Mesalamine-Induced Myocarditis and Coronary Vasculitis in a Pediatric Ulcerative Colitis Patient: A Case Report

Mesalamine-containing products are often a first-line treatment for ulcerative colitis. Severe adverse reactions to these products, including cardiovascular toxicity, are rarely seen in pediatric patients. We present a case of a 16-year-old boy with ulcerative colitis treated with Asacol, a mesalamine-containing product, who developed sudden onset chest pain after four weeks on therapy. Serial electrocardiograms showed nonspecific ST segment changes, an echocardiogram showed mildly decreased left ventricular systolic function with mild to moderate left ventricular dilation and coronary ectasia, and his troponins were elevated. Following Asacol discontinuation, his chest pain resolved, troponins were trending towards normal, left ventricular systolic function normalized, and coronary ectasia improved within 24 hours suggesting an Asacol-associated severe drug reaction. Mesalamine-induced cardiovascular toxicity, although rare, may represent a life-threatening disorder. Therefore, every patient presenting with acute chest pain should receive a workup to rule out this rare drug-induced disorder

Alternativas de formación educativa en San Basilio de Palenque para los practicantes de la medicina tradicional

El presente proyecto busca darle reconocimiento a la población de palenque en sus prácticas de salud ancestrales, y al mismo tiempo trata de dar una solución a esta situación sanitaria y legal que aqueja a esta población, con el fin de proporcionar los recursos gubernamentales necesarios para el mejoramiento del ámbito de la medicina de este territorio.Nos proponemos de manera práctica e inmediata brindarles más participación en el ámbito de la medicina científica a los “curanderos” como son denominados en palenque de tal forma que articulando estos dos tipos de medicina, puedan resultar muchos beneficios tanto a la sociedad palenquera como a las demás civilizaciones mediante la medicina moderna o científica

KELT-11b: A Highly Inflated Sub-Saturn Exoplanet Transiting the V=8 Subgiant HD 93396

We report the discovery of a transiting exoplanet, KELT-11b, orbiting the bright ($V=8.0$) subgiant HD 93396. A global analysis of the system shows that the host star is an evolved subgiant star with $T_{\rm eff} = 5370\pm51$ K, $M_{*} = 1.438_{-0.052}^{+0.061} M_{\odot}$, $R_{*} = 2.72_{-0.17}^{+0.21} R_{\odot}$, log $g_*= 3.727_{-0.046}^{+0.040}$, and [Fe/H]$= 0.180\pm0.075$. The planet is a low-mass gas giant in a $P = 4.736529\pm0.00006$ day orbit, with $M_{P} = 0.195\pm0.018 M_J$, $R_{P}= 1.37_{-0.12}^{+0.15} R_J$, $\rho_{P} = 0.093_{-0.024}^{+0.028}$ g cm$^{-3}$, surface gravity log ${g_{P}} = 2.407_{-0.086}^{+0.080}$, and equilibrium temperature $T_{eq} = 1712_{-46}^{+51}$ K. KELT-11 is the brightest known transiting exoplanet host in the southern hemisphere by more than a magnitude, and is the 6th brightest transit host to date. The planet is one of the most inflated planets known, with an exceptionally large atmospheric scale height (2763 km), and an associated size of the expected atmospheric transmission signal of 5.6%. These attributes make the KELT-11 system a valuable target for follow-up and atmospheric characterization, and it promises to become one of the benchmark systems for the study of inflated exoplanets.Comment: 15 pages, Submitted to AAS Journal

KELT-14b and KELT-15b: an independent discovery of WASP-122b and a new hot Jupiter

We report the discovery of KELT-14b and KELT-15b, two hot Jupiters from the KELT-South survey. KELT-14b, an independent discovery of the recently announced WASP-122b, is an inflated Jupiter mass planet that orbits a similar to 5.0(-0.7)(+0.3) (0)7 Gyr, V= 11.0, G2 star that is near the main sequence turnoff. The host star, KELT-14 (TYC 7638-981-1), has an inferred mass M* = 1.18(-0.7)(+0.3) M-circle dot and radius R* = 1.37 +/- -0.08 R-circle dot), and has T-eff = 58021 K, log g* = 4.23(-0.7)(+0.3) SI and [Fe/H] = 0.33 +/- -0.09. The planet orbits with a period of 1.7100588 +/- 0.0000025 days (T-0 = 2457091.02863 +/- 0.00047) and has a radius R-p = 1.521 Ri and mass Mp = 1.196 +/- 0.072 MI, and the eccentricity is consistent with zero. KELT-15b is another inflated Jupiter mass planet that orbits a similar to 4.6(-0.4)(+0.5) Gyr, V = 11.2, GO star (TYC 8146-86-1) that is near the 'blue hook' stage of evolution prior to the Hertzsprung gap, and has an inferred mass M* = 1.181(0.050)(+0.05) M-circle dot and radius R* = 1.481 R-circle dot, and T-eff = 6003-% K, log g* = 4.17(-0.04)(+0.02) and [Fe/H] = 0.05 +/- 0.03. The planet orbits on a period of 3.329441 +/- 0.000016 days (T0 = 2457029.1663 0.0073) and has a radius Rp = 1.443 (o)Ols7 Ri and mass M-p = 0.91 531 MI and an eccentricity consistent with zero. KELT-14b has the second largest expected emission signal in the K-band for known transiting planets brighter than K < 10.5. Both KELT-14b and KELT-15b are predicted to have large enough emission signals that their secondary eclipses should be detectable using ground-based observatories

TIC 168789840: A Sextuply-Eclipsing Sextuple Star System

We report the discovery of a sextuply-eclipsing sextuple star system from TESS data, TIC 168789840, also known as TYC 7037-89-1, the first known sextuple system consisting of three eclipsing binaries. The target was observed in Sectors 4 and 5 during Cycle 1, with lightcurves extracted from TESS Full Frame Image data. It was also previously observed by the WASP survey and ASAS-SN. The system consists of three gravitationally-bound eclipsing binaries in a hierarchical structure of an inner quadruple system with an outer binary subsystem. Follow-up observations from several different observatories were conducted as a means of determining additional parameters. The system was resolved by speckle interferometry with a 0."42 separation between the inner quadruple and outer binary, inferring an estimated outer period of ~2 kyr. It was determined that the fainter of the two resolved components is an 8.217 day eclipsing binary, which orbits the inner quadruple that contains two eclipsing binaries with periods of 1.570 days and 1.306 days. MCMC analysis of the stellar parameters has shown that the three binaries of TIC 168789840 are "triplets", as each binary is quite similar to the others in terms of mass, radius, and Teff. As a consequence of its rare composition, structure, and orientation, this object can provide important new insight into the formation, dynamics, and evolution of multiple star systems. Future observations could reveal if the intermediate and outer orbital planes are all aligned with the planes of the three inner eclipsing binaries

The AUXIN BINDING PROTEIN 1 Is Required for Differential Auxin Responses Mediating Root Growth

Background In plants, the phytohormone auxin is a crucial regulator sustaining growth and development. At the cellular level, auxin is interpreted differentially in a tissue- and dose-dependent manner. Mechanisms of auxin signalling are partially unknown and the contribution of the AUXIN BINDING PROTEIN 1 (ABP1) as an auxin receptor is still a matter of debate. Methodology/Principal Findings Here we took advantage of the present knowledge of the root biological system to demonstrate that ABP1 is required for auxin response. The use of conditional ABP1 defective plants reveals that the protein is essential for maintenance of the root meristem and acts at least on the D-type CYCLIN/RETINOBLASTOMA pathway to control entry into the cell cycle. ABP1 affects PLETHORA gradients and confers auxin sensitivity to root cells thus defining the competence of the cells to be maintained within the meristem or to elongate. ABP1 is also implicated in the regulation of gene expression in response to auxin. Conclusions/Significance Our data support that ABP1 is a key regulator for root growth and is required for auxin-mediated responses. Differential effects of ABP1 on various auxin responses support a model in which ABP1 is the major regulator for auxin action on the cell cycle and regulates auxin-mediated gene expression and cell elongation in addition to the already well known TIR1-mediated ubiquitination pathway