High voltage wiring harness test equipment

Projeto n.º 2013/34065 (Divmac - Projectos Automatismos e Periféricos Industriais, SA)[Excerto introdução] Este relatório tem por objetivo descrever as atividades desenvolvidas pela Associação Universidade - Empresa para o Desenvolvimento – TecMinho, no âmbito do projeto “High Voltage Wiring Harness Test Equipment”. (...)União Europeia - Fundo Europeu de Desenvolvimento RegionalQuadro de Referência Estratégica Nacional (QREN

Are there differences in auscultatory pulse in total blood flow restriction between positions, limbs and body segments?

Verification of the auscultatory pulse in total blood flow restriction (BFR) has been a limiting factor in studies due to the way in which it is evaluated and prescribed, as hemodynamic measurements can be directly affected by gravity. The aim of the present study was to compare the auscultatory pulse in BFR between positions, genders, limbs and body segments in healthy young individuals. A total of 156 subjects participated in the study, 76 of whom were male and 80 of whom were female (23.9±3.7 years, 66.5±11.5 kg, 1.67±0.07 m). After filling in registration data, anthropometry was evaluated, and BFR pressure was determined. BFR was evaluated in a randomized manner in both limbs (upper and lower) and in both segments (right and left) in the following positions: a) lying in the supine position; B) sitting with knees and trunk at 90°; and c) standing in the anatomical position. Significant differences were observed between the lying, sitting and standing positions (p0.05). The BFR point appears to differ between positions, genders, lower limbs and segments. Therefore, it is recommended that health professionals should check the BFR point in the position relating to the exercise that will be performed, taking into account gender, lower limbs and body segments

MMP-9/RECK imbalance: a mechanism associated with high-grade cervical lesions and genital infection by Human Papillomavirus (HPV) and Chlamydia trachomatis

"Manuscript"BACKGROUND: Matrix metalloproteinases (MMP) are important enzymes in the tumor microenvironment associated with progression of cervical intraepithelial neoplasia (CIN) toward squamous cell carcinoma (SCC) of the cervix. However, the role of MMPs in the inflammatory process associated with Chlamydia trachomatis infection concomitant with the carcinogenic process driven by HPV has not yet been addressed. In the present study, we analyzed the state of the MMP-9-RECK axis in cervical carcinogenesis. METHODS: The levels of MMP-9 and RECK expression were analyzed by immunocytochemistry in liquid-based cytology samples from 136 women with high-grade cervical lesions (CIN2/CIN3) and cervical SCC diagnosed by LLETZ, and in 196 women without cervical neoplasia or CIN1. Real-time qPCR was performed to analyze expression of MMP-9 and RECK in 15 cervical samples. The presence of HPV-DNA and other genital pathogens was evaluated by PCR. RESULTS: We found a higher expression of MMP-9 [OR, 4.2; 95% confidence interval (CI), 2.2-7.8] and lower expression of RECK (OR, 0.4; 95% CI, 0.2-0.7) in women with CIN2/CIN3/SCC when compared with women from the control group (no neoplasia/CIN1). A statistically significant association was also found between MMP-9/RECK imbalance and infection by alpha-9 HPV and C. trachomatis. The prevalence of C. trachomatis infection was significantly higher in women with high-grade cervical disease (OR, 3.7; 95% CI, 1.3-11.3). CONCLUSIONS: MMP-9/RECK imbalance in cervical smears is significantly associated with high-grade cervical diseases and infection by alpha-9 HPV and C. trachomatis. IMPACT: MMP-9/RECK imbalance during cervical inflammation induced by C. trachomatis might play a role in HPV-mediated cervical carcinogenesis.This work was supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), numbers 2008/03232-1 (to L.L. Villa) and 2012/09746-2 (to M.G. Discacciati and S.S. Maria-Engler) and National Counsel of Technological and Scientific Development pharmaceutical innovation (CNPQ-INCT-if; to S.S. Maria-Engler)

A 46,XX testicular disorder of sex development caused by a Wilms’ tumour Factorâ 1 (WT1) pathogenic variant

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146930/1/cge13459_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146930/2/cge13459.pd

The Bauru Basin in São Paulo and its tetrapods

Funding Information: The authors thank the editors of Derbyana, especially its Editor-in-Chief Silvio T. Hiruma, for the invitation to participate in this volume dedicated to “Advances in Paleontology”. This contribution results from FAPESP grant 2020/07997-4, to which most of the authors are affiliated. We also thank the Derbyana ad-hoc reviewers, Drs. Agustin Martinelli and Fabiano Iori, for their helpful comments to the manuscript. FIGURE 6 – Cumulative chronological distribution of the tetrapod fossil record in the Bauru Basin of São Paulo (1913-2022) compared to science and technology funding metrics and events: A – For all tetrapods; grey bars indicate total records of tables 1-5; green line indicates taxonomic richness (grey lines in Tables 1-5); pink line indicates FAPESP budget in billions of reais between 1976 and 2021 (FAPESP 2022); blue line indicates CNPq, CAPES, and FINEP budget in millions of reais between 1996 and 2018 (ESCOBAR 2019). Events indicated by arrows correspond, in chronological sequence, to the foundations of USP, “Instituto Geográfico e Geológico”, FAPESP, Unicamp, UNESP, “Instituto Geológico”, and Monte Alto Museum of Paleontology, the implementations of the Qualis list, the Lattes curriculum, the CAPES Portal de Periódicos, and the CNPq “grant”, the foundation of the Marília Museum of Paleontology, the release of the first MCT/CNPq public call for “Strengthening National Paleontology”, and the foundation of “Pedro Candolo” Museum of Paleontology. B – Separately for each recorded tetrapod group, coloured lines indicate total of records in tables 1-5 of Anura = light blue, Crocodyliformes = red, Mammalia = purple, Sauropoda = green, Squamata = yellow, Testudines = orange, and Theropoda = dark blue. Publisher Copyright: Copyright © 2022 The Institute of Electronics, Information and Communication Engineers.The Bauru Basin bears one of the best sampled tetrapod paleofaunas of Brazil, with about 70% of this diversity collected from its deposits in São Paulo. Its fossils are known since the beginning of the 20th century, coming from all stratigraphic units of the Basin cropping-out in the state, i.e., Santo Anastácio, Araçatuba, Adamantina (alternatively divided into Vale do Rio do Peixe, Presidente Prudente, and São José do Rio Preto formations), and Marília formations. Identified taxa include rare anurans, mammals, and squamates, an important set of testudines, theropods (including birds), and sauropods, in addition to one of the most diverse crocodyliform faunas known worldwide. This congregates more than fifty unique taxonomic entities, including 42 formally described species. Based on biostratigraphic correlations (including tetrapods), on few absolute ages, and other sources of evidence, the Bauru Basin deposits in São Paulo seem to be chronologically restricted to the Late Cretaceous, but further investigation is much needed. Finally, the history of research with such fossils highlights the importance of public funding for research and decentralization of university education for the advancement of science.publishersversionpublishe

XRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)

The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively studied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of the XRCC1 gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this Brazilian sample. Although the 194Trp variant was overrepresented in women reporting familial cases of breast cancer, no statistically significant differences concerning genotype distribution or intragenic interactions were found between this group and the controls. Thus, in the population analyzed by us, variants Arg194Trp and Arg399Gln did not appear to have any impact on breast cancer susceptibility

XRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)

The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively studied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of the XRCC1 gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this Brazilian sample. Although the 194Trp variant was overrepresented in women reporting familial cases of breast cancer, no statistically significant differences concerning genotype distribution or intragenic interactions were found between this group and the controls. Thus, in the population analyzed by us, variants Arg194Trp and Arg399Gln did not appear to have any impact on breast cancer susceptibility