УКРАЇНСЬКА НАРОДНА МЕДИЦИНА

This article contains important and interesting information on traditional medicine, which stands as one of the most important aspects of alternative medicine, more used in everyday life of modern society, difference from conventional medicine, which not everyone knows and does not always know how to use.У статті міститься важлива і цікава інформація про народну медицину, яка виступає одним із важливих аспектів нетрадиційної медицини, більш уживана у повсякденному житті сучасним суспільством, на відміну від традиційної медицини, яку не всі знають і не завжди вміють використати

НЕТРАДИЦІЙНІ МЕТОДИ ЛІКУВАННЯ ОЖИРІННЯ В ДІТЕЙ

The article presents the main peculiarities of the obesity progression in children and alternative methods of its treatment. There are described the rules in detail of the diet therapy in the case of increased body mass, and also methods of the phytotherapy and therapeutic exercises.У статті описано особливості розвитку ожиріння у дітей та нетрадиційні методи його лікування. Детально пояснені правила дієтотерапії при підвищеній масі тіла, а також методики застосування фітотерапії та лікувальної фізкультури

PPAR-γ in the Cardiovascular System

Peroxisome proliferator-activated receptor-γ (PPAR-γ), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular diseases (CVD) such as hypertension, cardiac hypertrophy, congestive heart failure, and atherosclerosis. PPAR-γ agonists, the thiazolidinediones (TZDs), increase insulin sensitivity, lower blood glucose, decrease circulating free fatty acids and triglycerides, lower blood pressure, reduce inflammatory markers, and reduce atherosclerosis in insulin-resistant patients and animal models. Human genetic studies on PPAR-γ have revealed that functional changes in this nuclear receptor are associated with CVD. Recent controversial clinical studies raise the question of deleterious action of PPAR-γ agonists on the cardiovascular system. These complex interactions of metabolic responsive factors and cardiovascular disease promise to be important areas of focus for the future

Direct monitoring pressure overload predicts cardiac hypertrophy in mice

Pressure overload (POL) is a classical model for studying cardiac hypertrophy, but there has been no direct measure of hemodynamics in a conscious ambulatory mouse model of POL. We used abdominal aortic constriction to produce POL and radiotelemetry to measure the blood pressure and heart rate for three weeks. The cardiac size correlated with the systolic pressure in the last week is better than other hemodynamic parameters. Cardiac fibrosis was more correlated to the cardiac size than to the systolic pressure. The expression of the cardiac genes that are typically associated with cardiac hypertrophy was correlated with both cardiac size and systolic pressure. In conclusion, the systolic pressure is the major determinant of cardiac hypertrophy in the murine POL model. In contrast, cardiac fibrosis shows the influence of other factors besides systolic pressure. The combination of the POL model with continuous direct measurements of hemodynamics represents a significant technological advance and will lead to an extended usefulness of POL methodologically.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58150/2/pm7_11_001.pd

Research of component composition and catalitic reactivity of metallurgical industry slag

The article deals with the research of component composition and catalitic reactivity of metallurgical waste products. The slags component composition was investigated by X-ray fluorescence analysis. The slag stuff has been modified with alkali (NaOH) and mineral acids (HNO3, H2SO4, HCI and H3PO4), and their catalytic reactivity in the catalytic decomposition of ethyl alcohol and hydrogen peroxide has been determined for the first time. The revealed catalytic reactivity of the slag staff for the decomposition of ethyl alcohol and hydrogen peroxide indicates the need for a more detailed research and development of an industrial non-ferrous waste treatment technology

Research of component composition and catalitic reactivity of metallurgical industry slag

The article deals with the research of component composition and catalitic reactivity of metallurgical waste products. The slags component composition was investigated by X-ray fluorescence analysis. The slag stuff has been modified with alkali (NaOH) and mineral acids (HNO3, H2SO4, HCI and H3PO4), and their catalytic reactivity in the catalytic decomposition of ethyl alcohol and hydrogen peroxide has been determined for the first time. The revealed catalytic reactivity of the slag staff for the decomposition of ethyl alcohol and hydrogen peroxide indicates the need for a more detailed research and development of an industrial non-ferrous waste treatment technology

Research on zinc concentrate dressing at the zhezkent processing plant to obtain conditioned concentrate

The article investigates dressing of zinc concentrate of Zhezkent processing plant with the purpose of receiving conditioned zinc concentrate and copper product output. The scheme of the zinc concentrate ressing is suggested which includes the following operations: desorption of the initial concentrate by sodium sulfide and activated carbon; preliminary hydraulic classification (washing of thin sludge) complicating the flotation process; comminution of the concentrate in a ball mill up to the size of 96 %, class - 0,044 mm; flotation of copper minerals by reagents: xanthate, Methyl isobutyl ketone blowing agent, and depressors (Na2S, FeSO4, ZnSO4). The proposed dressing scheme provides obtaining conditioned zinc concentrate of grade KC-3 with Zn 47,0 %, and Cu 1,9 %

Bioinformatics analysis of the interaction of miRNAs and piRNAs with human mRNA genes having di- and trinucleotide repeats

The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative and oncological diseases and diabetes have been actively studied. We explored candidate genes with nucleotide repeats to predict associations with miRNAs and piRNAs. The parameters of miRNAs and piRNA binding sites with mRNAs of human genes having nucleotide repeats were determined using the MirTarget program. This program defines the start of the initiation of miRNA and piRNA binding to mRNAs, the localization of miRNA and piRNA binding sites in the 5'-untranslated region (5'UTR), coding sequence (CDS) and 3'-untranslated region (3'UTR); the free energy of binding; and the schemes of nucleotide interactions of miRNAs and piRNAs with mRNAs. The characteristics of miRNAs and piRNA binding sites with mRNAs of 73 human genes were determined. The 5'UTR, 3'UTR and CDS of the mRNAs of genes are involved in the development of neurodegenerative, oncological and diabetes diseases with GU, AC dinucleotide and CCG, CAG, GCC, CGG, CGC trinucleotide repeats. The associations of miRNAs, piRNAs and candidate target genes could be recommended for developing methods for diagnosing diseases, including neurodegenerative diseases, oncological diseases and diabetes