986 research outputs found
Electronic Control of Spin Alignment in pi-Conjugated Molecular Magnets
Intramolecular spin alignment in pi-conjugated molecules is studied
theoretically in a model of a Peierls-Hubbard chain coupled with two localized
spins. By means of the exact diagonalization technique, we demonstrate that a
spin singlet (S=0) to quartet (S=3/2) transition can be induced by electronic
doping, depending on the chain length, the positions of the localized spins,
and the sign of the electron-spin coupling. The calculated results provides a
theoretical basis for understanding the mechanism of spin alignment recently
observed in a diradical donor molecule.Comment: 4 pages, 4 figures, Physical Review Letters (in press
Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases
Parathyroid hormone-related peptide is a regulatory protein implicated in the pathogenesis of bone metastases, particularly in breast carcinoma. Parathyroid hormone-related peptide is widely expressed in primary prostate cancers but there are few reports of its expression in prostatic metastases. The aim of this study was to examine the expression of parathyroid hormone-related peptide and its receptor in matched primary and in bone metastatic tissue from patients with untreated adenocarcinoma of the prostate. Eight-millimetre trephine iliac crest bone biopsies containing metastatic prostate cancer were obtained from 14 patients from whom matched primary tumour tissue was also available. Histological grading was performed by an independent pathologist. The cellular location of mRNA for parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor was identified using in situ hybridization with 35S-labelled probe. Expression of parathyroid hormone-related peptide and its receptor was described as uniform, heterogenous or negative within the tumour cell population. Parathyroid hormone-related peptide expression was positive in 13 out of 14 primary tumours and in all 14 metastases. Receptor expression was evident in all 14 primaries and 12 out of 14 metastases. Co-expression of parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor was common (13 primary tumours, 12 metastases). The co-expression of parathyroid hormone-related peptide and its receptor suggest that autocrine parathyroid hormone-related peptide mediated stimulation may be a mechanism of escape from normal growth regulatory pathways. The high frequency of parathyroid hormone-related peptide expression in metastases is consistent with a role in the pathogenesis of bone metastases
A new look at low-energy nuclear reaction (LENR) research: a response to Shanahan
In his criticisms of the review article on LENR by Krivit and Marwan, Shanahan has raised a number of issues in the areas of calorimetry, heat after death, elemental transmutation, energetic particle detection using CR-39, and the temporal correlation between heat and helium-4. These issues are addressed by the researchers who conducted the original work that was discussed in the Krivit-Marwan (K&M) review paper
Measurement of the electron transmission rate of the gating foil for the TPC of the ILC experiment
We have developed a gating foil for the time projection chamber envisaged as
a central tracker for the international linear collider experiment. It has a
structure similar to the Gas Electron Multiplier (GEM) with a higher optical
aperture ratio and functions as an ion gate without gas amplification. The
transmission rate for electrons was measured in a counting mode for a wide
range of the voltages applied across the foil using an Fe source and a
laser in the absence of a magnetic field. The blocking power of the foil
against positive ions was estimated from the electron transmissions.Comment: 25 pages containing 14 figures and 1 tabl
Interhemispheric Interactions between the Human Primary Somatosensory Cortices
In the somatosensory domain it is still unclear at which processing stage information reaches the opposite hemispheres. Due to dense transcallosal connections, the secondary somatosensory cortex (S2) has been proposed to be the key candidate for interhemispheric information transfer. However, recent animal studies showed that the primary somatosensory cortex (S1) might as well account for interhemispheric information transfer. Using paired median nerve somatosensory evoked potential recordings in humans we tested the hypothesis that interhemispheric inhibitory interactions in the somatosensory system occur already in an early cortical processing stage such as S1. Conditioning right S1 by electrical median nerve (MN) stimulation of the left MN (CS) resulted in a significant reduction of the N20 response in the target (left) S1 relative to a test stimulus (TS) to the right MN alone when the interstimulus interval between CS and TS was between 20 and 25 ms. No such changes were observed for later cortical components such as the N20/P25, N30, P40 and N60 amplitude. Additionally, the subcortically generated P14 response in left S1 was also not affected. These results document the existence of interhemispheric inhibitory interactions between S1 in human subjects in the critical time interval of 20â25 ms after median nerve stimulation
Sheared Solid Materials
We present a time-dependent Ginzburg-Landau model of nonlinear elasticity in
solid materials. We assume that the elastic energy density is a periodic
function of the shear and tetragonal strains owing to the underlying lattice
structure. With this new ingredient, solving the equations yields formation of
dislocation dipoles or slips. In plastic flow high-density dislocations emerge
at large strains to accumulate and grow into shear bands where the strains are
localized. In addition to the elastic displacement, we also introduce the local
free volume {\it m}. For very small the defect structures are metastable
and long-lived where the dislocations are pinned by the Peierls potential
barrier. However, if the shear modulus decreases with increasing {\it m},
accumulation of {\it m} around dislocation cores eventually breaks the Peierls
potential leading to slow relaxations in the stress and the free energy
(aging). As another application of our scheme, we also study dislocation
formation in two-phase alloys (coherency loss) under shear strains, where
dislocations glide preferentially in the softer regions and are trapped at the
interfaces.Comment: 16pages, 11figure
Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
BACKGROUND: Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit growth in some cancer cell lines but has not been studied in pancreatic cancer. We hypothesized that apigenin would inhibit pancreatic cancer cell growth in vitro. RESULTS: Apigenin caused both time- and concentration-dependent inhibition of DNA synthesis and cell proliferation in four pancreatic cancer cell lines. Apigenin induced G2/M phase cell cycle arrest. Apigenin reduced levels of cyclin A, cyclin B, phosphorylated forms of cdc2 and cdc25, which are all proteins required for G2/M transition. CONCLUSION: Apigenin inhibits growth of pancreatic cancer cells through suppression of cyclin B-associated cdc2 activity and G2/M arrest, and may be a valuable drug for the treatment or prevention of pancreatic cancer
Relative finger position influences whether you can localize tactile stimuli
To investigate whether the relative positions of the fingers influence tactile localization, participants were asked to localize tactile stimuli applied to their fingertips. We measured the location and rate of errors for three finger configurations: fingers stretched out and together so that they are touching each other, fingers stretched out and spread apart maximally and fingers stretched out with the two hands on top of each other so that the fingers are interwoven. When the fingers contact each other, it is likely that the error rate to the adjacent fingers will be higher than when the fingers are spread apart. In particular, we reasoned that localization would probably improve when the fingers are spread. We aimed at assessing whether such adjacency was measured in external coordinates (taking proprioception into account) or on the body (in skin coordinates). The results confirmed that the error rate was lower when the fingers were spread. However, there was no decrease in error rate to neighbouring fingertips in the fingers spread condition in comparison with the fingers together condition. In an additional experiment, we showed that the lower error rate when the fingers were spread was not related to the continuous tactile input from the neighbouring fingers when the fingers were together. The current results suggest that information from proprioception is taken into account in perceiving the location of a stimulus on one of the fingertips
What factor within the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) criteria is most strongly correlated with trauma induced DIC? A retrospective study using thromboelastometry in a single center in Japan
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