Four challenges in school leadership: small, private, innovative schools.

School education in India is in the process of transformation. There are efforts to tackle the most glaring problems of our national system of education: by bringing in renewed approaches such as empowering teachers not only in teaching but also in administrative decision making, providing students with opportunities to engage in self directed and reflective activities; and by establishing connections between school and society

Characterization of Function-E-Chainble Sets in Topological Space

In this paper we introduce the concept of function-E-chain between two sets in topological spaces through continuous function which is the extension of function-E-chain between two points of the space. Simple characterization of function-?-chainable sets in terms of function –E-chains between their points has been established. In case of metric space, the equivalence of E-chainability and function-E-chainability of sets is also established in this paper. Further some results of [1] have been generalized. Subject Classification: AMS (2000):54A9

Micropropagation of Azadirachta indica and assessment its fungicidal action

An effective protocol has been developed for micropropagation of Azadirachta indica using Murashige and Skoog ( MS) medium supplemented with different hormones like    1-Naphthyl acetic acid(NAA),3-Indole acetic acid(IAA),3-Indole butyric acid(IBA),6 Benzyl aminopurine (BAP),2,4- dichlorophenoxyacetic acid(2,4-D)and Kinetin.  Extracts obtained were analyzed using HPTLC. Different sample preparations were compared for action against fungi like Aspergillus niger, Penicillium sp, Aspergillus versicolor, Drechslera sp with sample from the original plant. The present in vitro procedure is more effective than the conventional techniques used in conservation and mass propagation of this medicinal plant

Erythema and Burning Pain in the Vulva: A Possible Phenotype of Erythromelalgia

We report a case of burning vulvar pain accompanied by erythema responding to an oral combination of a benzodiazepine and a beta blocker. The positive response to two medication classes used in the treatment of erythromelalgia supports the possibility of a localized manifestation of this disorder in the genital region

Pharmacogenomics to Drive COVID-19 Therapy for Best Outcome in a Low Resource Setting

Corona virus disease 2019 (COVID-19) has taken the world by storm with global infectivity and mortality of 3.5%. Since there is no specific treatment for COVID-19, several drugs have been repurposed to combat infection, these include drugs like anti-malarial – chloroquine, hydroxychloroquine, anti- diarrheal– loperamide and antipsychotic-promazine, which have been considered to be effective inhibitors as of viral binding to ACE2 receptor. The administration of these drugs is currently random and is the key factors responsible for varied treatment response, hence genes involved in drug metabolism should be analysed before planning therapy. Genes involved in metabolism of the listed drugs are ABCB1, CYP1A2, CYP2C8, CYP2C19, CYP3A4 and CYP2D6. Unpublished pharmacogenomic data from our internal cohort (75 cases) was analyzed to predict likely-responders and non-responders to propose drugs for COVID-19 drug therapy in our population. Preliminary data from random individuals without bias indicates that both anti-malarials at standard dose will benefit 98% of our cases (in absence of co-morbidities), while 11-85% of individuals would require dose reduction/alternatives for loperamide and promazine. Anti-malarials like chloroquine, hydroxychroloquine can be prescribed for prophylaxis and as first line of therapy in absence of comorbidities.  Simple genotype testing of ABCB1, CYP1A2, CYP2C19 and CYP2D6 is an indispensable tool to predict treatment outcomes of loperamide and promazine for COVID-19 patients