when commercial adsorbents are exchanged for others with higher adsorptive capacity, selectivity, flexibility, economy and low environmental impacts. For this purpose, some inorganic, organic and several natural adsorbents are used. New approaches to obtain adsorbent materials from natural sources such as fungi, bacteria, industrial residues and composting materials have received attention. These materials have been used in the development of analytical methods with varied proposals, such as preconcentration or speciation of metal ions

Quadro hematologico e peso do baço de camundongos com tumor de Ehrlich na forma sólida tratados com Agaricus blazei

Este trabalho teve como objetivo avaliar a utilização do Agaricus blazei nas formas de filtrado e suspensão total aquosa (10mg/animal) na terapêutica de camundongos portadores de tumor de Ehrlich sólido, testando sua atividade anti-neoplásica. Os animais tratados diariamente com A. blazei apresentaram valores maiores dos parâmetros hematológicos (eritrograma e leucograma), e peso relativo final do baço quando comparados com o grupo controle (água destilada), porém sem diferença significativa (P>0,05)

Recomendações Para O Tratamento Da Crise Migranosa - Um Consenso Brasileiro

In this article, a group of experts in headache management of the Brazilian Headache Society developed through a consensus strategic measurements to treat a migraine attack in both the child and the adult. Particular emphasis was laid on the treatment of migraine in women, including at pregnancy, lactation and perimenstrual period. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.74326227

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL27c, a prodrug pan-PI3K inhibitor designed for local therapy, and investigate whether inhaled CL27c is effective in asthma and pulmonary fibrosis. Mice inhaling CL27c show reduced insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action. In murine models of acute or glucocorticoid-resistant neutrophilic asthma, inhaled CL27c reduces inflammation and improves lung function. Finally, inhaled CL27c administered in a therapeutic setting protects from bleomycin-induced lung fibrosis, ultimately leading to significantly improved survival. Therefore, local delivery of a pan-PI3K inhibitor prodrug reduces systemic on-target side effects but effectively treats asthma and irreversible pulmonary fibrosis

Associação Entre Doenças Metabólicas e Parâmetros Hemodinâmicos de Filhos Obesos e Suas Mães

Modelo do estudo: Estudo originalObjetivo: Verificar possíveis associações entre o perfil hemodinâmico e metabólico de crianças e adolescentes obesos e suas mães. Metodologia: Realizou-se um estudo transversal com 69 crianças e adolescentes obesos, de ambos os sexos, com faixa etária compreendida entre seis e 15 (10,6 ± 3,04) anos. Por meio de avaliações específicas foram analisadas as variáveis de composição corporal (massa corporal magra, massa de gordura em quilos e percentual), hemodinâmicas (pressão arterial sistólica e diastólica) e bioquímicas (glicemia, colesterol total e suas frações) dos filhos. Entre as mães foi realizado uma avaliação de composição corporal por meio de antropometria e impedância bioelétrica, aferição de pressão arterial e aplicação de questionário auto referido de doenças. Para o tratamento estatístico foram realizados análise descritiva, teste t de Student independente e análise de associação entre alterações maternas com seus respectivos filhos por meio de teste de Mc Nemar, adotando-se pd” 0,05. Todo o tratamento estatístico foi realizado por meio do software SPSS, 17.0. Resultados: Ser filho de mães diabéticas ou hipertensas associa-se com a presença de alterações nas variáveis de glicemia, pressão arterial sistólica ou diastólica. Quando a mãe apresenta mais de uma variável de risco cardiovascular a sua prole também possui alguma alteração metabólica ou em variáveis dos parâmetros hemodinâmicos (PA). Conclusão: No presente estudo observaram-se associações entre variáveis metabólicas e parâmetros hemodinâmicos entre crianças e adolescentes obesos com suas respectivas mães.Study Model: Original StudyObjective: To analyze possible associations between hemodynamic and metabolic profile of obese children and adolescents and their mothers. Methods: The study had longitudinal design with 69 children and adolescents, aged between six and 15 (10,6 ± 3,04) years old. Specific assessments to body composition (fat free mass, fat mass and percentage fat), blood pressure (blood pressure systolic and diastolic) and biochemical analysis of blood plasma (glucose, total cholesterol and its fractions) of children were analyzed. Among the mothers was carried out an assessment of body composition by anthropometry and bioelectrical impedance, blood pressure and application of inquiry self-report diseases. To treatment statistic were applied descriptive analyze, independent Student‘s test and test for association between maternal disorders with their children by Mc Nemar test, adopting pd” 0,05. Statistical analyses were performed using SPSS software version 17.0 (Statistical Package for Social Science, SPSS Inc,Illinois, USA). Results: Diabetic or hypertensive mothers contribute to the presence or absence of disorders in glucose, blood pressure systolic or diastolic in their children, as well as, when mothers has more than one cardiovascular risk variable their children had some disorder metabolic or hemodynamic too. Conclusion: The present study notes association between metabolic and hemodynamic variables of children and adolescents with their mothers