Book Reviews

Book Reviews: Overthrow: America's Century of Regime Change From Hawaii to Iraq by Stephen Kinzer ; Longitude and Empire: How Captain Cook's Voyages Changed the World by Brian W. Richardson ; Pacific Encounters: Art & Diversity in Polynesia 1760-1860 by Steven Hooper ; All Men Are Brothers: The Life & Times of Francis Williams Damon by Paul Berry ; Broken Trust: Greed, Mismanagement, & Political Manipulation at America's Largest Charitable Trust by Samuel P. King and Randall W. Roth ; Crowning the Nice Girl: Gender, Ethnicity, and Culture in Hawai'i's Cherry Blossom Festival by Christine R. Yano ; Combat Chaplain: The Personal Story of the World War II Chaplain of the Japanese American 100th Battalion by Israel A. S. Yost ; Hawaiian Volcanoes by Clarence Edward Dutton ; Reworking Race: The Making of Hawaii's Interracial Labor Movement by Moon-Kie Jung ; Islands in a Far Sea: The Fate of Nature in Hawai'i by John L. Culliney

Identifying and Quantifying Genotypes in Polyclonal Infections due to Single Species

The combination of real-time PCR and capillary electrophoresis permits the rapid identification and quantification of pathogen genotypes

Pathogen prevalence and human mate preferences

Members of host species in pathogen-host coevolutionary races may be selected to choose mates who possess features of physical appearance associated with pathogen resistance. Human data from 29 cultures indicate that people in geographical areas carrying relatively greater prevalences of pathogens value a mate's physical attractiveness more than people in areas with relatively little pathogen incidence. The relationship between pathogen prevalence and the value people place on physical attractiveness remained strong even after potential confounds such as distance from the equator, geographical region, and average income were statistically controlled for. Discussion focuses on potential limitations of the data, alternative explanations for the findings, and the nature of adaptions to the problems posed by pathogen prevalence.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30928/1/0000598.pd

Transcription Factors Mat2 and Znf2 Operate Cellular Circuits Orchestrating Opposite- and Same-Sex Mating in Cryptococcus neoformans

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic transition from a unicellular yeast to multicellular hyphae during opposite sex (mating) and unisexual reproduction (same-sex mating). Opposite- and same-sex mating are induced by similar environmental conditions and involve many shared components, including the conserved pheromone sensing Cpk1 MAPK signal transduction cascade that governs the dimorphic switch in C. neoformans. However, the homeodomain cell identity proteins Sxi1α/Sxi2a encoded by the mating type locus that are essential for completion of sexual reproduction following cell–cell fusion during opposite-sex mating are dispensable for same-sex mating. Therefore, identification of downstream targets of the Cpk1 MAPK pathway holds the key to understanding molecular mechanisms governing the two distinct developmental fates. Thus far, homology-based approaches failed to identify downstream transcription factors which may therefore be species-specific. Here, we applied insertional mutagenesis via Agrobacterium-mediated transformation and transcription analysis using whole genome microarrays to identify factors involved in C. neoformans differentiation. Two transcription factors, Mat2 and Znf2, were identified as key regulators of hyphal growth during same- and opposite-sex mating. Mat2 is an HMG domain factor, and Znf2 is a zinc finger protein; neither is encoded by the mating type locus. Genetic, phenotypic, and transcriptional analyses of Mat2 and Znf2 provide evidence that Mat2 is a downstream transcription factor of the Cpk1 MAPK pathway whereas Znf2 functions as a more terminal hyphal morphogenesis determinant. Although the components of the MAPK pathway including Mat2 are not required for virulence in animal models, Znf2, as a hyphal morphology determinant, is a negative regulator of virulence. Further characterization of these elements and their target circuits will reveal genes controlling biological processes central to fungal development and virulence

The foraging benefits of information and the penalty of ignorance. – Oikos 112

Patch use theory and the marginal value theorem predict that a foraging patch should be abandoned when the costs and benefits of foraging in the patch are equal. This has generally been interpreted as all patches being abandoned when their instantaneous intake rate equals the foraging costs. Bayesian foraging / patch departure is based on a prior estimate of patch qualities and sampling information from the current patch / predicts that instantaneous quitting harvest rates sometimes are not constant across patches but increase with search time in the patch. That is, correct Bayesian foraging theory has appeared incompatible with the widely accepted cost/benefit theories of foraging. In this paper we reconcile Bayesian foraging with cost/benefit theories. The general solution is that a patch should be left not when instantaneous quitting harvest rate reaches a constant level, but when potential quitting harvest rate does. That is, the forager should base its decision on the value now and in the future until the patch is left. We define the difference between potential and instantaneous quitting harvest rates as the foraging benefit of information, FBI. For clumped prey the FBI is positive, and by including this additional benefit of patch harvest the forager is able to reduce its penalty of ignorance