UbiREMOTE: framework for remotely controlling networked appliances through interaction with 3D virtual space

MMSys '10 : first annual ACM SIGMM conference on Multimedia systems , Feb 22-23, 2010 , Phoenix, Arizona, USAIn this paper, we propose a framework named ``UbiREMOTE'' for controlling information appliances connected to a home network with a unified and intuitive user interface from a remote place.The UbiREMOTE framework provides users with a way to control appliances in a home through a virtual space drawn on a mobile terminal screen which reflects the latest conditions of the real appliances and the rooms in the home. With UbiREMOTE, a user controls appliances by (1) moving to the front of an appliance, (2) choosing the appliance to control and (3) pushing buttons on the virtual remote controller which imitates the real remote controller for the appliance or the real console.In this paper, we propose a method to improve the drawing speed of 3D virtual space on mobile terminals and a method for automatically reflecting condition changes of the real space in the virtual space.We implemented the methods and evaluated the performance. The results showed that the proposed methods can be practically used on small mobile terminals

Endoplasmic Reticulum Associated Degradation of Spinocerebellar Ataxia-Related CD10 Cysteine Mutant

Spinocerebellar ataxia (SCA) is one of the most severe neurodegenerative diseases and is often associated with misfolded protein aggregates derived from the genetic mutation of related genes. Recently, mutations in CD10 such as C143Y have been identified as SCA type 43. CD10, also known as neprilysin or neuroendopeptidase, digests functional neuropeptides, such as amyloid beta, in the extracellular region. In this study, we explored the cellular behavior of CD10 C143Y to gain an insight into the functional relationship of the mutation and SCA pathology. We found that wild-type CD10 is expressed on the plasma membrane and exhibits endopeptidase activity in a cultured cell line. CD10 C143Y, however, forms a disulfide bond-mediated oligomer that does not appear by the wild-type CD10. Furthermore, the CD10 C143Y mutant was retained in the endoplasmic reticulum (ER) by the molecular chaperone BiP and was degraded through the ER-associated degradation (ERAD) process, in which representative ERAD factors including EDEM1, SEL1L, and Hrd1 participate in the degradation. Suppression of CD10 C143Y ERAD recovers intracellular transport but not enzymatic activity. Our results indicate that the C143Y mutation in CD10 negatively a ects protein maturation and results in ER retention and following ERAD. These findings provide beneficial insight into SCA type 43 pathology

Stable sustainment of plasmas with electron internal transport barrier by ECH in the LHD

The long pulse experiments in the Large Helical Device has made progress in sustainment of improved confinement states. It was found that steady-state sustainment of the plasmas with improved confinement at the core region, that is, electron internal transport barrier (e-ITB), was achieved with no significant difficulty. Sustainment of a plasma having e-ITB with the line average electron density ne_ave of 1.1 × 1019 m−3 and the central electron temperature Te0 of ∼3.5 keV for longer than 5 min only with 340 kW ECH power was successfully demonstrated

Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease

AimsLimited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH.MethodsThis retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death.ResultsThe 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45–13.73; P = .009).ConclusionsThe IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered

Audiovisual integration in Mongolian Gerbil Evaluated with Sensory Evoked Potentials

ヒトは複数の感覚入力を統合することによって外界を知覚している。視聴覚統合はラットやマウスのような標準的な実験動物であるげっ歯類において研究されている。しかしながらヒトとは異なり、両種とも夜行性である。彼らは視力が悪く、低周波（<5 kHz）に対する聴覚感度はヒトの聴覚感度に比べ著しく悪い。したがって、彼らは視聴覚統合を研究するには不適切な動物モデルである。スナネズミは比較的良好な視力を有しており、その低周波の感度はヒトに似ている。したがって、本研究において、私たちはスナネズミの視覚野周辺での視聴覚統合に関連のある領域を調べた。私たちは視覚刺激のみ、聴覚刺激のみ、視聴覚同時刺激によって生じる感覚誘発電位を計測した。計測部位はそれぞれ1 mm間隔離して計測した。それぞれの計測部位において、視聴覚同時刺激の誘発電位波形と聴覚、視覚単独での誘発電位を足し合わせた波形の類似度を比較した。その結果、計測部位によって類似性が異っており、二次視覚野（V2L）周辺（ラムダから外側に4 mm、前方に2 mm）で最も類似度が低かった。これらの結果から、V2Lはスナネズミにおいて視聴覚統合に関係があり、スナネズミは視聴覚統合の神経基盤を研究するのに適したモデル動物であることを示唆している。Humans perceive the world by integrating multiple sensory inputs. Audiovisual integration has been studied in standard laboratory rodents, such as rats and mice. However, unlike humans, both species are nocturnal. They have poor visual acuity and their auditory sensitivity to low frequencies (<5 kHz) is significantly worse than that of humans (by at least 20 dB). Therefore, they are unsuitable animal models in which to study audiovisual integration. The Mongolian gerbil, [Meriones unguiculatus], has relatively good eyesight and its low-frequency sensitivity is similar to that of humans. Therefore, in this study, we investigated the brain regions related to audiovisual integration around the visual cortex in the Mongolian gerbil. We recorded the sensory evoked potentials (EPs) generated by a visual stimulus alone, an auditory stimulus alone, and synchronized audiovisual stimuli. Each recording site was separated by 1 mm pitch. The similarity of the EP waveforms was evaluated between the audiovisual EP and the sum of the auditory and visual EPs at each recording site. The results showed that the similarity varied depending on the site, and was the lowest around the lateral secondary visual cortex (4 mm lateral and 2 mm anterior to lambda). These results suggest that V2L is associated with audiovisual integration in the gerbil, and that the species is a suitable animal model in which to study the neural basis of audiovisual integration.内容記述(英語)中の[Meriones unguiculatus]は斜体文

UbiREMOTE: framework for remotely controlling networked appliances through interaction with 3D virtual space

In this paper, we propose a framework named ``UbiREMOTE'' for controlling information appliances connected to a home network with a unified and intuitive user interface from a remote place.The UbiREMOTE framework provides users with a way to control appliances in a home through a virtual space drawn on a mobile terminal screen which reflects the latest conditions of the real appliances and the rooms in the home. With UbiREMOTE, a user controls appliances by (1) moving to the front of an appliance, (2) choosing the appliance to control and (3) pushing buttons on the virtual remote controller which imitates the real remote controller for the appliance or the real console.In this paper, we propose a method to improve the drawing speed of 3D virtual space on mobile terminals and a method for automatically reflecting condition changes of the real space in the virtual space.We implemented the methods and evaluated the performance. The results showed that the proposed methods can be practically used on small mobile terminals