Using intelligent optimization methods to improve the group method of data handling in time series prediction

In this paper we show how the performance of the basic algorithm of the Group Method of Data Handling (GMDH) can be improved using Genetic Algorithms (GA) and Particle Swarm Optimization (PSO). The new improved GMDH is then used to predict currency exchange rates: the US Dollar to the Euros. The performance of the hybrid GMDHs are compared with that of the conventional GMDH. Two performance measures, the root mean squared error and the mean absolute percentage errors show that the hybrid GMDH algorithm gives more accurate predictions than the conventional GMDH algorithm

Ergatic dynamic control systems

Synthesis and analysis of systems containing a man in their control circuits are considered. The concepts of ergonomics and ergatic systems are defined, and tasks and problems of ergonomics are outlined. The synthesis of the structure of an astronautic ergatic organism is presented, as well as the synthesis of nonstationary ergatic systems. Problems of selecting the criteria for complex systems are considered, and the results are presented from a study of ergatic control systems with any degree of human participation

Alternative fast quantum logic gates using nonadiabatic Landau-Zener-St\"{u}ckelberg-Majorana transitions

A conventional realization of quantum logic gates and control is based on resonant Rabi oscillations of the occupation probability of the system. This approach has certain limitations and complications, like counter-rotating terms. We study an alternative paradigm for implementing quantum logic gates based on Landau-Zener-St\"{u}ckelberg-Majorana (LZSM) interferometry with non-resonant driving and the alternation of adiabatic evolution and non-adiabatic transitions. Compared to Rabi oscillations, the main differences are a non-resonant driving frequency and a small number of periods in the external driving. We explore the dynamics of a multilevel quantum system under LZSM drives and optimize the parameters for increasing single- and two-qubit gates speed. We define the parameters of the external driving required for implementing some specific gates using the adiabatic-impulse model. The LZSM approach can be applied to a large variety of multi-level quantum systems and external driving, providing a method for implementing quantum logic gates on them.Comment: 15 pages, 12 figure

Application of innovative business models in innovation management at enterprises in risk conditions

Метою дослідження є розробка методичних рекомендацій щодо організації процесу впровадження інновацій на підприємстві з урахуванням взаємодії окремих підрозділів підприємства і ризиків, які виникають в процесі втілення інновацій. Запропоновано використання інноваційних бізнес-моделей для управління інноваціями. Алгоритм управління впровадженням інновацій на підприємстві розроблений з урахуванням ризиків. Наведено порівняння різних систем планування впровадження інновацій на підприємстві. Розроблено заходи щодо організації управління процесом впровадження інновацій на підприємстві. Узагальнений перелік задач управління інноваціями з урахуванням ризиків, які повинні мінімізуватися в процесі планування та впровадження інновацій. Практичне значення дослідження полягає у розробці методології формування управління інноваційною діяльністю на промислових підприємствах з використанням інноваційних бізнес-моделей з урахуванням ризиків.Introduction. The possibility of using innovative business models in the management of innovation implementation at an industrial enterprise is evaluated. The use of innovative business models for innovation management is offered. Purpose. The purpose of the study is to develop guidelines for the organization of innovation process at the enterprise, taking into account the interaction of individual units of the enterprise and the risks that arise in the implementation of innovations. Results. The management algorithm of innovations introduction at the enterprise is developed taking into account risks. The comparison of various systems of planning of introduction of innovations at the enterprise is resulted. Measures are developed for the management organization process of innovations introduction at the enterprise. The components of the management system for the innovations implementation at industrial enterprise have been developed. There was taken into account that in management theory have several approaches to the allocation of general management functions choosing an approach to their classification. The classification with the following components of management functions is chosen as the basic one: organization, planning, distribution, control, analysis. Tasks of innovations introduction management are systematized on the general management functions. The production structures and employees job responsibilities of a number of industrial enterprises were analyzed, it allowed to determine the existence of problems with these tasks compliance of innovation management at the enterprise. Conclusions. The list of innovation management tasks is generalized, they have to be performed in the process of planning and implementation of innovations. The practical significance of the study is to develop a methodology for the innovative activities management formation at industrial enterprises using innovative business models, taking into account the risks

Mirabegron: pharmacoeconomic aspects of the use of the drug for the treatment of overactive bladder syndrome

According to the International Continence Society (ICS), symptoms of overactive bladder (OAB) are present in 17 % of the adult population of Europe. The prevalence of overactive bladder in Russia is unknown but is considered comparable to that in European countries. According to Russian guidelines, patients with OAB could be treated with antimuscarinics or beta 3-agonists. The results of a meta-analysis by Wang J et al. (2018) showed comparable efficacy and safety of mirabegron and solifenacin. At the same time, according to Chapple CR et al. (2017) and Yeowell G et al. (2018) the use of mirabegron is associated with greater adherence to therapy and longer average drug use before the need to change therapy compared to antimuscarinics. From an economic point of view, greater adherence to drug therapy is associated with lower costs per patient with OAB per year and mirabegron have demonstrated to be cost-eff ective in comparison to solifenacin. The results of the analysis of the structure and volume of providing various types of medical care to patients with OAB in the Moscow region demonstrate the need to expand approaches to providing drug care to this group of patients. Currently, the majority of costs related to patients with OAB are associated with surgical treatment, which indicates the opportunity to expand the possibilities of drug therapy, including within the framework of preferential drug provision

Assessment of the availability of remote recording to the doctor in polyclinics of Yekaterinburg

The article describes the results of assessing the availability of remote appointments to the doctor in the clinic at the place of residence using the service "Appointment to the doctor online" through the official portal of the city of Yekaterinburg.В статье описываются результаты оценки доступности дистанционной записи на прием к врачу в поликлинику по месту жительства с помощью интернет сервиса «Запись на прием к врачу онлайн» через официальный портал города Екатеринбурга

Impedance-Matching Hearing in Paleozoic Reptiles: Evidence of Advanced Sensory Perception at an Early Stage of Amniote Evolution

BACKGROUND: Insights into the onset of evolutionary novelties are key to the understanding of amniote origins and diversification. The possession of an impedance-matching tympanic middle ear is characteristic of all terrestrial vertebrates with a sophisticated hearing sense and an adaptively important feature of many modern terrestrial vertebrates. Whereas tympanic ears seem to have evolved multiple times within tetrapods, especially among crown-group members such as frogs, mammals, squamates, turtles, crocodiles, and birds, the presence of true tympanic ears has never been recorded in a Paleozoic amniote, suggesting they evolved fairly recently in amniote history. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we performed a morphological examination and a phylogenetic analysis of poorly known parareptiles from the Middle Permian of the Mezen River Basin in Russia. We recovered a well-supported clade that is characterized by a unique cheek morphology indicative of a tympanum stretching across large parts of the temporal region to an extent not seen in other amniotes, fossil or extant, and a braincase specialized in showing modifications clearly related to an increase in auditory function, unlike the braincase of any other Paleozoic tetrapod. In addition, we estimated the ratio of the tympanum area relative to the stapedial footplate for the basalmost taxon of the clade, which, at 23:1, is in close correspondence to that of modern amniotes capable of efficient impedance-matching hearing. CONCLUSIONS/SIGNIFICANCE: Using modern amniotes as analogues, the possession of an impedance-matching middle ear in these parareptiles suggests unique ecological adaptations potentially related to living in dim-light environments. More importantly, our results demonstrate that already at an early stage of amniote diversification, and prior to the Permo-Triassic extinction event, the complexity of terrestrial vertebrate ecosystems had reached a level that proved advanced sensory perception to be of notable adaptive significance