Wound Healing Modulation through the Local Application of Powder Collagen-Derived Treatments in an Excisional Cutaneous Murine Model

15 p.Wound healing includes dynamic processes grouped into three overlapping phases: inflammatory, proliferative, and maturation/remodeling. Collagen is a critical component of a healing wound and, due to its properties, is of great interest in regenerative medicine. This preclinical study was designed to compare the effects of a new collagen-based hydrolysate powder on wound repair to a commercial non-hydrolysate product, in a murine model of cutaneous healing. Circular excisional defects were created on the dorsal skin of Wistar rats (n = 36). Three study groups were established according to the treatment administered. Animals were euthanized after 7 and 18 days. Morphometric and morphological studies were performed to evaluate the healing process. The new collagen treatment led to the smallest open wound area throughout most of the study. After seven days, wound morphometry, contraction, and epithelialization were similar in all groups. Treated animals showed reduced granulation tissue formation and fewer inflammatory cells, and induction of vasculature with respect to untreated animals. After 18 days, animals treated with the new collagen treatment showed accelerated wound closure, significantly increased epithelialization, and more organized repair tissue. Our findings suggest that the new collagen treatment, compared to the untreated control group, produces significantly faster wound closure and, at the same time, promotes a slight progression of the reparative process compared with the rest of the groups.CIBER-BBNViscofan S.A

Brezales: biodiversidad, usos y conservación

En el trabajo se analiza la riqueza de géneros y de especies de ericáceas, particularmente de Erica, en Europa y en la Península Ibérica, así mismo se estudia la riqueza de ericáceas en la vegetación continental por rangos sintaxonómicos (clases de vegetación). Se exponen distintos modelos sobre la valoración de las comunidades de ericáceas (brezales), de acuerdo con la Directiva 92/43 CEE y se aportan datos originales, procedentes de trabajos de campos, sobre algunos brezales higrófilos de Galicia (España), en concreto se consideran criterios de abundancia, frecuencia y distancia a la tesela más próxima de la misma comunidad. En el campo de la diversidad cultural se analizan, sus nombres vernáculos, los usos directos de los brezales o de su transformación

Reinterpretación del robledal termófilo galaico-portugués: Rusco aculeati-Quercetum roboris

Amigo, J., Izco, J., Guitián, J. & Romero, M.I. Reinterpretación del robledal termófilo galaico-portugués: Pusco aculeati-Quercetum roboris. Lazaroa 19:85-98 (1998). La asociación de los robledales termófilos de Galicia y Noroeste de Portugal (Rusco aculeati-Quercetum roboris) estaba insuficientemente documentada: desde su descripción, hace 4 décadas, no se habían publicado inventarios de territorio gallego bajo dicho nombre, a pesar de que se ha estado utilizando ampliamente en la bibliografía y cartografiando como cabeza de una serie de vegetación. Para suplir esta carencia de información, hemos reunido 111 inventarios (35 de ellos nuevos) procedentes de las cuatro provincias gallegas. Reconocemos dentro de Rusco-Quercetum roboris dos subasociaciones: la típica o viletosum rivinianae y la quercetosum suberis, que proponemos como nueva; tanto la asociación como sus subasociaciones han sido tipificadas. Respecto a otras dos subasociaciones descritas con anterioridad, consideramos que una de ellas (viburnetosum tini) debe reubicarse en la asociación Arbuto-Quercetum pyrenaicae, en tanto que la otra (ericetosum arboreae) no merece tal rango

Brezales: biodiversidad, usos y conservación

Current research assesses Ericaceae genus and species richness, paying special attention to Erica species distribution in the Iberian Peninsula. In addition Ericaceae richness in the continental vegetation is studied at different syntaxonomical levels (vegetation classes). Different assessment models following 92/43/EEC Directive criteria are shown for Ericaceae communities (heathlands). New data from field studies about wet heathland distribution in Galicia (Spain) are provided, particularly abundance, frequency and nearest neighbour distance metrics. In the field of cultural diversity, names, traditional and present uses of heathlands and their changes are assessed.En el trabajo se analiza la riqueza de géneros y de especies de ericáceas, particularmente de Erica, en Europa y en la Península Ibérica, así mismo se estudia la riqueza de ericáceas en la vegetación continental por rangos sintaxonómicos (clases de vegetación). Se exponen distintos modelos sobre la valoración de las comunidades de ericáceas (brezales), de acuerdo con la Directiva 92/43 CEE y se aportan datos originales, procedentes de trabajos de campos, sobre algunos brezales higrófilos de Galicia (España), en concreto se consideran criterios de abundancia, frecuencia y distancia a la tesela más próxima de la misma comunidad. En el campo de la diversidad cultural se analizan, sus nombres vernáculos, los usos directos de los brezales o de su transformación

Wound Healing Modulation through the Local Application of Powder Collagen-Derived Treatments in an Excisional Cutaneous Murine Model

Wound healing includes dynamic processes grouped into three overlapping phases: inflammatory, proliferative, and maturation/remodeling. Collagen is a critical component of a healing wound and, due to its properties, is of great interest in regenerative medicine. This preclinical study was designed to compare the effects of a new collagen-based hydrolysate powder on wound repair to a commercial non-hydrolysate product, in a murine model of cutaneous healing. Circular excisional defects were created on the dorsal skin of Wistar rats (n = 36). Three study groups were established according to the treatment administered. Animals were euthanized after 7 and 18 days. Morphometric and morphological studies were performed to evaluate the healing process. The new collagen treatment led to the smallest open wound area throughout most of the study. After seven days, wound morphometry, contraction, and epithelialization were similar in all groups. Treated animals showed reduced granulation tissue formation and fewer inflammatory cells, and induction of vasculature with respect to untreated animals. After 18 days, animals treated with the new collagen treatment showed accelerated wound closure, significantly increased epithelialization, and more organized repair tissue. Our findings suggest that the new collagen treatment, compared to the untreated control group, produces significantly faster wound closure and, at the same time, promotes a slight progression of the reparative process compared with the rest of the groups

MAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE epsilon 4 noncarriers: results from the dementia genetics Spanish consortium

The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD [odds ratio (OR)=2.03; p=0.063], but not with AD. MAPT H1 haplotype was associated with AD risk (OR=1.12; p=0.0005). Stratification analysis showed that this association was mainly driven by APOE epsilon4 noncarriers (OR=1.14; p=0.0025). MAPT H1 was also associated with risk for PD (OR=1.30; p=0.0003) and PSP (OR=3.18; p=8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE epsilon4 AD