Behaviour and performance of lactating sows housed in different types of farrowing rooms during summer

AbstractThirty mixed-parity Landrace×Large White sows were used to evaluate the effects of the type of farrowing room on 28-day lactation behaviour under tropical conditions during summer. The sows were allocated in a completely randomised design with three treatments with 10 replicates according to parity number and body weight, with each animal being considered an experimental unit. The treatments consisted of a conventional farrowing room (T1); a conventional farrowing room with floor cooling under the sow (T2); and a semi-outdoor farrowing room without a cage and with access to a fenced field (T3). The sows from T1 and T2 groups were exposed to mean maximum and minimum environmental temperatures of 25.7 and 21.0°C, respectively, and the sows from the T3 group to average maximum and minimum environmental temperatures of 26.5 and 20.7°C, respectively. The feed consumption of T3 sows was numerically higher than the T1 and T2 sows (+9.5% on average). The body-weight loss was influenced at 28days (P<0.10) by treatment, being that the T3 sows gained weight (+4.7kg) while the T1 and T2 sows lost weight (−11.9 and −3.7kg, respectively for T1 and T2). The T3 sows showed a higher percentual litter mortality than the T1 and T2 sows (3.2% vs. 0% vs. 7.8%, respectively for T1, T2 and T3 sows). From farrowing until day 28 of lactation, the T2 and T3 sows showed higher lactation efficiency when compared with the T1 sows (72% vs. 87% vs. 88%, respectively for T1, T2 and T3 sows). The T1 sows showed higher (P<0.01) frequencies of visits to the feeder and drinker (+38% on average). The T3 sows spent more time (P<0.01) at the drinker than T1 and T2 sows (23 vs. 23 vs. 32min, respectively for T1, T2 and T3 sows). The T3 sows showed a higher (P<0.10) frequency of nursing than the other treatments (+15% on average). T1 and T2 sows were found to spend more time (P<0.01) performing other postures during 24h than sows maintained in T3 (50 vs. 51 vs. 22min/d, respectively for T1, T2 and T3). It is concluded that cooling of the floor under the sow in the conventional farrowing room or the use of semi-outdoor farrowing rooms improves the thermal environment and the lactation efficiency of the sows housed in hot ambient temperatures at 28-day lactation in the summer period, indicating an improved welfare

Recomendações Para O Tratamento Da Crise Migranosa - Um Consenso Brasileiro

In this article, a group of experts in headache management of the Brazilian Headache Society developed through a consensus strategic measurements to treat a migraine attack in both the child and the adult. Particular emphasis was laid on the treatment of migraine in women, including at pregnancy, lactation and perimenstrual period. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.74326227

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL27c, a prodrug pan-PI3K inhibitor designed for local therapy, and investigate whether inhaled CL27c is effective in asthma and pulmonary fibrosis. Mice inhaling CL27c show reduced insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action. In murine models of acute or glucocorticoid-resistant neutrophilic asthma, inhaled CL27c reduces inflammation and improves lung function. Finally, inhaled CL27c administered in a therapeutic setting protects from bleomycin-induced lung fibrosis, ultimately leading to significantly improved survival. Therefore, local delivery of a pan-PI3K inhibitor prodrug reduces systemic on-target side effects but effectively treats asthma and irreversible pulmonary fibrosis

Degradabilidade in situ de híbridos de milho e de capim-elefante colhidos em quatro estádios de maturidade

Dentre as forragens, a silagem de milho é amplamente utilizada pelos fazendeiros que visam explorar o máximo do potencial genético dos animais. No entanto, outros volumosos tropicais como o capim-elefante (Pennisetum purpureum) são mais produtivos e, portanto, mais baratos do que a silagem de milho. Nosso objetivo foi comparar a degradabilidade in situ do capim-elefante com a degradabilidade de híbridos de milho, colhidos em quatro estágios de maturidade. O experimento seguiu um delineamento de blocos ao acaso com sub-parcelas. Dois híbridos de milho: AG5011 e ZN8392 foram colhidos com 25, 30, 35 e 40% matéria seca (MS) na planta toda e separados na fração colmo + bainha + folhas e espigas. Capim elefante foi colhido 30, 40, 50 e 60 dias após o corte de nivelamento. As amostras secas e trituradas foram incubadas no rúmen por 0, 6, 12, 24, 48 e 72 h para cálculo da cinética da degradação ruminal da MS e da fibra em detergente neutro (FDN). O avanço da maturidade aumentou os teores de FDN e fibra em detergente ácido (FDA) do capim elefante e reduziu a degradabilidade da MS. Entretanto, a maturidade teve pouco efeito sobre os teores de fibra e a degradabilidade da MS da fração planta dos híbridos de milho. O capim elefante apresentou maior degradabilidade da FDN do que híbridos de milho, e não houve efeito da maturidade sobre a degradabilidade da FDN das duas espécies. A degradabilidade da fibra de capim-elefante não é pior do que a de híbridos de milho e, portanto a escolha da forragem deve ser feita com base em análises econômicas ao invés de assumir um menor potencial de produção em dietas a base de capim elefanteAmong tropical forages, corn silage is largely used by farmers trying to explore the maximum genetic potential from the animals. However, other tropical forages, such as elephant-grass (Pennisetum purpureum), are more productive and therefore cheaper to use than corn silage. Our objective was to compare the in situ degradability of elephant-grass with that from corn hybrids, all harvested at four stages of maturity. The experimental design followed a randomized block design with nested subplots. Two corn hybrids: AG5011, ZN8392 were harvested with 25, 30, 35, and 40% dry matter (DM) in the whole plant, and separated in stem + leaf sheath + leaf blade (stover), and cobs. Elephant-grass was harvested with 30, 40, 50 and 60 days after a leveling cut. Dried and ground samples were incubated in nylon bags inside the rumen for 0, 6, 12, 24, 48 and 72 h to estimate the kinetics of ruminal DM and neutral detergent fiber (NDF) degradation. The advance of maturity increased the NDF and acid detergent fiber (ADF) content in elephant-grass, and reduced its DM degradability. However, maturity had little or no effect on fiber content and DM degradability of corn stover. Elephant-grass had a higher NDF degradability than corn stover, and there was no effect of maturity on NDF degradability of either elephant-grass or corn stover. Fiber degradability of elephant-grass was not worse than that of corn stover, and therefore the choice of forage should be made on economical analysis rather than assuming an intrinsic low production potential for elephant-grass based diet