183 research outputs found
The impact of social isolation on the quality of life in late postmenopausal women
Social isolation was the measure for prevention the coronavirus disease (COVID-19) prevalence. It required to keep staying at home and to reduce any social contacts. However, it had the actual significance for physical and psychical health among patients older than 65 years old. Especially, it affected late postmenopausal women because they have comorbid diseases which doctors should periodically follow up
SCREENING OF POTENTIAL LIGANDS FOR THE MAIN PROTEASE OF THE SARS-COV-2 CORONAVIRUS BY USING MOLECULAR DOCKING
An RNA virus from the Coronaviridae family, a subgroup of Coronavirinae, was first identified in late 2019 as the cause of severe acute respiratory infection in China.1 Despite the fact that clinical guidelines have been developed for the treatment of a new coronavirus infection, there are currently no specific medicine of preventing and treating a new coronavirus infection
Magnesium orotate influence on rabbits receiving levofloxacin thoracic aorta strength
The purpose of the study is to evaluate magnesium supplementation influence on thoracic aorta strength in levofloxacin treated rabbits.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠ°Π³Π½ΠΈΡ Π½Π° ΠΏΡΠΎΡΠ½ΠΎΡΡΡ Π³ΡΡΠ΄Π½ΠΎΠΉ Π°ΠΎΡΡΡ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°ΡΡΠΈΡ
Π»Π΅Π²ΠΎΡΠ»ΠΎΠΊΡΠ°ΡΠΈΠ½
Diastolic dysfunction in late postmenopausal patients with undifferentiated connective tissue disease and hypertension
Aim. To assess myocardial diastolic function (DF) in late postmenopausal women with undifferentiated connective tissue disease (UCTD) and hypertension (HTN).Material and methods. This cross-sectional study included 135 postmenopausal women, the median age of which was 68 years (65Γ·70,5 years). The anamnesis was collected using a standardized questionnaire. Verification of UCTD was carried out according to clinical guidelines. All patients underwent standard transthoracic echocardiography. The assessment of left ventricular (LV) DF was carried out according to the transmitral flow. LV diastolic dysfunction (DD) was classified into three types: rigid, pseudonormal, and restrictive. Statistical processing was carried out in the STATISTICA 13.0 environment. The measure of data averaging is the median, the measure of dispersion is 25%Γ·75%. The significance of differences was assessed using the Mann-Whitney test. Differences were considered significant at pΛ0,05.Results. Group 1 β 20 (14,8%) patients with verified UCTD and HTN, group 2 β 88 (65,2%) patients with HTN without UCTD, control group β 23 (30%) patients without HTN and UCTD. There were no differences in age, duration of postmenopause and body mass index between the groups. In the first group, a significant decrease in the ratio of peak early to late diastolic LV filling velocity was revealed (pΛ0,01). A significant increase in left ventricular end-systolic wall stress revealed in group 1. In 108 (100%) patients, LVDD was detected; among the patients of the control group, DD was not detected. In 8 (40%) patients in group 1, a pseudo-normal type of DD was detected, while in 12 out of 20 patients (60%) β rigid type of DD. When assessing DF in patients of group 2, a significant decrease was found in the ratio of peak early to late diastolic LV filling velocity, a significant increase in LV end-diastolic wall stress and end-diastolic pressure. In 2 out of 3 (57,80%) patients of group 2, DD of the rigid type was detected, while pseudonormal type β in 32,2% of patients in this group. Group 2 patients had a significant decrease in the early diastolic mitral annular velocity (pΛ0,01).Conclusion. The analysis of myocardial echocardiographic characteristics indicates a significant contribution of HTN-associated UCTD to the development of LVDD in postmenopausal women
6th year medical students satisfaction with the new lecture course form
βLectureβ originates from lat. Lektio-reading, systematic, consistent presentation of educational material, particular issue, topic, section, subject, scientific methods. In general a lecture is sometimes defined as a one-and-a-half or twohour systematic presentation of important problems of science in a lively and wellorganized way. The main purpose of a lecture is to provide theoretical basis for studies, to evoke interest to learning activities and specific academic discipline, to provide students with guidelines for independent work on the subject in question.ΠΠ΅ΠΊΡΠΈΡ βΠΎΡ Π»Π°Ρ. Lektio β ΡΡΠ΅Π½ΠΈΠ΅, ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅, ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°, ΠΊΠ°ΠΊΠΎΠ³ΠΎ-Π»ΠΈΠ±ΠΎ Π²ΠΎΠΏΡΠΎΡΠ°, ΡΠ΅ΠΌΡ, ΡΠ°Π·Π΄Π΅Π»Π°, ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠ°, ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π½Π°ΡΠΊΠΈ. Π ΠΎΠ±ΡΠΈΡ
ΡΠ΅ΡΡΠ°Ρ
Π»Π΅ΠΊΡΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΠΊΠ°ΠΊ ΠΏΠΎΠ»ΡΡΠΎΡΠ°-Π΄Π²ΡΡ
ΡΠ°ΡΠΎΠ²ΠΎΠ΅ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π²Π°ΠΆΠ½ΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ Π½Π°ΡΠΊΠΈ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΆΠΈΠ²ΠΎΠΉ ΠΈ Ρ
ΠΎΡΠΎΡΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΠΈ
Application of medicines containing lactose during galactosems and hypolactasia
The production and use of drugs that do not contain lactose in its composition, is an important trend in the pharmacological industry. Today it is difficult to find the same "universal" excipient as lactose. However, at the same time, the use of these drugs is impossible for patients with galactosaemia and hypolactasia.ΠΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²ΠΎ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π½Π΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
Π»Π°ΠΊΡΠΎΠ·Ρ Π² ΡΠ²ΠΎΠ΅ΠΌ ΡΠΎΡΡΠ°Π²Π΅, ΡΠ²Π»ΡΠ΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ Π² ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ. ΠΠ° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΡΡΠΆΠ΅Π»ΠΎ Π½Π°ΠΉΡΠΈ ΡΠ°ΠΊΠΎΠ΅ ΠΆΠ΅ Β«ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΠΎΠ΅Β» Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎ, ΠΊΠ°ΠΊ Π»Π°ΠΊΡΠΎΠ·Π°. ΠΠΎ Π²ΠΌΠ΅ΡΡΠ΅ Ρ ΡΠ΅ΠΌ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π°Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π³Π°Π»Π°ΠΊΡΠΎΠ·Π΅ΠΌΠΈΠ΅ΠΉ ΠΈ Π³ΠΈΠΏΠΎΠ»Π°ΠΊΡΠ°Π·ΠΈΠ΅ΠΉ
Molecular docking and virtual screening of pharmacokinetic parameters of the antiviral drug riamilovir
The article deals opportunities of in silico technologies for modeling interaction between drug molecule of riamilovir and target protein Hsp90. Another possibility of in silico technology is to predict pharmacokinetic parameters such as CYP450, ROCT, hERG inhibition and others.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ in silico ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Ρ ΡΠ°ΡΠ³Π΅ΡΠ½ΡΠΌ Π±Π΅Π»ΠΊΠΎΠΌ, Π² Π΄Π°Π½Π½ΠΎΠΌ ΡΠ»ΡΡΠ°Π΅ ΡΠΈΠ°ΠΌΠΈΠ»ΠΎΠ²ΠΈΡΠ° Ρ Π±Π΅Π»ΠΊΠΎΠΌ Hsp90. Π ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ Π²ΠΈΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³Π° ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ², ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ CYP450, ROCT, hERG ΠΈ ΠΏΡΠΎΡΠΈΠ΅
ΠΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΏΠΎ ΡΡΠ΅Π±Π½ΠΎΠΉ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π΅ "Π€Π°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡ" Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠ»ΡΡΠ΅ΡΠ°
ΠΠΎΡΠ»Π΅ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ Π€ΠΠΠ‘ ΠΠΠ Π½Π° ΠΊΠ°ΡΠ΅Π΄ΡΠ΅ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ ΡΡΠ΅Π±Π½ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡ: ΡΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½Π° ΡΠ΅Π»Ρ ΠΈ Π·Π°Π΄Π°ΡΠΈ ΡΡΠ΅Π±Π½ΠΎΠΉ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Ρ, ΡΠ²Π΅Π»ΠΈΡΠΈΠ»ΠΎΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΡΠ°ΡΠΎΠ² Π½Π° ΡΠ°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠ΅Π½ ΠΏΠ΅ΡΠ΅ΡΠ΅Π½Ρ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ². ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Ρ ΡΠ΅Π»ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠΎΠ»Π΅Π·Π½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ, ΡΡΠΎΠ²Π½Ρ ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°Π½ΠΈΡ ΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΠΊΠ°ΡΠ΅Π΄ΡΠ΅. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠ΄Π°ΡΠΈ ΡΠΊΠ·Π°ΠΌΠ΅Π½Π° ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ III ΠΊΡΡΡΠ° ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠ»ΡΡΠ΅ΡΠ° ΠΏΠΎ ΡΡΠ΅Π±Π½ΠΎΠΉ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π΅ Β«Π€Π°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΒ» Π·Π° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ ΠΏΡΡΡ Π»Π΅Ρ
Π‘ΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°Π½ΠΈΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ
Π‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°Π½ΠΈΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠ΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠ° ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ° ΠΏΠΎ Π²ΡΠ΅ΠΌ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΠΌ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ, ΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΌΠ΅Π½ΠΈΠΉ ΠΈ Π½Π°Π²ΡΠΊΠΎΠ². ΠΠ° ΠΊΠ°ΡΠ΅Π΄ΡΠ΅ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΎΠ·Π΄Π°Π½Ρ Π½ΠΎΠ²ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΡΠ΅Π±Π½ΠΎ-ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈΠ½ΡΠ΅ΡΠ½Π΅Ρ-ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅, Π·Π°Π½ΡΡΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ Π² ΠΈΠ½ΡΠ΅ΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠΎΡΠΌΠ΅ Ρ ΠΏΡΠΈΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ. ΠΠΎΠ»ΡΡΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ Π²ΠΎΠΏΡΠΎΡΠ°ΠΌ ΡΠ½ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°Π½ΠΈΡ
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