20 research outputs found

    Fully guided electrically-controlled exciton polaritons

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    We demonstrate two types of waveguide structures which optically confine exciton- polaritons in two dimensions and act as polaritonic channels. We show a strong optical confinement in an etched rectangular waveguide, that significantly increases the propa- gation distance of the polaritons and allow to direct them in curved trajectories. Also, we show low-loss optical guiding over a record-high of hundreds of microns which is com- bined seamlessly with electrical control of the polaritons, in a strip waveguide formed by electrically conductive and optically transparent strips deposited on top of a planar waveguide. Both structures are scalable and easy to fabricate and offer new possibilities for designing complex polaritonic devices.Comment: 12 pages 3 Figuer

    Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

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    Abstract Cancer somatic mutations are the product of multiple mutational and repair processes, some of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes can affect this association. Systematic analysis of the mutational landscape of 2787 tumors from 32 tumor types revealed that approximately one third of the tumor samples show weak association between replication timing and mutation rate. Further analyses revealed that those samples have unique mutational signatures and are enriched with mutations in genes involved in DNA replication, DNA repair and chromatin structure. Surprisingly, analysis of differentially expressed genes between weak and strong RT-MR association groups revealed that tumors with weak association are enriched with genes associated with cell–cell communication and the immune system, suggesting a non-autonomous response to DNA damage
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