Expression of TLR1-10 and caspase-3 alfa at women with early miscarriages

Toll-like receptors (TLR) are the first signal receptors of innate immunity, recognizing bacteria and viruses and promoting development of inflammation through the activation of proinflammatory cytokines secretion (1). In animal models it was shown, that TLRs play role in pathogenesis of miscarriages (2, 3) and can influence to trophoblast apoptosis. The aim of research was to investigate study specialty of mRNA expression of TLR1-10 and caspase-3a in endometrium at patients with early miscarriagesyesBelgorod State Universit

The role of RIG-I, AIM2 and IFI16 receptors for viral RNA and DNA in the pathogenesis of spontaneous and early missed miscarriage

Aim: to identify the features of the expression of mRNA of intracellular RIG-I, IFI16 and AIM2 receptors for viral RNA and DNA, and their signaling pathway proteins in the decidual tissue of patients with spontaneous and early missed miscarriage

Pathological damage of thyroidopathy and the prevalence of thyroid diseases in children of the Perm region

Relevance. Thyroid diseases in children and adolescents rank first in the structure of endocrine pathology. An issue related to comparability of data on prevalence obtained with different procedures is vital given the necessity to intensify activities aimed at optimizing prevention of thyroid pathology.The aim. Comparative analysis of pathological lesions of thyropathies and the prevalence of thyroid gland diseases in children and adolescents living in the territory of the Perm region.Materials and methods. Prevalence of thyroid diseases was analyzed based on data taken from Statistic Form No. 12. Pathological damage caused by thyroid diseases was calculated based on results produced by medical examinations that included laboratory tests, ultrasound scanning of the thyroid gland, and a check-up by an endocrinologist. Calculation results were then compared with data taken from statistic reports. Influence exerted by sex and age on the growth in thyrotrophic hormone contents and thyroid gland volume was assessed by analyzing values in one-factor logistic regression models.Results. Prevalence of thyroid diseases, endemic goiter and subclinical hypothyroidism tends to decrease among children living in Perm region (р = 0.003–0.015) but prevalence of thyroiditis remains stable (р = 0.794). Having assessed prevalence among teenagers, we did not reveal any dynamics in prevalence of thyroid diseases and thyroiditis (р = 0.129–0.248); prevalence of endemic goiter went down in this age group (р = 0.008) whereas prevalence of subclinical hypothyroidism grew due to iodine deficiency (р = 0.012). The difference between pathological damage and prevalence of thyroid diseases reached 4.8–38.6 times. Having analyzed created logistic models, we were not able to identify sex or age as predictors of thyroid pathology occurrence.Conclusion. Prevalence of thyroid pathology was established to be by 4.8–38.6 times lower than pathological damage. Iodine deficiency on a given territory calls for developing regional medical and prevention programs aimed at diagnosing and preventing thyroid diseases caused by it

Expression of TLR1-10 and caspase-3 alfa at women with early miscarriages

yesToll-like receptors (TLR) are the first signal receptors of innate immunity, recognizing bacteria and viruses and promoting development of inflammation through the activation of proinflammatory cytokines secretion (1). In animal models it was shown, that TLRs play role in pathogenesis of miscarriages (2, 3) and can influence to trophoblast apoptosis. The aim of research was to investigate study specialty of mRNA expression of TLR1-10 and caspase-3a in endometrium at patients with early miscarriagesBelgorod State Universit

Influence of the microbiological fertilizer Slavol on the formation of early harvest of potatoes in the conditions of the Moscow region

The article presents the results of a study of obtaining early potato production using a microbiological fertilizer in the conditions of the Moscow region. Early potato varieties were used for the study: Udacha, Bryansk delicacy, Red Scarlett, Zhukovsky early, Meteor, Riviera. All varieties of table appointment with high palatability are recommended for cultivation in the Nonchernozem zone of the Russian Federation. The purpose of the research is to study the effect of the microbiological fertilizer Slavol on the growth, development of early potato plants and productivity. The experiment was carried out in 2020-2021. Observations and records in the experiment were carried out according to generally accepted methods when conducting field and laboratory studies on potato crops. Mass seedlings were noted in the variants with the treatment of tubers with the microbiological fertilizer Slavol in the following sequence: variety Zhukovsky, Meteor, Riviera, Udacha, Bryansk delicacy. The maximum total period from germination to harvesting on July 15 was longer in the variant with treatment in the Zhukovsky early variety (56 days), which further affected the increase in yield. The use of the microbiological fertilizer Slavol contributed to an increase in yield for all the studied varieties from 22.2 to 42.8% in relation to the control variant. Thus, in the experiment, the positive effect of microbiological fertilizer Slavol on the growth, development and yield of early potato varieties in the conditions of the Moscow region was established

Strategies and prospects for territorial mobility of environmental graduates with higher education

The article presents the results of a study of the strategy and prospects of territorial mobility of young people who have received higher education in the field of ecology at a regional university. A review of scientific literature and a statistical analysis of the opinions and judgments of environmental students of the last year of study at the bachelor’s program at the Agricultural University confirm the relevance of the research topic. They allow you to look at the prospects for the territorial mobility of environmental graduates, both from the point of view of their own targets, and from the point of view of their importance for the south of Russia and the capital regions of Russia. The study found that the vector of territorial mobility of environmental graduates is aimed at the capital regions of Russia and abroad. The expectations of young people are associated with higher job prospects on better conditions (high-paying and interesting work with real career opportunities) outside the Stavropol Territory and southern Russia

THE USE OF HYALURONIC ACID IN GONARTHROSIS IN REAL CLINICAL PRACTICE

Objectives. To assess the frequency and preferences when assigning intraarticular therapy with hyaluronic acid (HA) in knee оsteoarthritis (ОА) in clinical practice. Material and methods. The analysis of 200 patient records with knee OA treated at the regional center of rheumatology to assess the frequency and spectrum assignment of НА, profile of patients, who were prescribed HA, and its effectiveness. To assess the opinions of rheumatologists on intraarticular therapy with НА we conducted an anonymous questionnaire of 20 rheumatologists of Ekaterinburg. Results. The analysis showed that intraarticular НА therapy was recommended by rheumatologists to 46% of patients with knee ОА, of which the treatment was performed in only 35%. Patients who received treatment were older and more often took NSAIDs and symptomatic slow-acting drugs. Intra-articular НА therapy was effective in 69% of patients. НА with higher molecular weight were more effective, although rheumatologists prefer НА with low molecular weight. Conclusion. In clinical practice, НА is used widely in the treatment of knee ОА, a positive effect from the treatment noted in more than a half of patients

Correction of microbiocenosis of female reproductive tract during the late stage of pregnancy

Pobedi str., 85, Belgorod, Russia, 308024 Bacteriological examination of cervical canal at 34 women in 38—40 weeks of gestation has been made before and after intravaginal usage of Gynoflor (“Medinova”, Switzerland), containing 50 mg of Lactobacillus acidophilius and 0,03 mg of estriol. It is established, that after usage of Gynoflor significant decrease of number of patients with Staphylococcus epidermidis and Peptococcus has been observed. Furthermore, lowering of number of women with other opportunistic bacteria and yeasts ( Staphylococcus aureus , Klebsiella pneumonia , Enterococcus , Enterobacter , Streptococcus , Bacteroides , Candida albicans ) has been appeared. It was accompanied with decrease of colony forming units number among all opportunistic species

НОВЫЙ УЛЬТРАЗВУКОВОЙ КРИТЕРИЙ ОЦЕНКИ РАЗМЕРОВ СЕЛЕЗЕНКИ У ДЕТЕЙ И ОПРЕДЕЛЕНИЕ ДИАПАЗОНА НОРМАТИВНЫХ ЗНАЧЕНИЙ ОРГАНА

The study was aimed at establishing a new ultrasonic criterion of evaluating spleen dimensions in children (area of the maximum axial section) and determining the range of normal spleen dimensions. Patients and methods: We analyzed 838 ultrasonic spleen examinations in 3‑15‑year-old children and determined the area of the maximum axial section by tracing the scan obtained with a medical device. Results: on the basis of ultrasonic examination data analysis, we established a formula, which helps to calculate the spleen section area with the organ’s length and thickness. We performed retrospective analysis of 4,001 standard ultrasonic examinations followed by formula evaluation of the area of maximum axial section. Conclusion: on the basis of the comparative analysis of the measured and calculated areas of the maximum spleen axial section, we established a range of normal values of this parameter taking age and sex into account. Цель исследования: установить новый ультразвуковой критерий оценки размеров селезенки у детей — площадь максимального продольного сечения и определить диапазон его нормативных значений. Пациенты и методы. Проведен анализ 838 ультразвуковых исследований селезенки у детей в возрасте от 3 до 15 лет с определением площади максимального продольного сечения путем трассировки полученного скана на приборе. Результаты. На основании анализа данных УЗИ рассчитана формула, позволяющая вычислить площадь сечения селезенки при наличии длины и толщины органа. Выполнен ретроспективный анализ 4001 стандартного ультразвукового исследования селезенки с последующим расчетом по формуле площади максимального продольного сечения. Заключение. На основании сравнительного анализа измеренных и рассчитанных значений площади максимального продольного сечения селезенки установлен диапазон нормативных показателей этого параметра с учетом возраста и пола