The impact of social isolation on the quality of life in late postmenopausal women

Social isolation was the measure for prevention the coronavirus disease (COVID-19) prevalence. It required to keep staying at home and to reduce any social contacts. However, it had the actual significance for physical and psychical health among patients older than 65 years old. Especially, it affected late postmenopausal women because they have comorbid diseases which doctors should periodically follow up

Diastolic dysfunction in late postmenopausal patients with undifferentiated connective tissue disease and hypertension

Aim. To assess myocardial diastolic function (DF) in late postmenopausal women with undifferentiated connective tissue disease (UCTD) and hypertension (HTN).Material and methods. This cross-sectional study included 135 postmenopausal women, the median age of which was 68 years (65÷70,5 years). The anamnesis was collected using a standardized questionnaire. Verification of UCTD was carried out according to clinical guidelines. All patients underwent standard transthoracic echocardiography. The assessment of left ventricular (LV) DF was carried out according to the transmitral flow. LV diastolic dysfunction (DD) was classified into three types: rigid, pseudonormal, and restrictive. Statistical processing was carried out in the STATISTICA 13.0 environment. The measure of data averaging is the median, the measure of dispersion is 25%÷75%. The significance of differences was assessed using the Mann-Whitney test. Differences were considered significant at p˂0,05.Results. Group 1 — 20 (14,8%) patients with verified UCTD and HTN, group 2 — 88 (65,2%) patients with HTN without UCTD, control group — 23 (30%) patients without HTN and UCTD. There were no differences in age, duration of postmenopause and body mass index between the groups. In the first group, a significant decrease in the ratio of peak early to late diastolic LV filling velocity was revealed (p˂0,01). A significant increase in left ventricular end-systolic wall stress revealed in group 1. In 108 (100%) patients, LVDD was detected; among the patients of the control group, DD was not detected. In 8 (40%) patients in group 1, a pseudo-normal type of DD was detected, while in 12 out of 20 patients (60%) — rigid type of DD. When assessing DF in patients of group 2, a significant decrease was found in the ratio of peak early to late diastolic LV filling velocity, a significant increase in LV end-diastolic wall stress and end-diastolic pressure. In 2 out of 3 (57,80%) patients of group 2, DD of the rigid type was detected, while pseudonormal type — in 32,2% of patients in this group. Group 2 patients had a significant decrease in the early diastolic mitral annular velocity (p˂0,01).Conclusion. The analysis of myocardial echocardiographic characteristics indicates a significant contribution of HTN-associated UCTD to the development of LVDD in postmenopausal women

6th year medical students satisfaction with the new lecture course form

“Lecture” originates from lat. Lektio-reading, systematic, consistent presentation of educational material, particular issue, topic, section, subject, scientific methods. In general a lecture is sometimes defined as a one-and-a-half or twohour systematic presentation of important problems of science in a lively and wellorganized way. The main purpose of a lecture is to provide theoretical basis for studies, to evoke interest to learning activities and specific academic discipline, to provide students with guidelines for independent work on the subject in question.Лекция –от лат. Lektio – чтение, систематическое, последовательное изложение учебного материала, какого-либо вопроса, темы, раздела, предмета, методов науки. В общих чертах лекцию определяют как полутора-двухчасовое систематизированное изложение важных проблем науки посредством живой и хорошо организованной речи

SCREENING OF POTENTIAL LIGANDS FOR THE MAIN PROTEASE OF THE SARS-COV-2 CORONAVIRUS BY USING MOLECULAR DOCKING

An RNA virus from the Coronaviridae family, a subgroup of Coronavirinae, was first identified in late 2019 as the cause of severe acute respiratory infection in China.1 Despite the fact that clinical guidelines have been developed for the treatment of a new coronavirus infection, there are currently no specific medicine of preventing and treating a new coronavirus infection

Оптимизация учебного процесса по учебной дисциплине "Фармакология" у студентов стоматологического факультета

После внедрения новых программ ФГОС ВПО на кафедре фармакологии и клинической фармакологии оптимизирован учебный процесс: сформулирована цель и задачи учебной дисциплины, увеличилось количество часов на самостоятельную работу студентов, пересмотрен перечень лекарственных средств. Проведено анкетирование у студентов с целью определения полезности получаемой информации, уровня преподавания и степени удовлетворенности качеством образования на кафедре. Продемонстрированы результаты мониторинга сдачи экзамена студентами III курса стоматологического факультета по учебной дисциплине «Фармакология» за последние пять лет

Application of medicines containing lactose during galactosems and hypolactasia

The production and use of drugs that do not contain lactose in its composition, is an important trend in the pharmacological industry. Today it is difficult to find the same "universal" excipient as lactose. However, at the same time, the use of these drugs is impossible for patients with galactosaemia and hypolactasia.Производство и применение лекарственных препаратов, не содержащих лактозу в своем составе, является актуальным направлением в фармакологической промышленности. На сегодняшний день тяжело найти такое же «универсальное» вспомогательное вещество, как лактоза. Но вместе с тем, использование данных препаратов невозможно для пациентов с галактоземией и гиполактазией

Molecular docking and virtual screening of pharmacokinetic parameters of the antiviral drug riamilovir

The article deals opportunities of in silico technologies for modeling interaction between drug molecule of riamilovir and target protein Hsp90. Another possibility of in silico technology is to predict pharmacokinetic parameters such as CYP450, ROCT, hERG inhibition and others.В статье рассмотрены возможности использования in silico технологий для определения возможности взаимодействия лекарственной молекулы с таргетным белком, в данном случае риамиловира с белком Hsp90. А также возможности виртуального скрининга фармакокинетических параметров, таких как ингибирование CYP450, ROCT, hERG и прочие

Magnesium orotate influence on rabbits receiving levofloxacin thoracic aorta strength

The purpose of the study is to evaluate magnesium supplementation influence on thoracic aorta strength in levofloxacin treated rabbits.Цель исследования – установить влияние магния на прочность грудной аорты лабораторных кроликов, получающих левофлоксацин

Совершенствование образовательных технологий в преподавании фармакологии

Статья посвящена проблемам совершенствования образовательных технологий в преподавании фармакологии. Необходима качественная подготовка по всем теоретическим дисциплинам для формирования клинического мышления, четкое соотношение теоретических представлений и практических умений и навыков. На кафедре фармакологии и клинической фармакологии созданы новые программы, разработан учебно-методический комплекс, в том числе интернет-тестирование, занятия проводится в интерактивной форме с привлечением современных информационных технологий. Большое внимание уделяется вопросам унификации преподавания