Improvement of the target sensitivity in DECIGO by optimizing its parameters for quantum noise including the effect of diffraction loss

DECIGO is the future Japanese gravitational wave detector in outer space. We previously set the default design parameters to provide a good target sensitivity to detect the primordial gravitational waves (GWs). However, the updated upper limit of the primordial GWs by the Planck observations motivated us for further optimization of the target sensitivity. Previously, we had not considered optical diffraction loss due to the very long cavity length. In this paper, we optimize various DECIGO parameters by maximizing the signal-to-noise ratio (SNR), for the primordial GWs to quantum noise including the effects of diffraction loss. We evaluated the power spectrum density for one cluster in DECIGO utilizing the quantum noise of one differential Fabry-Perot interferometer. Then we calculated the SNR by correlating two clusters in the same position. We performed the optimization for two cases: the constant mirror-thickness case and the constant mirror-mass case. As a result, we obtained the SNR dependence on the mirror radius, which also determines various DECIGO parameters. This result is the first step toward optimizing the DECIGO design by considering the practical constraints on the mirror dimension and implementing other noise sources.Comment: 13 pages, 12 figure

Optimization of quantum noise in space gravitational-wave antenna DECIGO with optical-spring quantum locking considering mixture of vacuum fluctuations in homodyne detection

Quantum locking using optical spring and homodyne detection has been devised to reduce quantum noise that limits the sensitivity of DECIGO, a space-based gravitational wave antenna in the frequency band around 0.1 Hz for detection of primordial gravitational waves. The reduction in the upper limit of energy density ${\Omega}_{\mathrm{GW}}$ from $2{\times}10^{-15}$ to $1{\times}10^{-16}$, as inferred from recent observations, necessitates improved sensitivity in DECIGO to meet its primary science goals. To accurately evaluate the effectiveness of this method, this paper considers a detection mechanism that takes into account the influence of vacuum fluctuations on homodyne detection. In addition, an advanced signal processing method is devised to efficiently utilize signals from each photodetector, and design parameters for this configuration are optimized for the quantum noise. Our results show that this method is effective in reducing quantum noise, despite the detrimental impact of vacuum fluctuations on its sensitivity.Comment: 12 pages, 5 figure

Displacement-noise-free interferometeric gravitational-wave detector using unidirectional neutrons with four speeds

For further gravitational wave (GW) detections, it is significant to invent a technique to reduce all kinds of mirror displacement noise dominant at low frequencies for ground-based detectors. The neutron displacement-noise-free interferometer (DFI) is one of the tools to reduce all the mirror displacement noise at lower frequencies. In this paper, we describe a further simplified configuration of a neutron DFI in terms of neutron incidence direction. In the new configuration, neutrons enter the interferometer with unidirectional incidence at four speeds as opposed to two bidirectional incidences of opposite directions at two speeds as reported previously. This simplification of the neutron DFI is significant for proof-of-principle experiments

First-step experiment in developing optical-spring quantum locking for DECIGO: sensitivity optimization for simulated quantum noise by completing the square

DECi-hertz Interferometer Gravitational Wave Observatory (DECIGO) is a future mission for a space-borne laser interferometer. DECIGO has 1,000-km-long arm cavities mainly to detect the primordial gravitational waves (PGW) at lower frequencies around 0.1 Hz. Observations in the electromagnetic spectrum have lowered the bounds on the upper limit of PGW energy density ($\Omega_{\rm gw} \sim 10^{-15} \to 10^{-16}$). As a result, DECIGO's target sensitivity, which is mainly limited by quantum noise, needs further improvement. To maximize the feasibility of detection while constrained by DECIGO's large diffraction loss, a quantum locking technique with an optical spring was theoretically proposed to improve the signal-to-noise ratio of the PGW. In this paper, we experimentally verify one key element of the optical-spring quantum locking: sensitivity optimization by completing the square of multiple detector outputs. This experiment is operated on a simplified tabletop optical setup with classical noise simulating quantum noise. We succeed in getting the best of the sensitivities with two different laser powers by the square completion method.Comment: 10 pages, 14 figure

Candida albicans repetitive elements display epigenetic diversity and plasticity

Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here, we address this question by analysing the chromatin state associated with DNA repeats in the human fungal pathogen Candida albicans. Our analyses indicate that, contrary to model systems, each type of repetitive element is assembled into a distinct chromatin state. Classical Sir2-dependent hypoacetylated and hypomethylated chromatin is associated with the rDNA locus while telomeric regions are assembled into a weak heterochromatin that is only mildly hypoacetylated and hypomethylated. Major Repeat Sequences, a class of tandem repeats, are assembled into an intermediate chromatin state bearing features of both euchromatin and heterochromatin. Marker gene silencing assays and genome-wide RNA sequencing reveals that C. albicans heterochromatin represses expression of repeat-associated coding and non-coding RNAs. We find that telomeric heterochromatin is dynamic and remodelled upon an environmental change. Weak heterochromatin is associated with telomeres at 30?°C, while robust heterochromatin is assembled over these regions at 39?°C, a temperature mimicking moderate fever in the host. Thus in C. albicans, differential chromatin states controls gene expression and epigenetic plasticity is linked to adaptation

Candida albicans, a distinctive fungal model for cellular aging study

The unicellular eukaryotic organisms represent the popular model systems to understand aging in eukaryotes. Candida albicans, a polymorphic fungus, appears to be another distinctive unicellular aging model in addition to the budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe. The two types of Candida cells, yeast (blastospore) form and hyphal (filamentous) form, have similar replicative lifespan. Taking the advantage of morphologic changes, we are able to obtain cells of different ages. Old Candida cells tend to accumulate glycogen and oxidatively damaged proteins. Deletion of the SIR2 gene causes a decrease of lifespan, while insertion of an extra copy of SIR2 extends lifespan, indicating that like in S. cerevisiae, Sir2 regulates cellular aging in C. albicans. Interestingly, Sir2 deletion does not result in the accumulation of extra-chromosomal rDNA molecules, but influences the retention of oxidized proteins in mother cells, suggesting that the extra-chromosomal rDNA molecules may not be associated with cellular aging in C. albicans. This novel aging model, which allows efficient large-scale isolation of old cells, may facilitate biochemical characterizations and genomics/proteomics studies of cellular aging, and help to verify the aging pathways observed in other organisms including S. cerevisiae

Inhibition of the Nicotinic Acetylcholine Receptors by Cobra Venom α-Neurotoxins: Is There a Perspective in Lung Cancer Treatment?

Nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nAChRs) and the activation of downstream pathways that block apoptosis and promote neo-angiogenesis. The nAChRs of the α7 subtype are present on a wide variety of cancer cells and their inhibition by cobra venom neurotoxins has been proposed in several articles and reviews as a potential innovative lung cancer therapy. However, since part of the published results was recently retracted, we believe that the antitumoral activity of cobra venom neurotoxins needs to be independently re-evaluated