785 research outputs found
Novel continuum modeling of crystal surface evolution
We propose a novel approach to continuum modeling of the dynamics of crystal
surfaces. Our model follows the evolution of an ensemble of step
configurations, which are consistent with the macroscopic surface profile.
Contrary to the usual approach where the continuum limit is achieved when
typical surface features consist of many steps, our continuum limit is
approached when the number of step configurations of the ensemble is very
large. The model can handle singular surface structures such as corners and
facets. It has a clear computational advantage over discrete models.Comment: 4 pages, 3 postscript figure
Decay of one dimensional surface modulations
The relaxation process of one dimensional surface modulations is re-examined.
Surface evolution is described in terms of a standard step flow model.
Numerical evidence that the surface slope, D(x,t), obeys the scaling ansatz
D(x,t)=alpha(t)F(x) is provided. We use the scaling ansatz to transform the
discrete step model into a continuum model for surface dynamics. The model
consists of differential equations for the functions alpha(t) and F(x). The
solutions of these equations agree with simulation results of the discrete step
model. We identify two types of possible scaling solutions. Solutions of the
first type have facets at the extremum points, while in solutions of the second
type the facets are replaced by cusps. Interactions between steps of opposite
signs determine whether a system is of the first or second type. Finally, we
relate our model to an actual experiment and find good agreement between a
measured AFM snapshot and a solution of our continuum model.Comment: 18 pages, 6 figures in 9 eps file
Autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA) - Animal models as a proof of concept
ASIA syndrome, 'Autoimmune (Auto-inflammatory) Syndromes Induced by Adjuvants' includes at least four conditions which share a similar complex of signs and symptoms and have been defined by hyperactive immune responses: siliconosis, macrophagic myofasciitis syndrome, Gulf war syndrome and post-vaccination phenomena. Exposure to adjuvants has been documented in these four medical conditions, suggesting that the common denominator to these syndromes is a trigger entailing adjuvant activity. An important role of animal models in proving the ASIA concept has been established. Experimentally animal models of autoimmune diseases induced by adjuvants are currently widely used to understand the mechanisms and etiology and pathogenesis of these diseases and might thus promote the development of new diagnostic, predictive and therapeutic methods. In the current review we wish to unveil the variety of ASIA animal models associated with systemic and organ specific autoimmune diseases induced by adjuvants. We included in this review animal models for rheumatoid arthritis-like disease, for systemic lupus erythematosus-like disease, autoimmune thyroid disease-like disease, antiphospholipid syndrome, myocarditis and others. All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants. © 2013 Bentham Science Publishers
The profile of a decaying crystalline cone
The decay of a crystalline cone below the roughening transition is studied.
We consider local mass transport through surface diffusion, focusing on the two
cases of diffusion limited and attachment-detachment limited step kinetics. In
both cases, we describe the decay kinetics in terms of step flow models.
Numerical simulations of the models indicate that in the attachment-detachment
limited case the system undergoes a step bunching instability if the repulsive
interactions between steps are weak. Such an instability does not occur in the
diffusion limited case. In stable cases the height profile, h(r,t), is flat at
radii r<R(t)\sim t^{1/4}. Outside this flat region the height profile obeys the
scaling scenario \partial h/\partial r = {\cal F}(r t^{-1/4}). A scaling ansatz
for the time-dependent profile of the cone yields analytical values for the
scaling exponents and a differential equation for the scaling function. In the
long time limit this equation provides an exact description of the discrete
step dynamics. It admits a family of solutions and the mechanism responsible
for the selection of a unique scaling function is discussed in detail. Finally
we generalize the model and consider permeable steps by allowing direct adatom
hops between neighboring terraces. We argue that step permeability does not
change the scaling behavior of the system, and its only effect is a
renormalization of some of the parameters.Comment: 25 pages, 18 postscript figure
Non-invertible transformations and spatiotemporal randomness
We generalize the exact solution to the Bernoulli shift map. Under certain
conditions, the generalized functions can produce unpredictable dynamics. We
use the properties of the generalized functions to show that certain dynamical
systems can generate random dynamics. For instance, the chaotic Chua's circuit
coupled to a circuit with a non-invertible I-V characteristic can generate
unpredictable dynamics. In general, a nonperiodic time-series with truncated
exponential behavior can be converted into unpredictable dynamics using
non-invertible transformations. Using a new theoretical framework for chaos and
randomness, we investigate some classes of coupled map lattices. We show that,
in some cases, these systems can produce completely unpredictable dynamics. In
a similar fashion, we explain why some wellknown spatiotemporal systems have
been found to produce very complex dynamics in numerical simulations. We
discuss real physical systems that can generate random dynamics.Comment: Accepted in International Journal of Bifurcation and Chao
The effect of weaning diet type on grey mullet (Mugil cephalus) juvenile performance during the trophic shift from carnivory to omnivory
In captive grey mullet (Mugil cephalus) juveniles, the weaning stage overlaps the period where there are changes in the ontogeny of digestive enzymes as the fry transit from carnivory to omnivory. The aim of this study was to evaluate growth, survival, weight distribution and the activity of pancreatic and brush border digestive enzymes when fry are fed a carnivorous, herbivorous or omnivorous weaning diet.
Fifteen 17-L aquaria in a flow through system with 40‰, UV treated, temperature (24.5 ± 0.5 °C) controlled seawater were stocked with eighty-five 23 dph grey mullet larvae per aquarium. This allowed the testing of three weaning dietary treatments, differing in their protein and carbohydrate content, in 5 replicate aquaria per treatment from 24 to 53 dph. Diet 1 was the dried macroalgal species Ulva lactuca and was designated as a low protein: high carbohydrate herbivorous diet. Diet 2 was a commercial microencapsulated starter feed designated as a high protein: low carbohydrate carnivorous diet. Diet 3 was a 1:1 ww mixture of diets 1 and diet 2 representing an omnivorous feeding regime.
The average final weight of the omnivorous feeding fish was significantly (P .05). The activity levels of brush border alkaline phosphatase and intracellular leucine alanine peptidase were similar in grey mullet fry fed the carnivorous and omnivorous diets, but were higher than those in fish fed the herbivorous diet (P < .05). The intestinal maturation index exhibited the highest and lowest values in mullet fry fed the carnivorous and herbivorous diets, respectively, whereas those from the omnivorous group showed intermediate values (P = .03). This study broadly suggests that aquaculture feeds for juvenile grey mullet should be designed for omnivorous feeding habits.info:eu-repo/semantics/acceptedVersio
Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease
Background: Family studies support a genetic predisposition to inflammatory bowel diseases (IBD), but known genetic variants only partially explain the disease heritability. Families with multiple affected individuals potentially harbour rare and high-impact causal variants. Long regions of homozygosity due to recent inbreeding may increase the risk of individuals bearing homozygous loss-of-function variants. This study aimed to identify rare and homozygous genetic variants contributing to IBD. Methods: Four families with known consanguinity and multiple cases of IBD were recruited. In a family-specific analysis, we utilised homozygosity mapping complemented by whole-exome sequencing. Results: We detected a single region of homozygosity shared by Crohn's disease cases from a family of Druze ancestry, spanning 2.6 Mb containing the NOD2 gene. Whole-exome sequencing did not identify any potentially damaging variants within the region, suggesting that non-coding variation may be involved. In addition, affected individuals in the families harboured several rare and potentially damaging homozygous variants in genes with a role in autophagy and innate immunity including LRRK1, WHAMM, DENND3, and C5. Conclusion: This study examined the potential contribution of rare, high-impact homozygous variants in consanguineous families with IBD. While the analysis was not designed to achieve statistical significance, our findings highlight genes or loci that warrant further research. Non-coding variants affecting NOD2 may be of importance in Druze patients with Crohn's disease
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