Abundant dust found in intergalactic space

Galactic dust constitutes approximately half of the elements more massive than helium produced in stellar nucleosynthesis. Notwithstanding the formation of dust grains in the dense, cool atmospheres of late-type stars, there still remain huge uncertainties concerning the origin and fate of galactic stardust. In this paper, we identify the intergalactic medium (i.e. the region between gravitationally-bound galaxies) as a major sink for galactic dust. We discover a systematic shift in the colour of background galaxies viewed through the intergalactic medium of the nearby M81 group. This reddening coincides with atomic, neutral gas previously detected between the group members. The dust-to-HI mass ratio is high (1/20) compared to that of the solar neighborhood (1/120) suggesting that the dust originates from the centre of one or more of the galaxies in the group. Indeed, M82, which is known to be ejecting dust and gas in a starburst-driven superwind, is cited as the probable main source.Comment: 5 pages, 3 figures, 1 table. ApJ Letters in pres

The Reddest DR3 SDSS/XMM Quasars

We have cross-correlated the SDSS DR3 Schneider et al. (2005) quasar catalog with the XMM-Newton archive. Color and redshift selections (g - r > 0.5 and 0.9 z < 2.1) result in a sample of 17 red, moderate redshift quasars. The redshift selection minimizes possible contamination due to host galaxy emission and Lyalpha forest absorption. Both optical and X-ray information are required to distinguish between the two likely remaining causes of the red colors: 1) dust-reddening and 2) an intrinsically red continuum. We find that 7 of 17 quasars can be classified as probable `intrinsically red' objects. These 7 quasars have unusually broad MgII emission lines (=10,500 km s^{-1}), moderately flat, but unabsorbed X-ray spectra =1.66+/-0.08), and low accretion rates (mdot/mdot_{Edd}} ~ 0.01). We suggest low accretion rates as a possible physical explanation for quasars with intrinsically red optical continua. We find that 8 of 17 quasars can be classified as dust-reddened. Three of these have upper-limits on the absorption column from X-ray spectral fits of N_H = 3-13 x 10^{22} cm^2, while the other five quasars must be absorbed by at least N_H = 10^{23} cm^2 in order to be consistent with a comparably selected alpha_{ox}-l_{uv} distribution. Two objects in the sample are unclassified.Comment: 20 pages, 12 figures, Accepted for publication in Ap

Metallicities of 0.3<z<1.0 Galaxies in the GOODS-North Field

We measure nebular oxygen abundances for 204 emission-line galaxies with redshifts 0.3<z<1.0 in the Great Observatories Origins Deep Survey North (GOODS-N) field using spectra from the Team Keck Redshift Survey (TKRS). We also provide an updated analytic prescription for estimating oxygen abundances using the traditional strong emission line ratio, R_{23}, based on the photoionization models of Kewley & Dopita (2003). We include an analytic formula for very crude metallicity estimates using the [NII]6584/Halpha ratio. Oxygen abundances for GOODS-N galaxies range from 8.2< 12+log(O/H)< 9.1 corresponding to metallicities between 0.3 and 2.5 times the solar value. This sample of galaxies exhibits a correlation between rest-frame blue luminosity and gas-phase metallicity (i.e., an L-Z relation), consistent with L-Z correlations of previously-studied intermediate-redshift samples. The zero point of the L-Z relation evolves with redshift in the sense that galaxies of a given luminosity become more metal poor at higher redshift. Galaxies in luminosity bins -18.5<M_B<-21.5 exhibit a decrease in average oxygen abundance by 0.14\pm0.05 dex from z=0 to z=1. This rate of metal enrichment means that 28\pm0.07% of metals in local galaxies have been synthesized since z=1, in reasonable agreement with the predictions based on published star formation rate densities which show that ~38% of stars in the universe have formed during the same interval. (Abridged)Comment: AASTeX, 49 pages, 16 figures, accepted for publication in The Astrophysical Journa

Robotic Two-Wheeled Vehicle

A robotic two-wheeled vehicle comprising a connection body interposed between the two wheels are described. A drum can be coaxially located in a central region of the connection body and can support a hollow arm projecting radially from the drum. A tether can be inserted in the arm and connected to a second drum. Instruments and sensors can be accommodated in a case housed inside each wheel

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors.

BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of various membrane transporters. Resistance to chemotherapy may arise due to promoter methylation/downregulation of expression of transporters required for drug uptake, and decitabine can reverse resistance in vitro. The endocytosis regulator RhoA, the folate carriers FOLR1 and RFC1, and the glucose transporter GLUT4 were assessed.ResultsPre-decitabine RhoA was higher in patients who had received their last therapy &gt;3&nbsp;months previously than in patients with more recent prior therapy (P = 0.02), and varied inversely with global DNA methylation as assessed by LINE1 methylation (r = -0.58, P = 0.006). Tumor RhoA scores increased with decitabine (P = 0.03), and RFC1 also increased in patients with pre-decitabine scores ≤150 (P = 0.004). Change in LINE1 methylation with decitabine did not correlate significantly with change in IHC scores for any transporter assessed. We also assessed methylation of the RFC1 gene (alias SLC19A1). SLC19A1 methylation correlated with tumor LINE1 methylation (r = 0.45, P = 0.02). There was a small (statistically insignificant) decrease in SLC19A1 methylation with decitabine, and there was a trend towards change in SLC19A1 methylation with decitabine correlating with change in LINE1 methylation (r = 0.47, P &lt;0.15). While SLC19A1 methylation did not correlate with RFC1 scores, there was a trend towards an inverse correlation between change in SLC19A1 methylation and change in RFC1 expression (r = -0.45, P = 0.19).ConclusionsIn conclusion, after decitabine administration, there was increased expression of some (but not other) transporters that may play a role in chemotherapy uptake. Larger patient numbers will be needed to define the extent to which this increased expression is associated with changes in DNA methylation